Human uncultured adipose-derived stromal vascular fraction shows therapeutic potential against osteoarthritis in immunodeficient rats via direct effects of transplanted M2 macrophages
The uncultured adipose-derived stromal vascular fraction (SVF), consisting of adipose-derived stromal cells (ADSCs), M2 macrophages (M2Φ) and others, has shown therapeutic potential against osteoarthritis (OA), however, the mechanisms underlying its therapeutic effects remain unclear. Therefore, thi...
Saved in:
| Published in | Stem cell research & therapy Vol. 15; no. 1; pp. 325 - 13 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
BioMed Central Ltd
27.09.2024
BioMed Central BMC |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The uncultured adipose-derived stromal vascular fraction (SVF), consisting of adipose-derived stromal cells (ADSCs), M2 macrophages (M2Φ) and others, has shown therapeutic potential against osteoarthritis (OA), however, the mechanisms underlying its therapeutic effects remain unclear. Therefore, this study investigated the effects of the SVF on OA in a human-immunodeficient rat xenotransplantation model.
OA model was induced in the knees of female immunodeficient rats by destabilization of the medial meniscus. Immediately after the surgery, human SVF (1 × 10
), ADSCs (1 × 10
), or phosphate buffered saline as a control group were transplanted into the knees. At 4 and 8 weeks postoperatively, OA progression and synovitis were analyzed by macroscopic and histological analyses, and the expression of collagen II, SOX9, MMP-13, ADAMTS-5, F4/80, CD86 (M1), CD163 (M2), and human nuclear antigen (hNA) were evaluated immunohistochemically. In vitro, flow cytometry was performed to collect CD163-positive cells as M2Φ from the SVF. Chondrocyte pellets (1 × 10
) were co-cultured with SVF (1 × 10
), M2Φ (1 × 10
), and ADSCs (1 × 10
) or alone as a control group, and the pellet size was compared. TGF-β, IL-10 and MMP-13 concentrations in the medium were evaluated using enzyme-linked immunosorbent assay.
In comparison with the control and ADSC groups, the SVF group showed significantly slower OA progression and less synovitis with higher expression of collagen II and SOX9, lower expression of MMP-13 and ADAMTS-5, and lower F4/80 and M1/M2 ratio in the synovium. Only the SVF group showed partial expression of hNA-, CD163-, and F4/80-positive cells in the rat synovium. In vitro, the SVF, M2Φ, ADSC and control groups, in that order, showed larger pellet sizes, higher TGF-β and IL-10, and lower MMP-13 concentrations.
The M2Φ in the transplanted SVF directly affected recipient tissue, enhancing the secretion of growth factors and chondrocyte-protecting cytokines, and partially improving chondrocytes and joint homeostasis. These findings indicate that the SVF is as an effective option for regenerative therapy for OA, with mechanisms different from those of ADSCs. |
|---|---|
| AbstractList | The uncultured adipose-derived stromal vascular fraction (SVF), consisting of adipose-derived stromal cells (ADSCs), M2 macrophages (M2Φ) and others, has shown therapeutic potential against osteoarthritis (OA), however, the mechanisms underlying its therapeutic effects remain unclear. Therefore, this study investigated the effects of the SVF on OA in a human-immunodeficient rat xenotransplantation model. OA model was induced in the knees of female immunodeficient rats by destabilization of the medial meniscus. Immediately after the surgery, human SVF (1 x 10.sup.5), ADSCs (1 x 10.sup.4), or phosphate buffered saline as a control group were transplanted into the knees. At 4 and 8 weeks postoperatively, OA progression and synovitis were analyzed by macroscopic and histological analyses, and the expression of collagen II, SOX9, MMP-13, ADAMTS-5, F4/80, CD86 (M1), CD163 (M2), and human nuclear antigen (hNA) were evaluated immunohistochemically. In vitro, flow cytometry was performed to collect CD163-positive cells as M2Φ from the SVF. Chondrocyte pellets (1 x 10.sup.5) were co-cultured with SVF (1 x 10.sup.5), M2Φ (1 x 10.sup.4), and ADSCs (1 x 10.sup.4) or alone as a control group, and the pellet size was compared. TGF-[beta], IL-10 and MMP-13 concentrations in the medium were evaluated using enzyme-linked immunosorbent assay. In comparison with the control and ADSC groups, the SVF group showed significantly slower OA progression and less synovitis with higher expression of collagen II and SOX9, lower expression of MMP-13 and ADAMTS-5, and lower F4/80 and M1/M2 ratio in the synovium. Only the SVF group showed partial expression of hNA-, CD163-, and F4/80-positive cells in the rat synovium. In vitro, the SVF, M2Φ, ADSC and control groups, in that order, showed larger pellet sizes, higher TGF-[beta] and IL-10, and lower MMP-13 concentrations. The M2Φ in the transplanted SVF directly affected recipient tissue, enhancing the secretion of growth factors and chondrocyte-protecting cytokines, and partially improving chondrocytes and joint homeostasis. These findings indicate that the SVF is as an effective option for regenerative therapy for OA, with mechanisms different from those of ADSCs. The uncultured adipose-derived stromal vascular fraction (SVF), consisting of adipose-derived stromal cells (ADSCs), M2 macrophages (M2Φ) and others, has shown therapeutic potential against osteoarthritis (OA), however, the mechanisms underlying its therapeutic effects remain unclear. Therefore, this study investigated the effects of the SVF on OA in a human-immunodeficient rat xenotransplantation model. OA model was induced in the knees of female immunodeficient rats by destabilization of the medial meniscus. Immediately after the surgery, human SVF (1 × 10 ), ADSCs (1 × 10 ), or phosphate buffered saline as a control group were transplanted into the knees. At 4 and 8 weeks postoperatively, OA progression and synovitis were analyzed by macroscopic and histological analyses, and the expression of collagen II, SOX9, MMP-13, ADAMTS-5, F4/80, CD86 (M1), CD163 (M2), and human nuclear antigen (hNA) were evaluated immunohistochemically. In vitro, flow cytometry was performed to collect CD163-positive cells as M2Φ from the SVF. Chondrocyte pellets (1 × 10 ) were co-cultured with SVF (1 × 10 ), M2Φ (1 × 10 ), and ADSCs (1 × 10 ) or alone as a control group, and the pellet size was compared. TGF-β, IL-10 and MMP-13 concentrations in the medium were evaluated using enzyme-linked immunosorbent assay. In comparison with the control and ADSC groups, the SVF group showed significantly slower OA progression and less synovitis with higher expression of collagen II and SOX9, lower expression of MMP-13 and ADAMTS-5, and lower F4/80 and M1/M2 ratio in the synovium. Only the SVF group showed partial expression of hNA-, CD163-, and F4/80-positive cells in the rat synovium. In vitro, the SVF, M2Φ, ADSC and control groups, in that order, showed larger pellet sizes, higher TGF-β and IL-10, and lower MMP-13 concentrations. The M2Φ in the transplanted SVF directly affected recipient tissue, enhancing the secretion of growth factors and chondrocyte-protecting cytokines, and partially improving chondrocytes and joint homeostasis. These findings indicate that the SVF is as an effective option for regenerative therapy for OA, with mechanisms different from those of ADSCs. Background The uncultured adipose-derived stromal vascular fraction (SVF), consisting of adipose-derived stromal cells (ADSCs), M2 macrophages (M2Φ) and others, has shown therapeutic potential against osteoarthritis (OA), however, the mechanisms underlying its therapeutic effects remain unclear. Therefore, this study investigated the effects of the SVF on OA in a human-immunodeficient rat xenotransplantation model. Methods OA model was induced in the knees of female immunodeficient rats by destabilization of the medial meniscus. Immediately after the surgery, human SVF (1 x 10.sup.5), ADSCs (1 x 10.sup.4), or phosphate buffered saline as a control group were transplanted into the knees. At 4 and 8 weeks postoperatively, OA progression and synovitis were analyzed by macroscopic and histological analyses, and the expression of collagen II, SOX9, MMP-13, ADAMTS-5, F4/80, CD86 (M1), CD163 (M2), and human nuclear antigen (hNA) were evaluated immunohistochemically. In vitro, flow cytometry was performed to collect CD163-positive cells as M2Φ from the SVF. Chondrocyte pellets (1 x 10.sup.5) were co-cultured with SVF (1 x 10.sup.5), M2Φ (1 x 10.sup.4), and ADSCs (1 x 10.sup.4) or alone as a control group, and the pellet size was compared. TGF-[beta], IL-10 and MMP-13 concentrations in the medium were evaluated using enzyme-linked immunosorbent assay. Results In comparison with the control and ADSC groups, the SVF group showed significantly slower OA progression and less synovitis with higher expression of collagen II and SOX9, lower expression of MMP-13 and ADAMTS-5, and lower F4/80 and M1/M2 ratio in the synovium. Only the SVF group showed partial expression of hNA-, CD163-, and F4/80-positive cells in the rat synovium. In vitro, the SVF, M2Φ, ADSC and control groups, in that order, showed larger pellet sizes, higher TGF-[beta] and IL-10, and lower MMP-13 concentrations. Conclusions The M2Φ in the transplanted SVF directly affected recipient tissue, enhancing the secretion of growth factors and chondrocyte-protecting cytokines, and partially improving chondrocytes and joint homeostasis. These findings indicate that the SVF is as an effective option for regenerative therapy for OA, with mechanisms different from those of ADSCs. Keywords: Stromal vascular fraction, M2 macrophages, Adipose-derived stromal cells, Osteoarthritis, Synovitis, Xenotransplantation, Rat model The uncultured adipose-derived stromal vascular fraction (SVF), consisting of adipose-derived stromal cells (ADSCs), M2 macrophages (M2Φ) and others, has shown therapeutic potential against osteoarthritis (OA), however, the mechanisms underlying its therapeutic effects remain unclear. Therefore, this study investigated the effects of the SVF on OA in a human-immunodeficient rat xenotransplantation model.BACKGROUNDThe uncultured adipose-derived stromal vascular fraction (SVF), consisting of adipose-derived stromal cells (ADSCs), M2 macrophages (M2Φ) and others, has shown therapeutic potential against osteoarthritis (OA), however, the mechanisms underlying its therapeutic effects remain unclear. Therefore, this study investigated the effects of the SVF on OA in a human-immunodeficient