β-elemene enhances the radiosensitivity of gastric cancer cells by inhibiting Pak1 activation

• Published in: World journal of gastroenterology : WJG Vol. 21; no. 34; pp. 9945 - 9956
• Main Author: Liu, Jun-Song
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 14.09.2015
• Subjects: Apoptosis - drug effects; Apoptosis - radiation effects; Basic Study; cancer; Cell Line, Tumor; Cell Survival - drug effects; Cell Survival - radiation effects; cells;Cl; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases - metabolism; Humans; Intracellular Signaling Peptides and Proteins - metabolism; p21-Activated Kinases - antagonists & inhibitors; p21-Activated Kinases - metabolism; Phosphorylation; Protein Kinase Inhibitors - pharmacology; Proteomics - methods; Radiation Tolerance - drug effects; Radiation-Sensitizing Agents - pharmacology; Sesquiterpenes - pharmacology; Signal Transduction - drug effects; Stomach Neoplasms - enzymology; Stomach Neoplasms - pathology; Stomach Neoplasms - radiotherapy; Time Factors; β-elemene;Radiosensitivity;Gastric; β-elemene; p21-activated protein kinase 1; Clonogenic survival; Radiosensitivity; Gastric cancer cells; Apoptosis

AIM:To explore the potential of β-elemene as a radiosensitizer for gastric cancer cells and the underlying mechanisms.METHODS:SGC7901,MKN45,MKN28,N87,and AGS human gastric cancer cell lines were used to screen for radioresistant gastric cancer cell lines. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylt...