Advancements in clinical approaches, analytical methods, and smart sampling for LC–MS‐based protein determination from dried matrix spots

Determination of proteins from dried matrix spots using MS is an expanding research area. Mainly, the collected dried matrix sample is whole blood from a finger or heal prick, resulting in dried blood spots. However as other matrices such as plasma, serum, urine, and tear fluid also can be collected...

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Published inJournal of separation science Vol. 47; no. 9-10; pp. e2400061 - n/a
Main Authors Reubsaet, Léon, Halvorsen, Trine Grønhaug
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.05.2024
Subjects
Affinity
Analytical chemistry
Antibodies
bioactive proteins
Biological activity
Biomedical research
Blood
blood serum
Dried Blood Spot Testing
dried blood spots
Humans
LC–MS determination
Liquid Chromatography-Mass Spectrometry
Mass spectrometry
Proteins
Proteins - analysis
proteolysis
Proteomics
Proteomics - methods
Sampling
separation
smart sampling
Specimen Handling
urine
LC–MS determination
bioactive proteins
smart sampling
dried blood spots
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Abstract Determination of proteins from dried matrix spots using MS is an expanding research area. Mainly, the collected dried matrix sample is whole blood from a finger or heal prick, resulting in dried blood spots. However as other matrices such as plasma, serum, urine, and tear fluid also can be collected in this way, the term dried matrix spot is used as an overarching term. In this review, the focus is on advancements in the field made from 2017 up to 2023. In the first part reviews concerning the subject are discussed. After this, advancements made for clinical purposes are highlighted. Both targeted protein analyses, with and without the use of affinity extractions, as well as untargeted, global proteomic approaches are discussed. In the last part, both methodological advancements are being reviewed as well as the possibility to integrate sample preparation steps during the sample handling. The focus, of this so‐called smart sampling, is on the incorporation of cell separation, proteolysis, and antibody‐based affinity capture.
AbstractList Determination of proteins from dried matrix spots using MS is an expanding research area. Mainly, the collected dried matrix sample is whole blood from a finger or heal prick, resulting in dried blood spots. However as other matrices such as plasma, serum, urine, and tear fluid also can be collected in this way, the term dried matrix spot is used as an overarching term. In this review, the focus is on advancements in the field made from 2017 up to 2023. In the first part reviews concerning the subject are discussed. After this, advancements made for clinical purposes are highlighted. Both targeted protein analyses, with and without the use of affinity extractions, as well as untargeted, global proteomic approaches are discussed. In the last part, both methodological advancements are being reviewed as well as the possibility to integrate sample preparation steps during the sample handling. The focus, of this so‐called smart sampling, is on the incorporation of cell separation, proteolysis, and antibody‐based affinity capture.
Determination of proteins from dried matrix spots using MS is an expanding research area. Mainly, the collected dried matrix sample is whole blood from a finger or heal prick, resulting in dried blood spots. However as other matrices such as plasma, serum, urine, and tear fluid also can be collected in this way, the term dried matrix spot is used as an overarching term. In this review, the focus is on advancements in the field made from 2017 up to 2023. In the first part reviews concerning the subject are discussed. After this, advancements made for clinical purposes are highlighted. Both targeted protein analyses, with and without the use of affinity extractions, as well as untargeted, global proteomic approaches are discussed. In the last part, both methodological advancements are being reviewed as well as the possibility to integrate sample preparation steps during the sample handling. The focus, of this so-called smart sampling, is on the incorporation of cell separation, proteolysis, and antibody-based affinity capture.
Determination of proteins from dried matrix spots using MS is an expanding research area. Mainly, the collected dried matrix sample is whole blood from a finger or heal prick, resulting in dried blood spots. However as other matrices such as plasma, serum, urine, and tear fluid also can be collected in this way, the term dried matrix spot is used as an overarching term. In this review, the focus is on advancements in the field made from 2017 up to 2023. In the first part reviews concerning the subject are discussed. After this, advancements made for clinical purposes are highlighted. Both targeted protein analyses, with and without the use of affinity extractions, as well as untargeted, global proteomic approaches are discussed. In the last part, both methodological advancements are being reviewed as well as the possibility to integrate sample preparation steps during the sample handling. The focus, of this so-called smart sampling, is on the incorporation of cell separation, proteolysis, and antibody-based affinity capture.Determination of proteins from dried matrix spots using MS is an expanding research area. Mainly, the collected dried matrix sample is whole blood from a finger or heal prick, resulting in dried blood spots. However as other matrices such as plasma, serum, urine, and tear fluid also can be collected in this way, the term dried matrix spot is used as an overarching term. In this review, the focus is on advancements in the field made from 2017 up to 2023. In the first part reviews concerning the subject are discussed. After this, advancements made for clinical purposes are highlighted. Both targeted protein analyses, with and without the use of affinity extractions, as well as untargeted, global proteomic approaches are discussed. In the last part, both methodological advancements are being reviewed as well as the possibility to integrate sample preparation steps during the sample handling. The focus, of this so-called smart sampling, is on the incorporation of cell separation, proteolysis, and antibody-based affinity capture.
Author Reubsaet, Léon
Halvorsen, Trine Grønhaug
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Keywords LC–MS determination
bioactive proteins
smart sampling
dried blood spots
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Snippet Determination of proteins from dried matrix spots using MS is an expanding research area. Mainly, the collected dried matrix sample is whole blood from a...
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SubjectTerms Affinity
Analytical chemistry
Antibodies
bioactive proteins
Biological activity
Biomedical research
Blood
blood serum
Dried Blood Spot Testing
dried blood spots
Humans
LC–MS determination
Liquid Chromatography-Mass Spectrometry
Mass spectrometry
Proteins
Proteins - analysis
proteolysis
Proteomics
Proteomics - methods
Sampling
separation
smart sampling
Specimen Handling
urine
Title Advancements in clinical approaches, analytical methods, and smart sampling for LC–MS‐based protein determination from dried matrix spots
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjssc.202400061
https://www.ncbi.nlm.nih.gov/pubmed/38726749
https://www.proquest.com/docview/3060661309
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Volume 47
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