The Mitochondrial Production of Reactive Oxygen Species in Relation to Aging and Pathology

• Published in: Annals of the New York Academy of Sciences Vol. 1011; no. 1; pp. 86 - 100
• Main Authors: GENOVA, MARIA LUISA, PICH, MILENA MERLO, BERNACCHIA, ANDREA, BIANCHI, CRISTINA, BIONDI, ANNALISA, BOVINA, CARLA, FALASCA, ANNA IDA, FORMIGGINI, GABRIELLA, CASTELLI, GIOVANNA PARENTI, LENAZ, GIORGIO
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2004
• Subjects: aging; Aging - physiology; Animals; Antioxidants - metabolism; bioenergetic defects; Blood Platelets - cytology; Blood Platelets - metabolism; Cattle; Cell Line; coenzyme Q; complex I; DNA, Mitochondrial - metabolism; Electron Transport - physiology; Electron Transport Complex I - genetics; Electron Transport Complex I - metabolism; Enzyme Inhibitors - metabolism; Humans; mitochondria; Mitochondria - metabolism; Myocardium - cytology; Myocardium - metabolism; oxidative stress; Oxygen - metabolism; Protein Subunits - genetics; Protein Subunits - metabolism; Quinones - metabolism; Rats; Reactive Oxygen Species - metabolism; superoxide

: Mitochondria are known to be strong producers of reactive oxygen species (ROS) and, at the same time, particularly susceptible to the oxidative damage produced by their action on lipids, proteins, and DNA. In particular, damage to mtDNA induces alterations to the polypeptides encoded by mtDNA in t...