Translation of the circular RNA circβ-catenin promotes liver cancer cell growth through activation of the Wnt pathway
Circular RNAs are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. In the current study, we evaluate the function of a novel circRNA derived from the β-catenin gene locus, circβ-catenin. Circβ-catenin is predominantly localized in the cytoplasm and displays resi...
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| Published in | Genome Biology Vol. 20; no. 1; p. 84 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
BioMed Central
26.04.2019
BMC |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Circular RNAs are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. In the current study, we evaluate the function of a novel circRNA derived from the β-catenin gene locus, circβ-catenin.
Circβ-catenin is predominantly localized in the cytoplasm and displays resistance to RNase-R treatment. We find that circβ-catenin is highly expressed in liver cancer tissues when compared to adjacent normal tissues. Silencing of circβ-catenin significantly suppresses malignant phenotypes in vitro and in vivo, and knockdown of this circRNA reduces the protein level of β-catenin without affecting its mRNA level. We show that circβ-catenin affects a wide spectrum of Wnt pathway-related genes, and furthermore, circβ-catenin produces a novel 370-amino acid β-catenin isoform that uses the start codon as the linear β-catenin mRNA transcript and translation is terminated at a new stop codon created by circularization. We find that this novel isoform can stabilize full-length β-catenin by antagonizing GSK3β-induced β-catenin phosphorylation and degradation, leading to activation of the Wnt pathway.
Our findings illustrate a non-canonical function of circRNA in modulating liver cancer cell growth through the Wnt pathway, which can provide novel mechanistic insights into the underlying mechanisms of hepatocellular carcinoma. |
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| AbstractList | BackgroundCircular RNAs are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. In the current study, we evaluate the function of a novel circRNA derived from the β-catenin gene locus, circβ-catenin.ResultsCircβ-catenin is predominantly localized in the cytoplasm and displays resistance to RNase-R treatment. We find that circβ-catenin is highly expressed in liver cancer tissues when compared to adjacent normal tissues. Silencing of circβ-catenin significantly suppresses malignant phenotypes in vitro and in vivo, and knockdown of this circRNA reduces the protein level of β-catenin without affecting its mRNA level. We show that circβ-catenin affects a wide spectrum of Wnt pathway-related genes, and furthermore, circβ-catenin produces a novel 370-amino acid β-catenin isoform that uses the start codon as the linear β-catenin mRNA transcript and translation is terminated at a new stop codon created by circularization. We find that this novel isoform can stabilize full-length β-catenin by antagonizing GSK3β-induced β-catenin phosphorylation and degradation, leading to activation of the Wnt pathway.ConclusionsOur findings illustrate a non-canonical function of circRNA in modulating liver cancer cell growth through the Wnt pathway, which can provide novel mechanistic insights into the underlying mechanisms of hepatocellular carcinoma. Circular RNAs are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. In the current study, we evaluate the function of a novel circRNA derived from the β-catenin gene locus, circβ-catenin.BACKGROUNDCircular RNAs are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. In the current study, we evaluate the function of a novel circRNA