Breadth of humoral immune responses to the C-terminus of the circumsporozoite protein is associated with protective efficacy induced by the RTS,S malaria vaccine

• Published in: Vaccine Vol. 39; no. 6; pp. 968 - 975
• Main Authors: Chaudhury, Sidhartha, MacGill, Randall S., Early, Angela M., Bolton, Jessica S., King, C. Richter, Locke, Emily, Pierson, Tony, Wirth, Dyann F., Neafsey, Daniel E., Bergmann-Leitner, Elke S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 05.02.2021; Elsevier Limited
• Subjects: Adaptive immunity; Alleles; Antibodies; Antibodies, Protozoan; Antigenic variation; Antigens; Avidity; C-Terminus; Circumsporozoite protein; Clinical trials; Genetic diversity; Human subjects; Humans; Immune response (humoral); Immunity, Humoral; Malaria; Malaria Vaccines - immunology; Malaria, Falciparum - prevention & control; Parasites; Peptides; Plasmodium falciparum; Polymorphism; Protection; Proteins; Protozoan Proteins - immunology; Reactivity; Reduction; Serology; Sporozoites; Vaccine; Vaccines; Vector-borne diseases; Th_R; CSP; Malaria; Serology; Vaccine; ECLIA; AS; RTS,S; TSR; MLS; Protection; NK; Circumsporozoite protein; CHMI; Polymorphism; MSD

•Development of novel multiplex assay to test antigen variants without antigenic competition.•Malaria circumsporozoite protein variants identified in field studies for vaccine evaluation.•Breadth of antibody reactivity to vaccine variant antigens predicts protection from infection.•Data point to cri...