Accurate assessment of alpha‐gal syndrome using cetuximab and bovine thyroglobulin‐specific IgE

• Published in: Molecular nutrition & food research Vol. 61; no. 10
• Main Authors: Sim, Da Woon, Lee, Jong Sun, Park, Kyung Hee, Jeong, Kyoung Yong, Ye, Young‐Min, Lee, Jae‐Hyun, Park, Jung‐Won
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.10.2017
• Subjects: Adolescent; Adult; Aged; Allergens - blood; Allergens - immunology; Allergic reactions; Allergies; Alpha‐gal syndrome; Animals; Atopy; beef; Bovine thyroglobulin‐specific IgE; Cattle; Cetuximab - blood; Cetuximab - immunology; Cetuximab‐specific IgE; Child; Child, Preschool; Component‐resolved diagnosis; Differentiation; Disaccharides - blood; Disaccharides - immunology; Epitopes; Female; Food Hypersensitivity - blood; Food Hypersensitivity - immunology; Galactose; Humans; hypersensitivity; Hypersensitivity (immediate); Immunoblotting; Immunoglobulin E; Immunoglobulin E - blood; Immunoglobulin E - immunology; Immunotherapy; Male; Meat; meat consumption; Middle Aged; Monoclonal antibodies; Patients; Pork; Red Meat; Retrospective Studies; Serum albumin; Silicon germanides; Streptavidin; Swine; Thyroglobulin; Thyroglobulin - blood; Thyroglobulin - immunology; Young Adult; α‐Gal; Bovine thyroglobulin-specific IgE; α-Gal; Component-resolved diagnosis; Alpha-gal syndrome; Cetuximab-specific IgE

Scope IgE against galactose‐α‐1,3‐galactose (α‐Gal) causes alpha‐gal syndrome. Bovine thyroglobulin (BTG) and cetuximab share this epitope. We aimed to determine the utility of specific IgE (sIgE) against cetuximab as compared to BTG for diagnosing alpha‐gal syndrome. Methods and results Twelve pati...