derived from the β-catenin gene locus, circβ-catenin.Circβ-catenin is predominantly localized in the cytoplasm and displays resistance to RNase-R treatment. We find that circβ-catenin is highly expressed in liver cancer tissues when compared to adjacent normal tissues. Silencing of circβ-catenin significantly suppresses malignant phenotypes in vitro and in vivo, and knockdown of this circRNA reduces the protein level of β-catenin without affecting its mRNA level. We show that circβ-catenin affects a wide spectrum of Wnt pathway-related genes, and furthermore, circβ-catenin produces a novel 370-amino acid β-catenin isoform that uses the start codon as the linear β-catenin mRNA transcript and translation is terminated at a new stop codon created by circularization. We find that this novel isoform can stabilize full-length β-catenin by antagonizing GSK3β-induced β-catenin phosphorylation and degradation, leading to activation of the Wnt pathway.RESULTSCircβ-catenin is predominantly localized in the cytoplasm and displays resistance to RNase-R treatment. We find that circβ-catenin is highly expressed in liver cancer tissues when compared to adjacent normal tissues. Silencing of circβ-catenin significantly suppresses malignant phenotypes in vitro and in vivo, and knockdown of this circRNA reduces the protein level of β-catenin without affecting its mRNA level. We show that circβ-catenin affects a wide spectrum of Wnt pathway-related genes, and furthermore, circβ-catenin produces a novel 370-amino acid β-catenin isoform that uses the start codon as the linear β-catenin mRNA transcript and translation is terminated at a new stop codon created by circularization. We find that this novel isoform can stabilize full-length β-catenin by antagonizing GSK3β-induced β-catenin phosphorylation and degradation, leading to activation of the Wnt pathway.Our findings illustrate a non-canonical function of circRNA in modulating liver cancer cell growth through the Wnt pathway, which can provide novel mechanistic insights into the underlying mechanisms of hepatocellular carcinoma.CONCLUSIONSOur findings illustrate a non-canonical function of circRNA in modulating liver cancer cell growth through the Wnt pathway, which can provide novel mechanistic insights into the underlying mechanisms of hepatocellular carcinoma. BACKGROUND: Circular RNAs are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. In the current study, we evaluate the function of a novel circRNA derived from the β-catenin gene locus, circβ-catenin. RESULTS: Circβ-catenin is predominantly localized in the cytoplasm and displays resistance to RNase-R treatment. We find that circβ-catenin is highly expressed in liver cancer tissues when compared to adjacent normal tissues. Silencing of circβ-catenin significantly suppresses malignant phenotypes in vitro and in vivo, and knockdown of this circRNA reduces the protein level of β-catenin without affecting its mRNA level. We show that circβ-catenin affects a wide spectrum of Wnt pathway-related genes, and furthermore, circβ-catenin produces a novel 370-amino acid β-catenin isoform that uses the start codon as the linear β-catenin mRNA transcript and translation is terminated at a new stop codon created by circularization. We find that this novel isoform can stabilize full-length β-catenin by antagonizing GSK3β-induced β-catenin phosphorylation and degradation, leading to activation of the Wnt pathway. CONCLUSIONS: Our findings illustrate a non-canonical function of circRNA in modulating liver cancer cell growth through the Wnt pathway, which can provide novel mechanistic insights into the underlying mechanisms of hepatocellular carcinoma. Abstract Background