rat xenotransplantation model.OA model was induced in the knees of female immunodeficient rats by destabilization of the medial meniscus. Immediately after the surgery, human SVF (1 × 105), ADSCs (1 × 104), or phosphate buffered saline as a control group were transplanted into the knees. At 4 and 8 weeks postoperatively, OA progression and synovitis were analyzed by macroscopic and histological analyses, and the expression of collagen II, SOX9, MMP-13, ADAMTS-5, F4/80, CD86 (M1), CD163 (M2), and human nuclear antigen (hNA) were evaluated immunohistochemically. In vitro, flow cytometry was performed to collect CD163-positive cells as M2Φ from the SVF. Chondrocyte pellets (1 × 105) were co-cultured with SVF (1 × 105), M2Φ (1 × 104), and ADSCs (1 × 104) or alone as a control group, and the pellet size was compared. TGF-β, IL-10 and MMP-13 concentrations in the medium were evaluated using enzyme-linked immunosorbent assay.METHODSOA model was induced in the knees of female immunodeficient rats by destabilization of the medial meniscus. Immediately after the surgery, human SVF (1 × 105), ADSCs (1 × 104), or phosphate buffered saline as a control group were transplanted into the knees. At 4 and 8 weeks postoperatively, OA progression and synovitis were analyzed by macroscopic and histological analyses, and the expression of collagen II, SOX9, MMP-13, ADAMTS-5, F4/80, CD86 (M1), CD163 (M2), and human nuclear antigen (hNA) were evaluated immunohistochemically. In vitro, flow cytometry was performed to collect CD163-positive cells as M2Φ from the SVF. Chondrocyte pellets (1 × 105) were co-cultured with SVF (1 × 105), M2Φ (1 × 104), and ADSCs (1 × 104) or alone as a control group, and the pellet size was compared. TGF-β, IL-10 and MMP-13 concentrations in the medium were evaluated using enzyme-linked immunosorbent assay.In comparison with the control and ADSC groups, the SVF group showed significantly slower OA progression and less synovitis with higher expression of collagen II and SOX9, lower expression of MMP-13 and ADAMTS-5, and lower F4/80 and M1/M2 ratio in the synovium. Only the SVF group showed partial expression of hNA-, CD163-, and F4/80-positive cells in the rat synovium. In vitro, the SVF, M2Φ, ADSC and control groups, in that order, showed larger pellet sizes, higher TGF-β and IL-10, and lower MMP-13 concentrations.RESULTSIn comparison with the control and ADSC groups, the SVF group showed significantly slower OA progression and less synovitis with higher expression of collagen II and SOX9, lower expression of MMP-13 and ADAMTS-5, and lower F4/80 and M1/M2 ratio in the synovium. Only the SVF group showed partial expression of hNA-, CD163-, and F4/80-positive cells in the rat synovium. In vitro, the SVF, M2Φ, ADSC and control groups, in that order, showed larger pellet sizes, higher TGF-β and IL-10, and lower MMP-13 concentrations.The M2Φ in the transplanted SVF directly affected recipient tissue, enhancing the secretion of growth factors and chondrocyte-protecting cytokines, and partially improving chondrocytes and joint homeostasis. These findings indicate that the SVF is as an effective option for regenerative therapy for OA, with mechanisms different from those of ADSCs.CONCLUSIONSThe M2Φ in the transplanted SVF directly affected recipient tissue, enhancing the secretion of growth factors and chondrocyte-protecting cytokines, and partially improving chondrocytes and joint homeostasis. These findings indicate that the SVF is as an effective option for regenerative therapy for OA, with mechanisms different from those of ADSCs. Abstract Background The uncultured adipose-derived stromal vascular fraction (SVF), consisting of adipose-derived stromal cells (ADSCs), M2 macrophages (M2Φ) and others, has shown therapeutic potential against osteoarthritis (OA), however, the mechanisms underlying its therapeutic effects remain unclear. Therefore, this study investigated the effects of the SVF on OA in a human-immunodeficient rat xenotransplantation model. Methods OA model was induced in the knees of female immunodeficient rats by destabilization of the medial meniscus. Immediately after the surgery, human SVF (1 × 105), ADSCs (1 × 104), or phosphate buffered saline as a control group were transplanted into the knees. At 4 and 8 weeks postoperatively, OA progression and synovitis were analyzed by macroscopic and histological analyses, and the expression of collagen II, SOX9, MMP-13, ADAMTS-5, F4/80, CD86 (M1), CD163 (M2), and human nuclear antigen (hNA) were evaluated immunohistochemically. In vitro, flow cytometry was performed to collect CD163-positive cells as M2Φ from the SVF. Chondrocyte pellets (1 × 105) were co-cultured with SVF (1 × 105), M2Φ (1 × 104), and ADSCs (1 × 104) or alone as a control group, and the pellet size was compared. TGF-β, IL-10 and MMP-13 concentrations in the medium were evaluated using enzyme-linked immunosorbent assay. Results In comparison with the control and ADSC groups, the SVF group showed significantly slower OA progression and less synovitis with higher expression of collagen II and SOX9, lower expression of MMP-13 and ADAMTS-5, and lower F4/80 and M1/M2 ratio in the synovium. Only the SVF group showed partial expression of hNA-, CD163-, and F4/80-positive cells in the rat synovium. In vitro, the SVF, M2Φ, ADSC and control groups, in that order, showed larger pellet sizes, higher TGF-β and IL-10, and lower MMP-13 concentrations. Conclusions The M2Φ in the transplanted SVF directly affected recipient tissue, enhancing the secretion of growth factors and chondrocyte-protecting cytokines, and partially improving chondrocytes and joint homeostasis. These findings indicate that the SVF is as an effective option for regenerative therapy for OA, with mechanisms different from those of ADSCs. |
