Resolvin E2 formation and impact in inflammation resolution

• Published in: The Journal of immunology (1950) Vol. 188; no. 9; pp. 4527 - 4534
• Main Authors: Oh, Sungwhan F, Dona, Maria, Fredman, Gabrielle, Krishnamoorthy, Sriram, Irimia, Daniel, Serhan, Charles N
• Format: Journal Article
• Language: English
• Published: United States 01.05.2012
• Subjects: Animals; Chemotaxis - drug effects; Chemotaxis - immunology; Down-Regulation - drug effects; Down-Regulation - immunology; Eicosapentaenoic Acid - analogs & derivatives; Eicosapentaenoic Acid - blood; Eicosapentaenoic Acid - immunology; Eicosapentaenoic Acid - pharmacology; Female; Humans; Immunity, Innate; Inflammation - blood; Inflammation - immunology; Inflammation - pathology; Integrins - biosynthesis; Integrins - immunology; Male; Mice; Neutrophils - immunology; Neutrophils - metabolism; Neutrophils - pathology; Phagocytosis - drug effects; Phagocytosis - immunology; Platelet Activating Factor - immunology; Platelet Activating Factor - metabolism

Acute inflammation and its resolution are essential processes for tissue protection and homeostasis. In this context, specialized proresolving mediators derived from polyunsaturated fatty acids are of interest. In this study, we report that resolvin E2 (RvE2) from eicosapentaenoic acid is endogenous...