Association of Helicobacter pylori Vacuolating Toxin (VacA) with Lipid Rafts

• Published in: The Journal of biological chemistry Vol. 277; no. 37; pp. 34642 - 34650
• Main Authors: Schraw, Wayne, Li, Yi, McClain, Mark S., van der Goot, F. Gisou, Cover, Timothy L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.09.2002; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Bacterial Proteins - metabolism; Bacterial Proteins - toxicity; beta-Cyclodextrins; Cell Membrane - drug effects; CHO Cells; Cricetinae; Cyclodextrins - pharmacology; Glycosylphosphatidylinositols - physiology; HeLa Cells; Humans; Membrane Microdomains - metabolism; Nystatin - pharmacology; Vacuoles - drug effects

A variety of extracellular ligands and pathogens interact with raft domains in the plasma membrane of eukaryotic cells. In this study, we examined the role of lipid rafts and raft-associated glycosylphosphatidylinositol (GPI)-anchored proteins in the process by which Helicobacter pylorivacuolating t...