An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z - Wang, Yan; Cobanoglu, Murat C.; Li, Jie; Hidvegi, Tunda; Hale, Pamela; Ewing, Michael; Chu, Andrew S.; Gong, Zhenwei; Muzumdar, Radhika; Pak, Stephen C.; Silverman, Gary A.; Bahar, Ivet; et al. (PloS one, 2019)
Keywords: a1-antitrypsin; Accumulation; alpha 1-Antitrypsin - drug effects; alpha 1-Antitrypsin - genetics; alpha 1-Antitrypsin - metabolism; alpha 1-Antitrypsin Deficiency - drug therapy; alpha 1-Antitrypsin Deficiency - genetics; Analogs; Animal models; Animals; Autophagy; Autophagy - drug effects; Biology and Life Sciences; Blood glucose; Caenorhabditis elegans - genetics; Caenorhabditis elegans - metabolism; Caenorhabditis elegans Proteins - metabolism; Cell culture; Cell death; Cell Line; Chemical compounds; Clinical medicine; Computation; Computer applications; Deficiency diseases; Degradation; Disease Models, Animal; Drug Discovery; Drugs; Fibrosis; Genes; Genomes; Glibenclamide; Glyburide - analogs & derivatives; Glyburide - pharmacology; Glyburide - therapeutic use; Glycoproteins; Humans; Insulin; Intracellular; Liver; Liver - metabolism; Liver Cirrhosis - metabolism; Liver diseases; Medicine; Medicine and Health Sciences; Mice; Mice, Transgenic; Pediatrics; Pharmacology; Proteins; Research and Analysis Methods; RNA Interference; RNA-mediated interference; Screening; Sulfonylurea; Pittsburgh Pennsylvania; United States--US; Missouri; Pennsylvania