Ezetimibe reduces enlarged prostate in an animal model of benign prostatic hyperplasia
Benign prostatic hyperplasia is a common urinary tract disorder that affects aging men. The molecular mechanisms underlying benign prostatic hyperplasia are obscure and the development of animal models to test novel treatment strategies is challenging. We report that the Bio 87.20 hamster strain (Bi...
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Published in | The Journal of urology Vol. 184; no. 4; p. 1555 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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United States
01.10.2010
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Abstract | Benign prostatic hyperplasia is a common urinary tract disorder that affects aging men. The molecular mechanisms underlying benign prostatic hyperplasia are obscure and the development of animal models to test novel treatment strategies is challenging. We report that the Bio 87.20 hamster strain (Bio Breeders, Watertown, Massachusetts) shows 5α-reductase-sensitive prostate enlargement and a decrease in circulating cholesterol reduces prostate size.
Bio 87.20 hamsters 17 months old with an enlarged prostate were fed a diet containing no or minimal cholesterol and including finasteride (Merck, Whitehouse Station, New Jersey) and/or ezetimibe (Schering-Plough, Kenilworth, New Jersey) for 4 months. The prostate complex was removed, volume and weight were determined, and tissue was examined histologically.
Prostate enlargement depended on cholesterol in the diet. Blockade of intestinal cholesterol transport with ezetimibe induced prostate regression to a similar extent as the 5α-reductase inhibitor finasteride, a compound used to treat benign prostatic hyperplasia in humans. Histological analysis indicated that finasteride induced widespread prostatic atrophy but normal glandular architecture was preserved in the ezetimibe cohort.
Results indicate that dysregulation of cholesterol metabolism may be a component of benign prostatic hyperplasia and ezetimibe may be effective as an alternative or adjunct to standard treatment. Our findings also show that the Bio 87.20 hamster is a suitable model for preclinical evaluation of novel benign prostatic hyperplasia therapy. |
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AbstractList | Benign prostatic hyperplasia is a common urinary tract disorder that affects aging men. The molecular mechanisms underlying benign prostatic hyperplasia are obscure and the development of animal models to test novel treatment strategies is challenging. We report that the Bio 87.20 hamster strain (Bio Breeders, Watertown, Massachusetts) shows 5α-reductase-sensitive prostate enlargement and a decrease in circulating cholesterol reduces prostate size.
Bio 87.20 hamsters 17 months old with an enlarged prostate were fed a diet containing no or minimal cholesterol and including finasteride (Merck, Whitehouse Station, New Jersey) and/or ezetimibe (Schering-Plough, Kenilworth, New Jersey) for 4 months. The prostate complex was removed, volume and weight were determined, and tissue was examined histologically.
Prostate enlargement depended on cholesterol in the diet. Blockade of intestinal cholesterol transport with ezetimibe induced prostate regression to a similar extent as the 5α-reductase inhibitor finasteride, a compound used to treat benign prostatic hyperplasia in humans. Histological analysis indicated that finasteride induced widespread prostatic atrophy but normal glandular architecture was preserved in the ezetimibe cohort.
Results indicate that dysregulation of cholesterol metabolism may be a component of benign prostatic hyperplasia and ezetimibe may be effective as an alternative or adjunct to standard treatment. Our findings also show that the Bio 87.20 hamster is a suitable model for preclinical evaluation of novel benign prostatic hyperplasia therapy. |
Author | Insabato, Luigi Pelton, Kristine Solomon, Keith R Di Vizio, Dolores Freeman, Michael R Schaffner, Carl P |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20728125$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1002_pros_22829 crossref_primary_10_1016_j_purol_2012_01_005 crossref_primary_10_23736_S1825_859X_22_00131_1 crossref_primary_10_1371_journal_pone_0039448 crossref_primary_10_1016_j_ajur_2020_06_001 crossref_primary_10_1111_iju_13265 crossref_primary_10_1016_j_steroids_2010_12_014 crossref_primary_10_1016_j_juro_2011_11_081 crossref_primary_10_3389_fphar_2022_831657 crossref_primary_10_1002_pros_22686 crossref_primary_10_1016_j_diff_2011_04_005 crossref_primary_10_1111_bju_12728 |
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SubjectTerms | Animals Anticholesteremic Agents - therapeutic use Azetidines - therapeutic use Cricetinae Disease Models, Animal Ezetimibe Male Prostatic Hyperplasia - drug therapy Prostatic Hyperplasia - pathology |
Title | Ezetimibe reduces enlarged prostate in an animal model of benign prostatic hyperplasia |
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