Electromechanical window negativity in genotyped long-QT syndrome patients: relation to arrhythmia risk

• Published in: European heart journal Vol. 36; no. 3; pp. 179 - 186
• Main Authors: ter Bekke, Rachel M.A., Haugaa, Kristina H., van den Wijngaard, Arthur, Bos, J. Martijn, Ackerman, Michael J., Edvardsen, Thor, Volders, Paul G.A.
• Format: Journal Article
• Language: English
• Published: England 14.01.2015
• Subjects: Adrenergic beta-Antagonists - therapeutic use; Adult; Analysis of Variance; Anti-Arrhythmia Agents - therapeutic use; Arrhythmias, Cardiac - genetics; Case-Control Studies; Death, Sudden, Cardiac - prevention & control; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels - genetics; Female; Genotype; Heterozygote; Humans; Ion Channels - genetics; Ion Channels - physiology; KCNQ1 Potassium Channel - genetics; Long QT Syndrome - drug therapy; Long QT Syndrome - genetics; Long QT Syndrome - physiopathology; Male; Mutation - genetics; NAV1.5 Voltage-Gated Sodium Channel - genetics; Potassium Channels, Voltage-Gated - genetics; Risk Factors; Ultrasonography, Doppler; Ion channels; Long-QT syndrome; Echocardiography; Arrhythmia; Sudden death

Prolonged and dispersed left-ventricular (LV) contraction is present in patients with long-QT syndrome (LQTS). Electrical and mechanical abnormalities appear most pronounced in symptomatic individuals. We focus on the 'electromechanical window' (EMW; duration of LV-mechanical systole minus...