Enhanced resting‐state dynamics of the hemoglobin signal as a novel biomarker for detection of breast cancer

• Published in: Medical physics (Lancaster) Vol. 42; no. 11; pp. 6406 - 6424
• Main Authors: Graber, Harry L., Al abdi, Rabah, Xu, Yong, Asarian, Armand P., Pappas, Peter J., Dresner, Lisa, Patel, Naresh, Jagarlamundi, Kuppuswamy, Solomon, William B., Barbour, Randall L.
• Format: Journal Article
• Language: English
• Published: United States American Association of Physicists in Medicine 01.11.2015
• Subjects: 60 APPLIED LIFE SCIENCES; AMPLITUDES; ANIMAL TISSUES; biochemistry; Biochemistry; Beer; Spirits; Wine; Vinegar; Microbiology; Enzymology; Mutation or genetic engineering; biodiffusion; BIOLOGICAL MARKERS; Biological material, e.g. blood, urine; Haemocytometers; biological organs; biological signal processing; Biomarkers - analysis; biomedical optical imaging; BIOMEDICAL RADIOGRAPHY; Breast Neoplasms - chemistry; Breast Neoplasms - complications; Breast Neoplasms - diagnosis; cancer; DIAGNOSIS; Digital computing or data processing equipment or methods, specially adapted for specific applications; Female; HEMOGLOBIN; Hemoglobins - analysis; Humans; Image data processing or generation, in general; Image Interpretation, Computer-Assisted - methods; image processing in medical imaging; Image sensors; MAMMARY GLANDS; mammography; medical image processing; Medical imaging; Middle Aged; modeling of biomedical systems; molecular biophysics; Molecular Imaging - methods; NEOPLASMS; Neovascularization, Pathologic - complications; Neovascularization, Pathologic - diagnosis; Neovascularization, Pathologic - metabolism; Optical microscopy; Optical Physics; optical tomography; PATHOLOGY; Probability theory, stochastic processes, and statistics; proteins; Reproducibility of Results; Sensitivity and Specificity; Spatial dimensions; Spatial scaling; Statistical analysis; Time measurement; time series; Time series analysis; Tissues; Tomography, Optical - methods; tumours

Purpose: The work presented here demonstrates an application of diffuse optical tomography (DOT) to the problem of breast‐cancer diagnosis. The potential for using spatial and temporal variability measures of the hemoglobin signal to identify useful biomarkers was studied. Methods: DOT imaging data...