Human IL-2Rɑ subunit binding modulation of IL-2 through a decline in electrostatic interactions: A computational and experimental approach - Beig Parikhani, Arezoo; Bagherzadeh, Kowsar; Dehghan, Rada; Biglari, Alireza; Shokrgozar, Mohammad Ali; Riazi Rad, Farhad; Zeinali, Sirous; Talebkhan, Yeganeh; Ajdary, Soheila; Ahangari Cohan, Reza; Behdani, Mahdi (PloS one, 2022)
Keywords: Affinity; Anticancer properties; Antitumor activity; Binding; Biology and Life Sciences; Biotechnology; CD25 antigen; Chemical compounds; Computer applications; Cytokines; Cytotoxicity; Drug dosages; Electrostatic properties; Flow cytometry; Humans; Hypotension; Immunology; Immunotherapy; Interleukin 2; Interleukin 2 receptors; Interleukin-2 - chemistry; Interleukin-2 - metabolism; Interleukin-2 Receptor alpha Subunit - chemistry; Interleukin-2 Receptor alpha Subunit - metabolism; Kidney cancer; Laboratories; Leukocytes, Mononuclear - metabolism; Lymphocytes; Medicine and Health Sciences; Metastasis; Molecular Docking Simulation; Molecular dynamics; Molecular Dynamics Simulation; Monoclonal antibodies; Mutants; Peripheral blood mononuclear cells; Pharmacology; Physical Sciences; Protein Binding; Research and Analysis Methods; Sampling techniques; Side effects; Simulation; Static Electricity; Toxicity; Tumor necrosis factor-TNF; Vascular leak syndrome; Iran