Copper deficiency-induced anemia is caused by a mitochondrial metabolic reprograming in erythropoietic cells

• Published in: Metallomics Vol. 11; no. 2; p. 282
• Main Authors: Jensen, Erik L, Gonzalez-Ibanez, Alvaro M, Mendoza, Pierina, Ruiz, Lina M, Riedel, Claudia A, Simon, Felipe, Schuringa, Jan J, Elorza, Alvaro A
• Format: Journal Article
• Language: English
• Published: England 20.02.2019
• Subjects: Animals; Blotting, Western; Cell Proliferation - genetics; Cell Proliferation - physiology; Cells, Cultured; Copper - metabolism; Erythropoiesis - genetics; Erythropoiesis - physiology; Flow Cytometry; Humans; Leukocytes, Mononuclear - metabolism; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Mitochondria - metabolism; Mitochondrial Proteins - metabolism

The lack of copper has been associated with anemia, myelodysplastic syndromes and leukemia as well as with a loss in complex IV activity and an enlarged mitochondrial morphology. Mitochondria play a key role during the differentiation of hematopoietic stem cells by regulating the passage from a glyc...