Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial

• Published in: Clinical nutrition (Edinburgh, Scotland) Vol. 38; no. 2; pp. 522 - 528
• Main Authors: Kazemi, Asma, Noorbala, Ahmad Ali, Azam, Kamal, Eskandari, Mohammad Hadi, Djafarian, Kurosh
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2019
• Subjects: Adult; Bifidobacterium longum; blood serum; branched chain amino acids; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - psychology; digestive system; Double-Blind Method; enzyme-linked immunosorbent assay; Female; food intake; galactooligosaccharides; high performance liquid chromatography; Humans; intestinal microorganisms; inventories; isoleucine; kynurenine; Lactobacillus helveticus; Major depressive disorders; Male; MDD; mental depression; pathophysiology; patients; physical activity; placebos; Prebiotic; prebiotics; Prebiotics - administration & dosage; Probiotic; probiotics; Probiotics - administration & dosage; Probiotics - therapeutic use; Psychological outcomes; randomized clinical trials; Treatment Outcome; tryptophan; Probiotic; PP; Psychological outcomes; RCT; BDI; ITT; MDD; BCAAs; IPAQ; Prebiotic; MET; Major depressive disorders; BMI

Disturbance in the equilibrium of the gut microbiota has been involved in the pathophysiology of depression. Probiotics have the potential to healthfully modulate the gut microbiome. Prebiotics could also be effective by stimulation of growth of some bacterial species in the gut microbiota. The aim...