A multibiomarker-based outcome risk stratification model for adult septic shock

• Published in: Critical care medicine Vol. 42; no. 4; p. 781
• Main Authors: Wong, Hector R, Lindsell, Christopher J, Pettilä, Ville, Meyer, Nuala J, Thair, Simone A, Karlsson, Sari, Russell, James A, Fjell, Christopher D, Boyd, John H, Ruokonen, Esko, Shashaty, Michael G S, Christie, Jason D, Hart, Kimberly W, Lahni, Patrick, Walley, Keith R
• Format: Journal Article
• Language: English
• Published: United States 01.04.2014
• Subjects: Adult; Age Factors; Aged; APACHE; Biomarkers; Chronic Disease; Decision Support Systems, Clinical; DNA Probes; Hospital Mortality; Humans; Intensive Care Units; Middle Aged; Prognosis; Risk Assessment; ROC Curve; Sensitivity and Specificity; Shock, Septic - genetics; Shock, Septic - mortality; Shock, Septic - physiopathology

Clinical trials in septic shock continue to fail due, in part, to inequitable and sometimes unknown distribution of baseline mortality risk between study arms. Investigators advocate that interventional trials in septic shock require effective outcome risk stratification. We derived and tested a mul...