Chronic Lead Exposure and Mixed Factors of Gender×Age×Brain Regions Interactions on Dendrite Growth, Spine Maturity and NDR Kinase

• Published in: PloS one Vol. 10; no. 9; p. e0138112
• Main Authors: Du, Yang, Ge, Meng-Meng, Xue, Weizhen, Yang, Qian-Qian, Wang, Shuang, Xu, Yi, Wang, Hui-Li
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.09.2015; Public Library of Science (PLoS)
• Subjects: Adolescents; Age; Aging - drug effects; Aging - metabolism; Aging - pathology; Animal cognition; Animals; Biotechnology; Brain; Brain damage; Brain research; Calcium; Calcium channels; Calcium channels (L-type); Calcium ions; Calcium Signaling - drug effects; Cognitive ability; Dendrites; Dendrites - metabolism; Dendrites - pathology; Dendritic spines; Dendritic structure; Engineering; Exposure; Female; Fluorescence; Food; Gender differences; Gene expression; Hippocampus; Hippocampus - metabolism; Hippocampus - pathology; Impairment; Laboratory animals; Lead; Lead - toxicity; Male; Maturity; Memory; mRNA; Neurosciences; Neurotoxicity; Parturition; PCB; Polychlorinated biphenyls; Prefrontal cortex; Prefrontal Cortex - metabolism; Prefrontal Cortex - pathology; Protein-Serine-Threonine Kinases - metabolism; Rats; Rats, Sprague-Dawley; Rodents; Sex Characteristics; Signal transduction; Spine; Spine - metabolism; Spine - pathology; Studies; Substrates; China

NDR1/2 kinase is essential in dendrite morphology and spine formation, which is regulated by cellular Ca2+. Lead (Pb) is a potent blocker of L-type calcium channel and our recent work showed Pb exposure impairs dendritic spine outgrowth in hippocampal neurons in rats. But the sensitivity of Pb-induc...