Cyclooxygenase-2 Is Widely Expressed in Atherosclerotic Lesions Affecting Native and Transplanted Human Coronary Arteries and Colocalizes With Inducible Nitric Oxide Synthase and Nitrotyrosine Particularly in Macrophages

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 19; no. 3; pp. 646 - 655
• Main Authors: Baker, Christopher S.R, Hall, Roger J.C, Evans, Thomas J, Pomerance, Ariela, Maclouf, Jacques, Creminon, Christophe, Yacoub, Magdi H, Polak, Julia M
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.03.1999; Hagerstown, MD Lippincott
• Subjects: Animals; Arteriosclerosis - metabolism; Arteriosclerosis - pathology; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Coronary Artery Bypass; Coronary Vessels - cytology; Coronary Vessels - enzymology; Coronary Vessels - transplantation; Cyclooxygenase 2; Graft Survival - physiology; Humans; Isoenzymes - analysis; Isoenzymes - metabolism; Macrophages - chemistry; Macrophages - metabolism; Medical sciences; Membrane Proteins; Nitrates - analysis; Nitrates - metabolism; Nitric Oxide Synthase - analysis; Nitric Oxide Synthase - metabolism; Nitric Oxide Synthase Type II; Nitrogen Compounds - analysis; Nitrogen Compounds - metabolism; Prostaglandin-Endoperoxide Synthases - analysis; Prostaglandin-Endoperoxide Synthases - metabolism; Rabbits; Tyrosine - analysis; Tyrosine - metabolism; Heart; Human; Prostaglandin-endoperoxide synthase; Enzyme; Immunocytochemistry; Pathogenesis; Coronary artery; Cardiovascular disease; Transplantation; Homotransplantation; Nitric-oxide synthase; Vascular disease; Pathology; Surgery; Atherosclerosis; Oxidoreductases; Macrophage

Inflammation appears to have a major role in the development of atherosclerotic lesions affecting native and transplanted coronary arteries. The subsequent risk of plaque rupture and acute ischemic events correlates with the degree of inflammation and may be modified by aspirin, an anti-inflammatory...