Circular RNAs are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. In the current study, we evaluate the function of a novel circRNA derived from the β-catenin gene locus, circβ-catenin. Results Circβ-catenin is predominantly localized in the cytoplasm and displays resistance to RNase-R treatment. We find that circβ-catenin is highly expressed in liver cancer tissues when compared to adjacent normal tissues. Silencing of circβ-catenin significantly suppresses malignant phenotypes in vitro and in vivo, and knockdown of this circRNA reduces the protein level of β-catenin without affecting its mRNA level. We show that circβ-catenin affects a wide spectrum of Wnt pathway-related genes, and furthermore, circβ-catenin produces a novel 370-amino acid β-catenin isoform that uses the start codon as the linear β-catenin mRNA transcript and translation is terminated at a new stop codon created by circularization. We find that this novel isoform can stabilize full-length β-catenin by antagonizing GSK3β-induced β-catenin phosphorylation and degradation, leading to activation of the Wnt pathway. Conclusions Our findings illustrate a non-canonical function of circRNA in modulating liver cancer cell growth through the Wnt pathway, which can provide novel mechanistic insights into the underlying mechanisms of hepatocellular carcinoma. Circular RNAs are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. In the current study, we evaluate the function of a novel circRNA derived from the β-catenin gene locus, circβ-catenin. Circβ-catenin is predominantly localized in the cytoplasm and displays resistance to RNase-R treatment. We find that circβ-catenin is highly expressed in liver cancer tissues when compared to adjacent normal tissues. Silencing of circβ-catenin significantly suppresses malignant phenotypes in vitro and in vivo, and knockdown of this circRNA reduces the protein level of β-catenin without affecting its mRNA level. We show that circβ-catenin affects a wide spectrum of Wnt pathway-related genes, and furthermore, circβ-catenin produces a novel 370-amino acid β-catenin isoform that uses the start codon as the linear β-catenin mRNA transcript and translation is terminated at a new stop codon created by circularization. We find that this novel isoform can stabilize full-length β-catenin by antagonizing GSK3β-induced β-catenin phosphorylation and degradation, leading to activation of the Wnt pathway. Our findings illustrate a non-canonical function of circRNA in modulating liver cancer cell growth through the Wnt pathway, which can provide novel mechanistic insights into the underlying mechanisms of hepatocellular carcinoma. |
| ArticleNumber | 84 |
| Author | Wong, Cheuk-Wa Liang, Pu-Ping Zhang, Qi Waye, Mary Miu-Yee Fu, Wei-Ming Cao, Ye Tsui, Stephen Kwok-Wing Liang, Wei-Cheng Zhang, Jin-Fang Shi, Mai Rao, Shi-Tao |
| Author_xml | – sequence: 1 givenname: Wei-Cheng surname: Liang fullname: Liang, Wei-Cheng – sequence: 2 givenname: Cheuk-Wa surname: Wong fullname: Wong, Cheuk-Wa – sequence: 3 givenname: Pu-Ping surname: Liang fullname: Liang, Pu-Ping – sequence: 4 givenname: Mai surname: Shi fullname: Shi, Mai – sequence: 5 givenname: Ye surname: Cao fullname: Cao, Ye – sequence: 6 givenname: Shi-Tao surname: Rao fullname: Rao, Shi-Tao – sequence: 7 givenname: Stephen Kwok-Wing surname: Tsui fullname: Tsui, Stephen Kwok-Wing – sequence: 8 givenname: Mary Miu-Yee surname: Waye fullname: Waye, Mary Miu-Yee – sequence: 9 givenname: Qi surname: Zhang fullname: Zhang, Qi – sequence: 10 givenname: Wei-Ming surname: Fu fullname: Fu, Wei-Ming – sequence: 11 givenname: Jin-Fang surname: Zhang fullname: Zhang, Jin-Fang |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31027518$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/onc.2010.236 10.1002/hep.29270 10.1016/j.semcancer.2010.12.010 10.1101/gad.244772.114 10.1016/j.molcel.2017.02.017 10.1016/j.celrep.2017.08.012 10.1038/nsmb.2959 10.1093/jnci/djx166 10.1046/j.1440-1746.2002.02774.x 10.1371/journal.pone.0090859 10.1038/onc.2017.89 10.1261/rna.048272.114 10.1158/0008-5472.CAN-16-1883 10.1016/j.celrep.2014.12.002 10.1126/science.aad4076 10.1038/s41388-017-0041-y 10.1159/000012024 10.1261/rna.035667.112 10.1038/s41388-017-0019-9 10.1016/j.molcel.2017.02.021 10.1261/rna.043687.113 10.1038/srep16435 10.1038/nature11928 10.1186/s13059-019-1685-4 10.1038/onc.2015.460 10.5306/wjco.v2.i8.311 10.4251/wjgo.v2.i9.348 10.1002/1097-0142(20010701)92:1<136::AID-CNCR1301>3.0.CO;2-R 10.1371/journal.pone.0030733 10.1038/nature14346 10.4161/rna.29356 10.1016/j.molcel.2014.08.019 10.1016/j.cell.2016.03.020 |
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| References | P Glazar (1685_CR34) 2014; 20 W Yang (1685_CR19) 2016; 35 T Suzuki (1685_CR8) 2002; 17 CM Wong (1685_CR9) 2001; 92 PL Wang (1685_CR13) 2014; 9 Yibing Yang (1685_CR23) 2017; 110 D Han (1685_CR28) 2017; 66 M Zhang (1685_CR24) 2018; 37 1685_CR33 H Climente-Gonzalez (1685_CR29) 2017; 20 J Guarnerio (1685_CR26) 2016; 165 Z Li (1685_CR20) 2015; 22 N Abe (1685_CR21) 2015; 5 Y Wang (1685_CR30) 2015; 21 S Fatima (1685_CR1) 2011; 2 S Starke (1685_CR15) 2015; 10 WR Jeck (1685_CR16) 2013; 19 I Legnini (1685_CR25) 2017; 66 N Nishida (1685_CR11) 1994; 54 D Lauressergues (1685_CR32) 2015; 520 WC Liang (1685_CR4) 2018; 37 S Memczak (1685_CR17) 2013; 495 L Rossi (1685_CR2) 2010; 2 KN Nejak-Bowen (1685_CR7) 2011; 21 J Salzman (1685_CR12) 2012; 7 BR Nelson (1685_CR31) 2016; 351 WC Liang (1685_CR5) 2014; 11 WH Lien (1685_CR6) 2014; 28 R Ashwal-Fluss (1685_CR14) 2014; 56 L Chen (1685_CR18) 2017; 36 S Whittaker (1685_CR3) 2010; 29 NR Pamudurti (1685_CR22) 2017; 66 S Kawate (1685_CR10) 1999; 57 KY Hsiao (1685_CR27) 2017; 77 |
| References_xml | – volume: 29 start-page: 4989 year: 2010 ident: 1685_CR3 publication-title: Oncogene doi: 10.1038/onc.2010.236 – volume: 66 start-page: 1151 year: 2017 ident: 1685_CR28 publication-title: Hepatology doi: 10.1002/hep.29270 – volume: 21 start-page: 44 year: 2011 ident: 1685_CR7 publication-title: Semin Cancer Biol doi: 10.1016/j.semcancer.2010.12.010 – volume: 28 start-page: 1517 year: 2014 ident: 1685_CR6 publication-title: Genes Dev doi: 10.1101/gad.244772.114 – volume: 66 start-page: 22 year: 2017 ident: 1685_CR25 publication-title: Mol Cell doi: 10.1016/j.molcel.2017.02.017 – volume: 20 start-page: 2215 year: 2017 ident: 1685_CR29 publication-title: Cell Rep doi: 10.1016/j.celrep.2017.08.012 – volume: 22 start-page: 256 year: 2015 ident: 1685_CR20 publication-title: Nat Struct Mol Biol doi: 10.1038/nsmb.2959 – volume: 110 start-page: 304 issue: 3 year: 2017 ident: 1685_CR23 publication-title: JNCI: Journal of the National Cancer Institute doi: 10.1093/jnci/djx166 – volume: 17 start-page: 994 year: 2002 ident: 1685_CR8 publication-title: J Gastroenterol Hepatol doi: 10.1046/j.1440-1746.2002.02774.x – volume: 9 start-page: e90859 year: 2014 ident: 1685_CR13 publication-title: PLoS One doi: 10.1371/journal.pone.0090859 – volume: 36 start-page: 4551 year: 2017 ident: 1685_CR18 publication-title: Oncogene doi: 10.1038/onc.2017.89 – volume: 21 start-page: 172 year: 2015 ident: 1685_CR30 publication-title: RNA doi: 10.1261/rna.048272.114 – volume: 77 start-page: 2339 year: 2017 ident: 1685_CR27 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-16-1883 – volume: 10 start-page: 103 year: 2015 ident: 1685_CR15 publication-title: Cell Rep doi: 10.1016/j.celrep.2014.12.002 – volume: 