| ArticleNumber | 325 |
| Audience | Academic |
| Author | Hayashi, Shinya Maeda, Takuma Suda, Yoshihito Ikuta, Kemmei Matsumoto, Tomoyuki Nakano, Naoki Kuroda, Ryosuke Tachibana, Shotaro Wada, Kensuke Iwaguro, Hideki Saitoh, Akira Kuroda, Yuichi Hiranaka, Takafumi Kamenaga, Tomoyuki Onoi, Yuma Anjiki, Kensuke Tsubosaka, Masanori Matsushita, Takehiko Sobajima, Satoshi |
| Author_xml | – sequence: 1 givenname: Yuma surname: Onoi fullname: Onoi, Yuma organization: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan – sequence: 2 givenname: Tomoyuki orcidid: 0000-0003-4587-0029 surname: Matsumoto fullname: Matsumoto, Tomoyuki email: matsun@m4.dion.ne.jp organization: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan. matsun@m4.dion.ne.jp – sequence: 3 givenname: Kensuke surname: Anjiki fullname: Anjiki, Kensuke organization: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan – sequence: 4 givenname: Shinya surname: Hayashi fullname: Hayashi, Shinya organization: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan – sequence: 5 givenname: Naoki surname: Nakano fullname: Nakano, Naoki organization: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan – sequence: 6 givenname: Yuichi surname: Kuroda fullname: Kuroda, Yuichi organization: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan – sequence: 7 givenname: Masanori surname: Tsubosaka fullname: Tsubosaka, Masanori organization: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan – sequence: 8 givenname: Tomoyuki surname: Kamenaga fullname: Kamenaga, Tomoyuki organization: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan – sequence: 9 givenname: Kemmei surname: Ikuta fullname: Ikuta, Kemmei organization: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan – sequence: 10 givenname: Shotaro surname: Tachibana fullname: Tachibana, Shotaro organization: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan – sequence: 11 givenname: Yoshihito surname: Suda fullname: Suda, Yoshihito organization: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan – sequence: 12 givenname: Kensuke surname: Wada fullname: Wada, Kensuke organization: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan – sequence: 13 givenname: Takuma surname: Maeda fullname: Maeda, Takuma organization: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan – sequence: 14 givenname: Akira surname: Saitoh fullname: Saitoh, Akira organization: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan – sequence: 15 givenname: Takafumi surname: Hiranaka fullname: Hiranaka, Takafumi organization: Department of Orthopaedic Surgery and Joint Surgery Center, Takatsuki General Hospital, Osaka, Japan – sequence: 16 givenname: Satoshi surname: Sobajima fullname: Sobajima, Satoshi organization: Department of Orthopaedic Surgery, Sobajima Clinic, Osaka, Japan – sequence: 17 givenname: Hideki surname: Iwaguro fullname: Iwaguro, Hideki organization: Department of Orthopaedic Surgery, Sobajima Clinic, Osaka, Japan – sequence: 18 givenname: Takehiko surname: Matsushita fullname: Matsushita, Takehiko organization: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan – sequence: 19 givenname: Ryosuke surname: Kuroda fullname: Kuroda, Ryosuke organization: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39334434$$D View this record in MEDLINE/PubMed |
| BookMark | eNptkttu1DAQhiNURMvSF-ACWUJCcJHiUw57haoK6EpFSByurVl7snGV2MF2FngyXg9vt1S7Es6FE_ubXzN__qfFifMOi-I5oxeMtfXbyARvm5JyWVKxlHUpHhVnrKmasq4YPzl4Py3OY7yleQlBaS2fFKdiKYSUQp4Vf67nERyZnZ6HNAc0BIydfMTSYLDb_B1T8CMMZAsxMxBIF0An6x2Jvf8ZSeoxwIRzsppMPqFLNtOwAetiIj4m9BBSH2yykVhH7DjOzhvsrLYZJgFSJFsLxNiAOhHsurxF4juSArg4DeBS7uMTJyPo4KceNhifFY87GCKe3--L4vuH99-ursubzx9XV5c3pZaSibLRtYR1V9GmMig5sEZUAnlVdbDsGsiOcOQNRyFr2a45mraqQGveSo607RqxKFZ7XePhVk3BjhB-Kw9W3R34sFF5OqsHVEJgtQbDmOEoRdusZUtbzmvaGq6NMFnr3V5rmtcjGp2nDzAciR7fONurjd8qxrIe421WeH2vEPyPGWNSo40ah2wR-jkqwRhd0qatZEZf7tEN5N6s63yW1DtcXbaMSiobthvv4j9UfgyOVufEdTafHxW8OSrITMJfaQNzjGr19csx--qA7RGG1Ec_zLvwxGOQ78H8e2MM2D14wqjapV3t065y2tVd2rPZi-LFoZsPJf-yLf4C6Hj-zA |
