Monoclonal antibodies to the V2 domain of MN-rgp120: fine mapping of epitopes and inhibition of α4β7 binding

• Published in: PloS one Vol. 7; no. 6; p. e39045
• Main Authors: Nakamura, Gerald R, Fonseca, Dora P A J, O'Rourke, Sara M, Vollrath, Aaron L, Berman, Phillip W
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.06.2012; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; AIDS; Amino acids; Antibodies, Monoclonal - immunology; Antibody Specificity; Antigens; Binding sites; Biology; Blocking; CD4 antigen; Correlation analysis; Epitope Mapping; Glycoprotein gp120; HIV; HIV Envelope Protein gp120 - chemistry; HIV Envelope Protein gp120 - immunology; Human immunodeficiency virus; Humans; Immunization; Infections; Integrins - immunology; Integrins - metabolism; Lymphocytes T; Medicine; Mice; Monoclonal antibodies; Mutagenesis, Site-Directed; Neutralization Tests; Protein Binding; Proteins; Vaccination; Vaccines; Virions; United States > US; North America; California

Recombinant gp120 (MN-rgp120) was a major component of the AIDSVAX B/E vaccine used in the RV144 trial. This was the first clinical trial to show that vaccination could prevent HIV infection in humans. A recent RV144 correlates of protection study found that protection correlated with the presence o...