Tumor immune microenvironment lncRNAs

• Published in: Briefings in bioinformatics Vol. 23; no. 1
• Main Authors: Park, Eun-Gyeong, Pyo, Sung-Jin, Cui, Youxi, Yoon, Sang-Ho, Nam, Jin-Wu
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 17.01.2022; Oxford Publishing Limited (England)
• Subjects: Annotations; Base Sequence; Functionals; Gene expression; Gene sequencing; Humans; Immune response; Immune system; Immunity - genetics; Microenvironments; Neoplasms - genetics; Neoplasms - immunology; Non-coding RNA; Review; Ribonucleic acid; RNA; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Sequence Analysis, RNA; Tumor Microenvironment - genetics; Tumor Microenvironment - immunology; Tumorigenesis; Tumors; single-cell RNA-sequencing; immune cells; long non-coding RNA; tumor immune microenvironment; cell type-specific expression; bulk RNA-sequencing

Abstract Long non-coding ribonucleic acids (RNAs) (lncRNAs) are key players in tumorigenesis and immune responses. The nature of their cell type-specific gene expression and other functional evidence support the idea that lncRNAs have distinct cellular functions in the tumor immune microenvironment...