| Cites_doi | 10.1016/j.biocel.2003.10.018 10.1016/j.biomaterials.2018.07.011 10.3390/cells10061365 10.3389/fimmu.2020.00111 10.4103/2277-9175.125799 10.1016/j.joca.2020.01.007 10.1002/jcb.25099 10.1186/s40064-015-1509-2 10.1016/j.ahj.2014.03.022 10.1186/ar2521 10.1016/j.reth.2019.07.010 10.1007/s11095-019-2634-3 10.1111/imr.12971 10.1016/j.cell.2011.08.039 10.1093/ndt/gfq603 10.1016/j.joca.2010.04.015 10.1016/j.joca.2014.05.009 10.1016/j.joca.2006.10.006 10.3390/ijms22062838 10.1016/j.reth.2023.06.006 10.1136/annrheumdis-2018-213450 10.1002/art.20506 10.1155/2014/561459 10.1016/j.reth.2017.04.002 10.3390/ijms18040774 10.3899/jrheum.140382 10.1002/jor.24958 10.1111/andr.12519 10.1016/j.jss.2013.05.024 10.1002/jcp.20228 10.1002/jcp.30823 10.1016/j.joca.2005.07.014 10.3390/ijms22083851 10.1016/j.bbamcr.2008.04.005 10.1002/jor.21394 10.1038/s41598-020-73096-y 10.1007/s12015-023-10589-z 10.5966/sctm.2014-0252 10.1016/j.scr.2011.06.003 10.1177/0363546517689871 10.1002/art.37908 10.1007/s00595-017-1544-4 10.3390/jcm10194309 10.1089/107632701300062859 10.1093/rheumatology/41.12.1413 10.1016/j.joca.2007.03.006 10.2337/db08-0872 10.1007/s00264-018-4099-0 10.4049/jimmunol.1500325 10.1016/j.pharmthera.2016.08.003 10.1002/jcb.23298 10.3390/ijms21228513 10.1186/s13287-021-02182-3 10.1186/s12891-020-03231-3 10.2147/JIR.S413578 10.1016/j.joca.2017.01.011 |
| ContentType | Journal Article |
| Copyright | 2024. The Author(s). COPYRIGHT 2024 BioMed Central Ltd. The Author(s) 2024 2024 |
| Copyright_xml | – notice: 2024. The Author(s). – notice: COPYRIGHT 2024 BioMed Central Ltd. – notice: The Author(s) 2024 2024 |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION ISR 7X8 5PM DOA |
| DOI | 10.1186/s13287-024-03946-3 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Gale In Context: Science MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1757-6512 |
| EndPage | 13 |
| ExternalDocumentID | oai_doaj_org_article_33e5bad11d2e4387b480822608d2cd3d A810404717 10_1186_s13287_024_03946_3 39334434 |
| Genre | Journal Article |
| GeographicLocations | Japan |
| GeographicLocations_xml | – name: Japan |
| GroupedDBID | --- -56 -5G -BR 0R~ 3V. 53G 5VS 7X7 88E 8FE 8FH 8FI 8FJ AAFWJ AAJSJ ABDBF ABUWG ACGFS ACIHN ACJQM ACPRK ACRMQ ADBBV ADINQ ADUKV AEAQA AENEX AFKRA AFPKN AHBYD AHMBA AHYZX ALIPV ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIAM AOIJS BAPOH BAWUL BBNVY BCNDV BENPR BFQNJ BHPHI BMC BPHCQ BVXVI C24 C6C CCPQU CGR CUY CVF DIK E3Z EBD EBLON EBS ECM EIF EMOBN ESX F5P FYUFA GROUPED_DOAJ GX1 HCIFZ HMCUK HYE IAO IEA IHR IHW INH INR ISR ITC KQ8 LK8 M1P M7P M~E NPM O5R O5S OK1 P2P PGMZT PIMPY PQQKQ PROAC PSQYO RBZ ROL RPM RSV SBL SOJ SV3 TUS UKHRP AAYXX CITATION 7X8 5PM |
| ID | FETCH-LOGICAL-c4413-7c64abf5075de42a17353e255fa9f7a0332e272e34648b2ed855acc2842e08f73 |
| IEDL.DBID | RPM |
| ISSN | 1757-6512 |
| IngestDate | Mon Sep 30 19:21:57 EDT 2024 Mon Sep 30 11:48:20 EDT 2024 Mon Sep 30 17:01:21 EDT 2024 Wed Oct 02 17:16:19 EDT 2024 Tue Oct 01 04:00:43 EDT 2024 Tue Oct 01 03:32:55 EDT 2024 Tue Oct 01 02:20:56 EDT 2024 Wed Oct 02 14:37:25 EDT 2024 Sun Oct 13 09:30:01 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | M2 macrophages Rat model Synovitis Adipose-derived stromal cells Xenotransplantation Stromal vascular fraction Osteoarthritis |
| Language | English |
| License | 2024. The Author(s). Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4413-7c64abf5075de42a17353e255fa9f7a0332e272e34648b2ed855acc2842e08f73 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-4587-0029 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438128/ |
| PMID | 39334434 |
| PQID | 3110907854 |
| PQPubID | 23479 |
| PageCount | 13 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_33e5bad11d2e4387b480822608d2cd3d pubmedcentral_primary_oai_pubmedcentral_nih_gov_11438128 proquest_miscellaneous_3110907854 gale_infotracmisc_A810404717 gale_infotracacademiconefile_A810404717 gale_incontextgauss_ISR_A810404717 gale_healthsolutions_A810404717 crossref_primary_10_1186_s13287_024_03946_3 pubmed_primary_39334434 |
| PublicationCentury | 2000 |
| PublicationDate | 20240927 |
| PublicationDateYYYYMMDD | 2024-09-27 |
| PublicationDate_xml | – month: 9 year: 2024 text: 20240927 day: 27 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: London |
| PublicationTitle | Stem cell research & therapy |
| PublicationTitleAlternate | Stem Cell Res Ther |
| PublicationYear | 2024 |
| Publisher | BioMed Central Ltd BioMed Central BMC |
| Publisher_xml | – name: BioMed Central Ltd – name: BioMed Central – name: BMC |
| References | S Zamani (3946_CR42) 2014; 3 K Anjiki (3946_CR30) 2023; 19 H Iijima (3946_CR34) 2014; 22 AW James (3946_CR56) 2017; 171 T Kamenaga (3946_CR52) 2021; 12 Y Sun (3946_CR46) 2020; 21 Y Wang (3946_CR20) 2001; 114 A Crowe (3946_CR40) 2019; 36 A van Dijk (3946_CR6) 2011; 7 HY Qureshi (3946_CR18) 2005; 203 L Utomo (3946_CR47) 2021; 39 JK Fraser (3946_CR7) 2004; 36 S Shi (3946_CR41) 2015; 116 Z Hong (3946_CR13) 2019; 43 S Ito (3946_CR10) 2017; 47 C Manferdini (3946_CR28) 2017; 25 F Iannone (3946_CR22) 2002; 41 T Katagiri (3946_CR11) 2020; 10 H Zhang (3946_CR45) 2018; 77 K O’Brien (3946_CR48) 2017; 18 EW Orlowsky (3946_CR54) 2015; 42 T Shirai (3946_CR43) 2011; 29 HY Qureshi (3946_CR19) 2008; 1783 B Rüger (3946_CR58) 2004; 50 PA Zuk (3946_CR2) 2001; 7 P Verma (3946_CR44) 2011; 112 G Marino (3946_CR8) 2013; 185 SS Glasson (3946_CR33) 2007; 15 M Fujita (3946_CR32) 2022; 237 I Sekiya (3946_CR53) 2021; 22 Y Onoi (3946_CR15) 2023; 24 N Agarwal (3946_CR1) 2021; 10 3946_CR17 P Luo (3946_CR55) 2023; 16 WL Parker (3946_CR23) 2007; 15 CN Lumeng (3946_CR25) 2008; 57 EC Perin (3946_CR9) 2014; 168 C Manferdini (3946_CR27) 2013; 65 Y Onoi (3946_CR31) 2019; 11 M Potente (3946_CR26) 2011; 146 I Mattiola (3946_CR39) 2015; 195 Z Feng (3946_CR3) 2010; 25 KPH Pritzker (3946_CR36) 2006; 14 R Schuster (3946_CR57) 2021; 302 M Hayashi (3946_CR35) 2008; 10 ME Morris (3946_CR24) 2015; 4 M Pomatto (3946_CR5) 2021; 22 N Yokota (3946_CR12) 2017; 6 M Dai (3946_CR50) 2018; 180 J Yamada (3946_CR38) 2014; 2014 M Tsubosaka (3946_CR14) 2020; 21 M Li (3946_CR4) 2018; 6 H Zhang (3946_CR49) 2020; 28 P Wojdasiewicz (3946_CR21) 2014; 2014 K Kamada (3946_CR29) 2021; 10 T Inokuchi (3946_CR51) 2017; 45 JA Aronowitz (3946_CR16) 2015; 4 VB Kraus (3946_CR37) 2010; 18 |
