The Vibrio cholerae var regulon encodes a metallo-β-lactamase and an antibiotic efflux pump, which are regulated by VarR, a LysR-type transcription factor

• Published in: PloS one Vol. 12; no. 9; p. e0184255
• Main Authors: Lin, Hong-Ting Victor, Massam-Wu, Teresa, Lin, Chen-Ping, Wang, Yen-Jen Anna, Shen, Yu-Chi, Lu, Wen-Jung, Hsu, Pang-Hung, Chen, Yu-Hou, Borges-Walmsley, Maria Ines, Walmsley, Adrian Robert
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.09.2017; Public Library of Science (PLoS)
• Subjects: Anti-Bacterial Agents - metabolism; Anti-Bacterial Agents - pharmacology; Antibiotic resistance; Antibiotics; Antimicrobial agents; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; Bacteria; Base Sequence; beta-Lactamases - genetics; Biology and Life Sciences; Carbapenems; Cephalosporins; Cholera; Deoxyribonucleic acid; DNA; DNA, Intergenic; Drug resistance; Drug Resistance, Bacterial; Drugs; E coli; Efflux; Epidemics; Food contamination & poisoning; Food science; Gene expression; Gene Expression Regulation, Bacterial; Gene regulation; Genes; Genes, Bacterial; Genomes; Hydrolysis; Kinetics; Medicine and Health Sciences; Membrane Transport Proteins - genetics; Meropenem; Metallography; Microbial Sensitivity Tests; Nucleotide sequence; Pathogens; Penicillin; Promoter Regions, Genetic; Protein Binding; Regulation; Regulon; Research and Analysis Methods; Spiramycin; Transcription Factors - metabolism; Transcription, Genetic; Vibrio cholerae - drug effects; Vibrio cholerae - genetics; Vibrio cholerae - metabolism; Waterborne diseases; Brazil; Taiwan

The genome sequence of V. cholerae O1 Biovar Eltor strain N16961 has revealed a putative antibiotic resistance (var) regulon that is predicted to encode a transcriptional activator (VarR), which is divergently transcribed relative to the putative resistance genes for both a metallo-β-lactamase (VarG...