Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury - Titus, David J.; Johnstone, Timothy; Johnson, Nathan H.; London, Sidney H.; Chapalamadugu, Meghana; Hogenkamp, Derk; Gee, Kelvin W.; Atkins, Coleen M. (PloS one, 2019)
Keywords: Acetylcholine receptors (nicotinic); Allosteric properties; Allosteric Regulation - drug effects; alpha7 Nicotinic Acetylcholine Receptor - metabolism; Alzheimer's disease; Anilides - blood; Anilides - pharmacokinetics; Anilides - pharmacology; Anilides - therapeutic use; Animal cognition; Animals; Atrophy; Biology and Life Sciences; Brain; Brain - drug effects; Brain - metabolism; Brain - pathology; Brain Injuries, Traumatic - complications; Brain slice preparation; Cholinergic transmission; Cholinergics; Chronic Disease; Cognition; Cognition Disorders - drug therapy; Cognition Disorders - etiology; Cognition Disorders - physiopathology; Cognitive ability; Conditioning (learning); Conditioning, Classical; Cortex; Fear; Fear conditioning; Head injuries; Hippocampal plasticity; Hippocampus; Isoxazoles - blood; Isoxazoles - pharmacokinetics; Isoxazoles - pharmacology; Isoxazoles - therapeutic use; Laboratory animals; Learning; Long-term potentiation; Long-Term Potentiation - drug effects; Male; Maze Learning; Medicine; Medicine and Health Sciences; Memory; Memory, Short-Term; Mental disorders; Modulation; Neurosciences; Percussion; Pharmacology; Rats, Sprague-Dawley; Recovery; Schizophrenia; Short term memory; Social Sciences; Surgery; Synaptic plasticity; Synaptic transmission; Synaptic Transmission - drug effects; Trauma; Traumatic brain injury; Water treatment; Florida; United States--US; California