| References_xml | – volume: 36 start-page: 658 issue: 4 year: 2004 ident: 3946_CR7 publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2003.10.018 contributor: fullname: JK Fraser – volume: 180 start-page: 91 year: 2018 ident: 3946_CR50 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2018.07.011 contributor: fullname: M Dai – volume: 10 start-page: 1365 issue: 6 year: 2021 ident: 3946_CR1 publication-title: Cells doi: 10.3390/cells10061365 contributor: fullname: N Agarwal – ident: 3946_CR17 doi: 10.3389/fimmu.2020.00111 – volume: 3 start-page: 54 issue: 1 year: 2014 ident: 3946_CR42 publication-title: Adv Biomed Res doi: 10.4103/2277-9175.125799 contributor: fullname: S Zamani – volume: 28 start-page: 555 issue: 5 year: 2020 ident: 3946_CR49 publication-title: Osteoarthr Cartil doi: 10.1016/j.joca.2020.01.007 contributor: fullname: H Zhang – volume: 116 start-page: 1391 issue: 7 year: 2015 ident: 3946_CR41 publication-title: J Cell Biochem doi: 10.1002/jcb.25099 contributor: fullname: S Shi – volume: 4 start-page: 713 issue: 1 year: 2015 ident: 3946_CR16 publication-title: Springerplus doi: 10.1186/s40064-015-1509-2 contributor: fullname: JA Aronowitz – volume: 168 start-page: 88 issue: 1 year: 2014 ident: 3946_CR9 publication-title: Am Heart J doi: 10.1016/j.ahj.2014.03.022 contributor: fullname: EC Perin – volume: 10 start-page: R118 issue: 5 year: 2008 ident: 3946_CR35 publication-title: Arthritis Res Ther doi: 10.1186/ar2521 contributor: fullname: M Hayashi – volume: 11 start-page: 212 year: 2019 ident: 3946_CR31 publication-title: Regen Ther doi: 10.1016/j.reth.2019.07.010 contributor: fullname: Y Onoi – volume: 36 start-page: 101 issue: 7 year: 2019 ident: 3946_CR40 publication-title: Pharm Res doi: 10.1007/s11095-019-2634-3 contributor: fullname: A Crowe – volume: 302 start-page: 126 issue: 1 year: 2021 ident: 3946_CR57 publication-title: Immunol Rev doi: 10.1111/imr.12971 contributor: fullname: R Schuster – volume: 146 start-page: 873 issue: 6 year: 2011 ident: 3946_CR26 publication-title: Cell doi: 10.1016/j.cell.2011.08.039 contributor: fullname: M Potente – volume: 25 start-page: 3874 issue: 12 year: 2010 ident: 3946_CR3 publication-title: Nephrol Dial Transplant doi: 10.1093/ndt/gfq603 contributor: fullname: Z Feng – volume: 18 start-page: S35 year: 2010 ident: 3946_CR37 publication-title: Osteoarthr Cartil doi: 10.1016/j.joca.2010.04.015 contributor: fullname: VB Kraus – volume: 22 start-page: 1036 issue: 7 year: 2014 ident: 3946_CR34 publication-title: Osteoarthr Cartil doi: 10.1016/j.joca.2014.05.009 contributor: fullname: H Iijima – volume: 15 start-page: 442 issue: 4 year: 2007 ident: 3946_CR23 publication-title: Osteoarthr Cartil doi: 10.1016/j.joca.2006.10.006 contributor: fullname: WL Parker – volume: 22 start-page: 2838 issue: 6 year: 2021 ident: 3946_CR53 publication-title: Int J Mol Sci doi: 10.3390/ijms22062838 contributor: fullname: I Sekiya – volume: 24 start-page: 94 year: 2023 ident: 3946_CR15 publication-title: Regen Ther doi: 10.1016/j.reth.2023.06.006 contributor: fullname: Y Onoi – volume: 77 start-page: 1524 issue: 10 year: 2018 ident: 3946_CR45 publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2018-213450 contributor: fullname: H Zhang – volume: 50 start-page: 2157 issue: 7 year: 2004 ident: 3946_CR58 publication-title: Arthritis Rheum doi: 10.1002/art.20506 contributor: fullname: B Rüger – volume: 2014 start-page: 1 year: 2014 ident: 3946_CR21 publication-title: Mediat Inflamm doi: 10.1155/2014/561459 contributor: fullname: P Wojdasiewicz – volume: 6 start-page: 108 year: 2017 ident: 3946_CR12 publication-title: Regen Ther doi: 10.1016/j.reth.2017.04.002 contributor: fullname: N Yokota – volume: 18 start-page: 774 issue: 4 year: 2017 ident: 3946_CR48 publication-title: Int J Mol Sci doi: 10.3390/ijms18040774 contributor: fullname: K O’Brien – volume: 42 start-page: 363 issue: 3 year: 2015 ident: 3946_CR54 publication-title: J Rheumatol doi: 10.3899/jrheum.140382 contributor: fullname: EW Orlowsky – volume: 39 start-page: 2270 issue: 10 year: 2021 ident: 3946_CR47 publication-title: J Orthop Res doi: 10.1002/jor.24958 contributor: fullname: L Utomo – volume: 6 start-page: 927 issue: 6 year: 2018 ident: 3946_CR4 publication-title: Andrology doi: 10.1111/andr.12519 contributor: fullname: M Li – volume: 185 start-page: 36 issue: 1 year: 2013 ident: 3946_CR8 publication-title: J Surg Res doi: 10.1016/j.jss.2013.05.024 contributor: fullname: G Marino – volume: 203 start-page: 345 issue: 2 year: 2005 ident: 3946_CR18 publication-title: J Cell Physiol doi: 10.1002/jcp.20228 contributor: fullname: HY Qureshi – volume: 237 start-page: 3627 issue: 9 year: 2022 ident: 3946_CR32 publication-title: J Cell Physiol doi: 10.1002/jcp.30823 contributor: fullname: M Fujita – volume: 14 start-page: 13 issue: 1 year: 2006 ident: 3946_CR36 publication-title: