Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury

• Published in: PloS one Vol. 14; no. 10; p. e0223180
• Main Authors: Titus, David J., Johnstone, Timothy, Johnson, Nathan H., London, Sidney H., Chapalamadugu, Meghana, Hogenkamp, Derk, Gee, Kelvin W., Atkins, Coleen M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.10.2019; Public Library of Science (PLoS)
• Subjects: Acetylcholine receptors (nicotinic); Allosteric properties; Allosteric Regulation - drug effects; alpha7 Nicotinic Acetylcholine Receptor - metabolism; Alzheimer's disease; Anilides - blood; Anilides - pharmacokinetics; Anilides - pharmacology; Anilides - therapeutic use; Animal cognition; Animals; Atrophy; Biology and Life Sciences; Brain; Brain - drug effects; Brain - metabolism; Brain - pathology; Brain Injuries, Traumatic - complications; Brain slice preparation; Cholinergic transmission; Cholinergics; Chronic Disease; Cognition; Cognition Disorders - drug therapy; Cognition Disorders - etiology; Cognition Disorders - physiopathology; Cognitive ability; Conditioning (learning); Conditioning, Classical; Cortex; Fear; Fear conditioning; Head injuries; Hippocampal plasticity; Hippocampus; Isoxazoles - blood; Isoxazoles - pharmacokinetics; Isoxazoles - pharmacology; Isoxazoles - therapeutic use; Laboratory animals; Learning; Long-term potentiation; Long-Term Potentiation - drug effects; Male; Maze Learning; Medicine; Medicine and Health Sciences; Memory; Memory, Short-Term; Mental disorders; Modulation; Neurosciences; Percussion; Pharmacology; Rats, Sprague-Dawley; Recovery; Schizophrenia; Short term memory; Social Sciences; Surgery; Synaptic plasticity; Synaptic transmission; Synaptic Transmission - drug effects; Trauma; Traumatic brain injury; Water treatment; Florida; United States > US; California

Cognitive impairments are a common consequence of traumatic brain injury (TBI). The hippocampus is a subcortical structure that plays a key role in the formation of declarative memories and is highly vulnerable to TBI. The α7 nicotinic acetylcholine receptor (nAChR) is highly expressed in the hippoc...