A retrospective evaluation of shortened-duration oral N-acetylcysteine for the treatment of acetaminophen poisoning

• Published in: Journal of medical toxicology Vol. 5; no. 4; pp. 183 - 190
• Main Authors: Betten, David P., Burner, Elizabeth E., Thomas, Stephen C., Tomaszewski, Christian, Clark, Richard F.
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01.12.2009; Springer Nature B.V
• Subjects: Acetaminophen; Acetaminophen - poisoning; Acetylcysteine; Acetylcysteine - administration & dosage; Administration, Oral; Adolescent; Adult; Aged; Analgesics; Analgesics, Non-Narcotic - poisoning; Antidotes - administration & dosage; Biomedical and Life Sciences; Biomedicine; California; Chemical and Drug Induced Liver Injury - etiology; Chemical and Drug Induced Liver Injury - prevention & control; Criteria; Drug Administration Schedule; Drug dosages; Emergency medical care; FDA approval; Female; Hepatotoxicity; Humans; Male; Medicine; Middle Aged; Patients; Pharmacology/Toxicology; Poison Control Centers; Poisoning; Poisoning - drug therapy; Practice Guidelines as Topic; Retrospective Studies; Toxicology; Toxicology Investigations; Treatment Outcome; Young Adult; acetaminophen overdose; acetaminophen poisoning; N-acetylcysteine

Introduction The use of less than the traditional 72-hour course of oral N-acetylcysteine has been an alternative treatment option following potentially toxic acute and chronic acetaminophen ingestions felt to be at low risk of developing hepatotoxicity. While clinical experience with shortened trea...