Osteoarthr Cartil doi: 10.1016/j.joca.2005.07.014 contributor: fullname: KPH Pritzker – volume: 22 start-page: 3851 issue: 8 year: 2021 ident: 3946_CR5 publication-title: Int J Mol Sci doi: 10.3390/ijms22083851 contributor: fullname: M Pomatto – volume: 1783 start-page: 1605 issue: 9 year: 2008 ident: 3946_CR19 publication-title: Biochim Biophys Acta (BBA) Mol Cell Res doi: 10.1016/j.bbamcr.2008.04.005 contributor: fullname: HY Qureshi – volume: 29 start-page: 1572 issue: 10 year: 2011 ident: 3946_CR43 publication-title: J Orthop Res doi: 10.1002/jor.21394 contributor: fullname: T Shirai – volume: 2014 start-page: 1 year: 2014 ident: 3946_CR38 publication-title: Int J Inflamm contributor: fullname: J Yamada – volume: 10 start-page: 16045 issue: 1 year: 2020 ident: 3946_CR11 publication-title: Sci Rep doi: 10.1038/s41598-020-73096-y contributor: fullname: T Katagiri – volume: 19 start-page: 2407 issue: 7 year: 2023 ident: 3946_CR30 publication-title: Stem Cell Rev Rep doi: 10.1007/s12015-023-10589-z contributor: fullname: K Anjiki – volume: 4 start-page: 369 issue: 4 year: 2015 ident: 3946_CR24 publication-title: Stem Cells Transl Med doi: 10.5966/sctm.2014-0252 contributor: fullname: ME Morris – volume: 7 start-page: 219 issue: 3 year: 2011 ident: 3946_CR6 publication-title: Stem Cell Res doi: 10.1016/j.scr.2011.06.003 contributor: fullname: A van Dijk – volume: 45 start-page: 1359 issue: 6 year: 2017 ident: 3946_CR51 publication-title: Am J Sports Med doi: 10.1177/0363546517689871 contributor: fullname: T Inokuchi – volume: 65 start-page: 1271 issue: 5 year: 2013 ident: 3946_CR27 publication-title: Arthritis Rheum doi: 10.1002/art.37908 contributor: fullname: C Manferdini – volume: 47 start-page: 1500 issue: 12 year: 2017 ident: 3946_CR10 publication-title: Surg Today doi: 10.1007/s00595-017-1544-4 contributor: fullname: S Ito – volume: 10 start-page: 4309 issue: 19 year: 2021 ident: 3946_CR29 publication-title: J Clin Med doi: 10.3390/jcm10194309 contributor: fullname: K Kamada – volume: 7 start-page: 211 issue: 2 year: 2001 ident: 3946_CR2 publication-title: Tissue Eng doi: 10.1089/107632701300062859 contributor: fullname: PA Zuk – volume: 41 start-page: 1413 issue: 12 year: 2002 ident: 3946_CR22 publication-title: Rheumatology doi: 10.1093/rheumatology/41.12.1413 contributor: fullname: F Iannone – volume: 15 start-page: 1061 issue: 9 year: 2007 ident: 3946_CR33 publication-title: Osteoarthr Cartil doi: 10.1016/j.joca.2007.03.006 contributor: fullname: SS Glasson – volume: 57 start-page: 3239 issue: 12 year: 2008 ident: 3946_CR25 publication-title: Diabetes doi: 10.2337/db08-0872 contributor: fullname: CN Lumeng – volume: 43 start-page: 1123 issue: 5 year: 2019 ident: 3946_CR13 publication-title: Int Orthop doi: 10.1007/s00264-018-4099-0 contributor: fullname: Z Hong – volume: 195 start-page: 2818 issue: 6 year: 2015 ident: 3946_CR39 publication-title: J Immunol doi: 10.4049/jimmunol.1500325 contributor: fullname: I Mattiola – volume: 171 start-page: 93 year: 2017 ident: 3946_CR56 publication-title: Pharmacol Ther doi: 10.1016/j.pharmthera.2016.08.003 contributor: fullname: AW James – volume: 112 start-page: 3507 issue: 12 year: 2011 ident: 3946_CR44 publication-title: J Cell Biochem doi: 10.1002/jcb.23298 contributor: fullname: P Verma – volume: 21 start-page: 8513 issue: 22 year: 2020 ident: 3946_CR46 publication-title: Int J Mol Sci doi: 10.3390/ijms21228513 contributor: fullname: Y Sun – volume: 12 start-page: 110 issue: 1 year: 2021 ident: 3946_CR52 publication-title: Stem Cell Res Ther doi: 10.1186/s13287-021-02182-3 contributor: fullname: T Kamenaga – volume: 21 start-page: 207 issue: 1 year: 2020 ident: 3946_CR14 publication-title: BMC Musculoskelet Disord doi: 10.1186/s12891-020-03231-3 contributor: fullname: M Tsubosaka – volume: 16 start-page: 2329 year: 2023 ident: 3946_CR55 publication-title: J Inflamm Res doi: 10.2147/JIR.S413578 contributor: fullname: P Luo – volume: 114 start-page: 723 issue: 7 year: 2001 ident: 3946_CR20 publication-title: Chin Med J (Engl) contributor: fullname: Y Wang – volume: 25 start-page: 1161 issue: 7 year: 2017 ident: 3946_CR28 publication-title: Osteoarthr Cartil doi: 10.1016/j.joca.2017.01.011 contributor: fullname: C Manferdini |
| SSID | ssj0000330064 |
| Score | 2.406244 |
| Snippet | The uncultured adipose-derived stromal vascular fraction (SVF), consisting of adipose-derived stromal cells (ADSCs), M2 macrophages (M2Φ) and others, has shown... Background The uncultured adipose-derived stromal vascular fraction (SVF), consisting of adipose-derived stromal cells (ADSCs), M2 macrophages (M2Φ) and... The uncultured adipose-derived stromal vascular fraction (SVF), consisting of adipose-derived stromal cells (ADSCs), M2 macrophages (M2Φ) and others, has... Abstract Background The uncultured adipose-derived stromal vascular fraction (SVF), consisting of adipose-derived stromal cells (ADSCs), M2 macrophages (M2Φ)... |
| SourceID | doaj pubmedcentral proquest gale crossref pubmed |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database |
| StartPage | 325 |
