Immune dysfunction in cirrhosis

• Published in: World journal of gastroenterology : WJG Vol. 20; no. 10; pp. 2564 - 2577
• Main Author: Sipeki, Nora
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Co., Limited 14.03.2014
• Subjects: Adaptive Immunity; Animals; Bacterial Infections - immunology; Bacterial Infections - microbiology; Bacterial Infections - mortality; Cirrhosis; Complement System Proteins - metabolism; Disease Progression; dysfunction; End Stage Liver Disease - immunology; End Stage Liver Disease - mortality; Endotoxemia; Humans; Immune; Immunity, Innate; Inflammation Mediators - metabolism; Liver Cirrhosis - complications; Liver Cirrhosis - diagnosis; Liver Cirrhosis - immunology; Liver Cirrhosis - metabolism; Liver Cirrhosis - mortality; Liver Failure, Acute - immunology; Liver Failure, Acute - mortality; Macrophages - immunology; Monocytes - immunology; Neutrophils - immunology; Prognosis; Risk Factors; Signal Transduction; Topic Highlight; Cirrhosis; Immune dysfunction; Endotoxemia

Innate and adaptive immune dysfunction,also referred to as cirrhosis-associated immune dysfunction syndrome,is a major component of cirrhosis,and plays a pivotal role in the pathogenesis of both the acute and chronic worsening of liver function.During the evolution of the disease,acute decompensatio...