The Role of the Rho/ROCK Pathway in Ang II and TGF-β1-Induced Atrial Remodeling

• Published in: PloS one Vol. 11; no. 9; p. e0161625
• Main Authors: Liu, Li-Juan, Yao, Feng-Juan, Lu, Gui-Hua, Xu, Cheng-Gui, Xu, Zhe, Tang, Kai, Cheng, Yun-Jiu, Gao, Xiu-Ren, Wu, Su-Hua
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.09.2016; Public Library of Science (PLoS)
• Subjects: Angiotensin; Angiotensin II; Angiotensin II - pharmacology; Animals; Atrial Fibrillation - metabolism; Atrial Remodeling - drug effects; Atrium; Biology and life sciences; Cardiac arrhythmia; Cardiology; Collagen; Connective tissue growth factor; Connective Tissue Growth Factor - genetics; Connective Tissue Growth Factor - metabolism; Connective tissues; Disease Models, Animal; Dogs; Female; Fibrillation; Fibroblasts; Gene expression; Growth factors; Kinases; Male; Medicine and Health Sciences; Research and Analysis Methods; rho GTP-Binding Proteins - genetics; rho GTP-Binding Proteins - metabolism; Rho-associated kinase; rho-Associated Kinases - genetics; rho-Associated Kinases - metabolism; RhoA protein; Rocks; Science; Signal transduction; Signal Transduction - drug effects; Signaling; Simvastatin; Smad2 protein; Transforming Growth Factor beta1 - pharmacology; Transforming growth factor-b1; Ultrasonic imaging; China

To study the role of the Rho/ROCK pathway in Ang II and TGF-β1-induced atrial remodeling. A canine atrial fibrillation (AF) model was established by rapid atrial pacing (RAP) of the left atrium. The roles of TGF-β1, the RhoA/ROCK signaling pathway and connective tissue growth factor (CTGF) in atrial...