| SubjectTerms | Adipose Tissue - cytology Adipose-derived stromal cells Animals Chondrocytes - cytology Chondrocytes - metabolism Collagen Disease Models, Animal Enzyme-linked immunosorbent assay Enzymes Ethylenediaminetetraacetic acid Female Health aspects Humans M2 macrophages Macrophages Macrophages - metabolism Osteoarthritis Osteoarthritis - pathology Osteoarthritis - therapy Phosphates Rats Stromal vascular fraction Stromal Vascular Fraction - metabolism Synovitis Transforming growth factors Xenotransplantation |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Pi9UwEA6yIHgRf1tdNYrgQcq2SZqmx1VcVmE9qAt7C0mT7ivsNo-XvhX_Mv89J0nfo8WDF49thtLOTOabKTNfEHpr6tpAmNN5F0dyGs1yHYZ9VMmN5sJYY0OhePaVn56zLxfVxeyor9ATluiBk-KOKLWVVqYsDbGMilozEUjKeSEMaQ01MfqW1ayYijEYynQA292UjOBHHsou2E8ASXlBG8ZzukCiSNj_d1ie4dKyZ3IGQif30N0pe8TH6a3vo1t2eIBup_Mkfz1Ev-MveQxQFfk0rMHK9GvnbW7A0W7g2o8bdw1P2DWg4m6TJhuwX7mfHs_GsfDajaGVCKTVpeohjcRhIMSBylaRCQn3A-7DeIkzNvBQgDAGf_L4plc4QSWe2kWw6_AYadSvgiUNPiP4WoXTw1YQz_wjdH7y6cfH03w6mSFvIX2ied1ypnQHuWRlLCOqrGlFLVQnnWq6WoH2iSU1sZRxJjSxRlSValuAQmIL0dX0MToY3GCfIgzGKCwgJmSunFVwZRrW6oJppRlttcjQ-52V5DoRcMhYuAguk00l2FRGm0qaoQ_BkHvJQJ4db4BLycml5L9cKkOvghvINIm6DwHyWEDtWgCa1xl6EyUCgcYQOnQu1dZ7-fn7t4XQu0moc6DiVk0DD_DdgXNrIXm4kIQd3i6WX-_8UYal0BY3WLf1kga-WEjyKpahJ8k_959OG0oZo7AiFp670M1yZehXkWAcamRI5Ih49j-0-RzdIXHXNTmpD9HBuNnaF5DIjfpl3LN_ABl8SG4 priority: 102 providerName: Directory of Open Access Journals |
| Title | Human uncultured adipose-derived stromal vascular fraction shows therapeutic potential against osteoarthritis in immunodeficient rats via direct effects of transplanted M2 macrophages |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/39334434 https://www.proquest.com/docview/3110907854/abstract/ https://pubmed.ncbi.nlm.nih.gov/PMC11438128 https://doaj.org/article/33e5bad11d2e4387b480822608d2cd3d |
| Volume | 15 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9swFBZtx2AvY_d56zJtDPYw3DiSbCmPTWnpBiklW6HsRejmxNDYIU469sv293Yk2yFmb3sJODoJts7lO8ec8wmhT5ZzC2FOx3kYyRlrFms_7KNGmdWZsM46XyhOr7LLG_btNr09QFk3CxOa9o0uTsq75UlZLEJv5Wpphl2f2PB6ejbyZ3ZDYB0eokNO6V6NHuIvlOgAtN2EjMiGNZRc4EsAR3FCxyyL_ek5FEp5xijrAVLg7f83Ou_BU791cg-LLp6gx20SiU-bm32KDlz5DD1sjpX8_Rz9CW_mMSBWoNVwFitbrKraxRbs7R6u6826WsI_dH2oOF83Aw64XlS_arw3lYVX1cZ3FIG0mqsCskns50Iq2KlFIETCRYkLP2VSWefpKEAYg1nV-L5QuEFM3HaN4CrHm8CmfucVavGU4KXyh4gtIKzVL9DNxfmPs8u4PaAhNpBF0ZibjCmdQ0qZWseIGnGaUgdFSq7GOVegCOIIJ46yjAlNnBVpqowBRCQuETmnL9FRWZXuNcKgl8QBcEICm7EUruyYGZ0wrTSjRosIfem0JFcND4cM9YvIZKNeCeqVQb2SRmjiFbmT9Bza4YtqPZetJUlKXaqVHY0scWBPXDPh6e-zRFhiLLUReu_NQDYDqbtIIE8FlLAJgDqP0Mcg4Xk0St-oM1fbupZfv896Qp9bobyCLTaqnXuA5_bUWz3J454kOLrpLX_o7FH6Jd8dV7pqW0vqaWMh10tZhF419rl79M7MIyR6ltvbm_4KuF3gGe_c7M3___QtekSC241jwo_R0Wa9de8gi9voAbjuLR-gB5Pzq-vZILwLgc_Z5OcguPNfMnVOJQ |
| link.rule.ids | 230,315,733,786,790,870,891,2115,27955,27956,31753,33778,53825,53827 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbGEIIX7pfAYAYh8YDSprbjpI9jYupgnRBsYm-Wb2kj1qRq0iH4Y_w9jp2kauAJHhOfVHXOd27ROZ8Rem2SxICbU2HmR3LGioXKDfvIETeKp8Ya6wrF6SmfnLMPF_HFDuLdLIxv2tcqHxSXi0GRz31v5XKhh12f2PDT9HDkzuwGxzq8hq6DwZJ4q0r3HhiKdAi13YxMyocVFF1gTRCQwoiOGQ_d-TkUinnGKOuFJM_c_7d_3gpQ_ebJrWh0dAd97fbRNKF8G6xrNdA__6B4_PeN3kW32wQVHzTr99COLe6jG82RlT8eoF_-qz-GaOgpO6zB0uTLsrKhASxfwXVVr8oF_ELX44qzVTM8gat5-b3CWxNfeFnWrlsJpOVM5pCpYjdzUsKfm3uyJZwXOHcTLKWxjuoChDFAtsJXucRNNMZtRwouM1x7pvZLBxaDpwQvpDugbA4us3qIzo_enx1Owvbwh1BDhkbDRHMmVQbpamwsI3KU0JhaKIAyOc4SCSomliTEUsZZqog1aRxLrSHaEhulWUIfod2iLOwThEHjkYWgDMkxZzFcmTHTKmJKKka1SgP0ttO_WDYcH8LXRikXDXAEAEd44AgaoHcOIhtJx8_tb5SrmWiVJyi1sZJmNDLEggoTxVJHrc-j1BBtqAnQvgOYaIZdN15GHKRQHkeQMCQBeuUlHEdH4ZqAZnJdVeL4y-ee0JtWKCvhFWvZzlTAvh2tV09yrycJTkT3ll92SBduyXXeFbZcV4I6SlrII2MWoMcN8jdb7wwoQGnPJnrvpr8CSPcc5h2yn_7_o_vo5uRseiJOjk8_PkO3iDfucUiSPbRbr9b2OWSLtXrhXcNv3Ddrww |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLZgCMQL90tgMIOQeEBpU9tJ3McxqDag0wRMmrQHy7e0EWtSNekQ_DH-HsdOUjXwtsfEJ1Udfz6X6DufEXpj0tSAm1Nh5ltyxoqFyjX7yFFiVMKNNdYVitPj5PCUfTqLz1pWZdXSKgut8kFxsRgU-dxzK5cLPex4YsOT6cHIndkNjnW4NNnwOroBm5akW5W698JQqEO47fpkeDKsoPCCHQVBKYzomCWhO0OHQkHPGGW9sOTV-__30VtBqk-g3IpIk7vovJtLQ0T5MVjXaqB__yPzeLXJ3kN32kQV7zc299E1WzxAN5ujK389RH_8138MUdFLd1iDpcmXZWVDA5i-hOuqXpUL-IWO64qzVdNEgat5-bPCW51feFnWjrUE1nImc8hYses9KeEPzr3oEs4LnLtOltJYJ3kBxhigW-HLXOImKuOWmYLLDNdesf3CgcbgKcEL6Q4qm4PrrB6h08nH7weHYXsIRKghU6NhqhMmVQZpa2wsI3KU0phaKIQyOc5SCctMLEmJpSxhXBFreBxLrSHqEhvxLKWP0U5RFvYpwrDqkYXgDElywmK4MmOmVcSUVIxqxQP0rsOAWDZaH8LXSDwRDXgEgEd48AgaoPcOJhtLp9Ptb5SrmWgXUFBqYyXNaGSIhWVMFeNOYj-JuCHaUBOgPQcy0TS9bryN2OdQJkeQOKQBeu0tnFZH4chAM7muKnH07WvP6G1rlJXwirVseytg3k7eq2e527MEZ6J7w686tAs35Bh4hS3XlaBOmhbyyZgF6EmD_s3Uu00UIN7bF7130x8BtHst8w7dz67-6B66dfJhIr4cHX9-jm4Tv7_HIUl30U69WtsXkDTW6qX3Dn8BBkhuQw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Human+uncultured+adipose-derived+stromal+vascular+fraction+shows+therapeutic+potential+against+osteoarthritis+in+immunodeficient+rats+via+direct+effects+of+transplanted+M2+macrophages&rft.jtitle=Stem+cell+research+%26+therapy&rft.au=Onoi%2C+Yuma&rft.au=Matsumoto%2C+Tomoyuki&rft.au=Anjiki%2C+Kensuke&rft.au=Hayashi%2C+Shinya&rft.date=2024-09-27&rft.pub=BioMed+Central+Ltd&rft.issn=1757-6512&rft.eissn=1757-6512&rft.volume=15&rft.issue=1&rft_id=info:doi/10.1186%2Fs13287-024-03946-3&rft.externalDocID=A810404717 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1757-6512&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1757-6512&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1757-6512&client=summon |