Uncommon Variants in FLG2 and NOD2 Are Associated with Atopic Dermatitis in the Ethiopian Population

• Published in: JID innovations Vol. 4; no. 4; p. 100284
• Main Authors: Wang, Sailan, Elmgren, Julia K., Eisfeldt, Jesper, Asad, Samina, Ek, Marlene, Bilcha, Kassahun, Befekadu, Annisa, Wahlgren, Carl-Fredrik, Nordenskjöld, Magnus, Taylan, Fulya, Tapia-Paez, Isabel, Bradley, Maria
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.07.2024; Elsevier
• Subjects: Atopic dermatitis; FLG2; Genetic association; Medicin och hälsovetenskap; NOD2; Original; Whole-genome sequencing; FLG2; WGS; AD; Atopic dermatitis; Whole-genome sequencing; NOD2; Genetic association

Loss-of-function variants in the FLG gene have been identified as the strongest cause of susceptibility to atopic dermatitis (AD) in Europeans and Asians. However, very little is known about the genetic etiology behind AD in African populations, where the prevalence of AD is notably high. We sought...