The Vibrio cholerae var regulon encodes a metallo-β-lactamase and an antibiotic efflux pump, which are regulated by VarR, a LysR-type transcription factor - Lin, Hong-Ting Victor; Massam-Wu, Teresa; Lin, Chen-Ping; Wang, Yen-Jen Anna; Shen, Yu-Chi; Lu, Wen-Jung; Hsu, Pang-Hung; Chen, Yu-Hou; Borges-Walmsley, Maria Ines; Walmsley, Adrian Robert (PloS one, 2017)
Keywords: Anti-Bacterial Agents - metabolism; Anti-Bacterial Agents - pharmacology; Antibiotic resistance; Antibiotics; Antimicrobial agents; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; Bacteria; Base Sequence; beta-Lactamases - genetics; Biology and Life Sciences; Carbapenems; Cephalosporins; Cholera; Deoxyribonucleic acid; DNA; DNA, Intergenic; Drug resistance; Drug Resistance, Bacterial; Drugs; E coli; Efflux; Epidemics; Food contamination & poisoning; Food science; Gene expression; Gene Expression Regulation, Bacterial; Gene regulation; Genes; Genes, Bacterial; Genomes; Hydrolysis; Kinetics; Medicine and Health Sciences; Membrane Transport Proteins - genetics; Meropenem; Metallography; Microbial Sensitivity Tests; Nucleotide sequence; Pathogens; Penicillin; Promoter Regions, Genetic; Protein Binding; Regulation; Regulon; Research and Analysis Methods; Spiramycin; Transcription Factors - metabolism; Transcription, Genetic; Vibrio cholerae - drug effects; Vibrio cholerae - genetics; Vibrio cholerae - metabolism; Waterborne diseases; Brazil; Taiwan