Attrition of TCR Vα7.2+ CD161++ MAIT Cells in HIV-Tuberculosis Co-Infection Is Associated with Elevated Levels of PD-1 Expression

• Published in: PloS one Vol. 10; no. 4; p. e0124659
• Main Authors: Saeidi, Alireza, Tien Tien, Vicky L., Al-Batran, Rami, Al-Darraji, Haider A., Tan, Hong Y., Yong, Yean K., Ponnampalavanar, Sasheela, Barathan, Muttiah, Rukumani, Devi V., Ansari, Abdul W., Velu, Vijayakumar, Kamarulzaman, Adeeba, Larsson, Marie, Shankar, Esaki M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.04.2015; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Adult; AIDS; Anti-HIV Agents - pharmacology; Anti-HIV Agents - therapeutic use; Antitubercular Agents - pharmacology; Antitubercular Agents - therapeutic use; CD8-Positive T-Lymphocytes - cytology; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - metabolism; Cell Count; Coinfection - drug therapy; Coinfection - immunology; Cross-Sectional Studies; Exhaustion; Female; Flow cytometry; Gene Expression Regulation - drug effects; HIV; HIV Infections - drug therapy; HIV Infections - immunology; Human immunodeficiency virus; Humans; Immune response; Infections; Invariants; Lymphocytes; Male; NK Cell Lectin-Like Receptor Subfamily B - metabolism; Patients; Phenotype; Programmed Cell Death 1 Receptor - metabolism; Receptors, Antigen, T-Cell - metabolism; Receptors, CCR6 - metabolism; T cell receptors; Therapy; Tuberculosis; Tuberculosis - drug therapy; Tuberculosis - immunology; Viruses; Kuala Lumpur Malaysia; Malaysia

Mucosal-associated invariant T (MAIT) cells are evolutionarily conserved antimicrobial MR1-restricted CD8(+) T cells co-expressing the semi-invariant TCR Vα7.2, and are numerous in the blood and mucosal tissues of humans. MAIT cells appear to undergo exhaustion in chronic viral infections. However,...