351 start-page: 271 year: 2016 ident: 1685_CR31 publication-title: Science doi: 10.1126/science.aad4076 – volume: 37 start-page: 1445 year: 2018 ident: 1685_CR4 publication-title: Oncogene doi: 10.1038/s41388-017-0041-y – volume: 57 start-page: 157 year: 1999 ident: 1685_CR10 publication-title: Oncology doi: 10.1159/000012024 – volume: 19 start-page: 141 year: 2013 ident: 1685_CR16 publication-title: RNA doi: 10.1261/rna.035667.112 – volume: 37 start-page: 1805 year: 2018 ident: 1685_CR24 publication-title: Oncogene doi: 10.1038/s41388-017-0019-9 – volume: 66 start-page: 9 year: 2017 ident: 1685_CR22 publication-title: Mol Cell doi: 10.1016/j.molcel.2017.02.021 – volume: 20 start-page: 1666 year: 2014 ident: 1685_CR34 publication-title: RNA doi: 10.1261/rna.043687.113 – volume: 5 start-page: 16435 year: 2015 ident: 1685_CR21 publication-title: Sci Rep doi: 10.1038/srep16435 – volume: 495 start-page: 333 year: 2013 ident: 1685_CR17 publication-title: Nature doi: 10.1038/nature11928 – ident: 1685_CR33 doi: 10.1186/s13059-019-1685-4 – volume: 35 start-page: 3919 year: 2016 ident: 1685_CR19 publication-title: Oncogene doi: 10.1038/onc.2015.460 – volume: 2 start-page: 311 year: 2011 ident: 1685_CR1 publication-title: World J Clin Oncol doi: 10.5306/wjco.v2.i8.311 – volume: 2 start-page: 348 year: 2010 ident: 1685_CR2 publication-title: World J Gastrointest Oncol doi: 10.4251/wjgo.v2.i9.348 – volume: 92 start-page: 136 year: 2001 ident: 1685_CR9 publication-title: Cancer doi: 10.1002/1097-0142(20010701)92:1<136::AID-CNCR1301>3.0.CO;2-R – volume: 7 start-page: e30733 year: 2012 ident: 1685_CR12 publication-title: PLoS One doi: 10.1371/journal.pone.0030733 – volume: 520 start-page: 90 year: 2015 ident: 1685_CR32 publication-title: Nature doi: 10.1038/nature14346 – volume: 54 start-page: 3107 year: 1994 ident: 1685_CR11 publication-title: Cancer Res – volume: 11 start-page: 845 year: 2014 ident: 1685_CR5 publication-title: RNA Biol doi: 10.4161/rna.29356 – volume: 56 start-page: 55 year: 2014 ident: 1685_CR14 publication-title: Mol Cell doi: 10.1016/j.molcel.2014.08.019 – volume: 165 start-page: 289 year: 2016 ident: 1685_CR26 publication-title: Cell doi: 10.1016/j.cell.2016.03.020 |
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| Snippet | Circular RNAs are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. In the current study, we evaluate the function of a... BackgroundCircular RNAs are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. In the current study, we evaluate the... BACKGROUND: Circular RNAs are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. In the current study, we evaluate the... Abstract Background Circular RNAs are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. In the current study, we evaluate... |
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| SubjectTerms | Amino acids Animals beta catenin beta Catenin - genetics Bioinformatics Carcinogenesis Carcinoma, Hepatocellular - etiology Cell activation Cell growth Cell Line, Tumor Cell Movement Circular RNA Coding capacity Cytoplasm eukaryotic cells Gene expression Gene Knockdown Techniques Glycogen Synthase Kinase 3 beta - metabolism Hepatocellular carcinoma Hepatocytes hepatoma Humans Kinases Ligands Liver cancer Liver Neoplasms - etiology loci messenger RNA Mice, Nude MicroRNAs Mortality neoplasm cells Neoplasm Metastasis Non-coding RNA Online data bases phenotype Phenotypes Phosphorylation protein content Proteins Ribonuclease RNA - metabolism RNA, Circular start codon Stop codon tissues Transcription Translation translation (genetics) Tumorigenesis Wnt pathway Wnt protein Wnt Signaling Pathway β-Catenin |
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