Glucose metabolism in photoreceptor outer segments. Its role in phototransduction and in NADPH-requiring reactions

• Published in: The Journal of biological chemistry Vol. 269; no. 27; pp. 17954 - 17959
• Main Authors: Hsu, S C, Molday, R S
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Biochemistry and Molecular Biology 08.07.1994
• Subjects: Adenosine Triphosphate - biosynthesis; Anaerobiosis; Animals; Biological and medical sciences; Cattle; Cell metabolism, cell oxidation; Cell physiology; Fundamental and applied biological sciences. Psychology; Glucose - metabolism; Glutathione Reductase - metabolism; Glycolysis; Guanosine Triphosphate - biosynthesis; Light; Molecular and cellular biology; NADP - metabolism; Oxidation-Reduction; Rod Cell Outer Segment - metabolism; Signal Transduction; Vision, photoreception; NADPH; Photoreception; Bovine; Rod; Glucose; Signal transduction; Vertebrata; Mammalia; Glycolysis; Artiodactyla; ATP; Retinal; Ungulata

Glucose metabolism in the photoreceptor rod outer segment produces both ATP (GTP) and NADPH to support phototransduction and NADPH-requiring processes in this organelle. Glycolysis in isolated bovine rod outer segments produces 44.0 +/- 6.4 nmol of ATP/min/mg of protein or 5.7 mM ATP/min. This rate...