Lipid metabolism in Th17 cell function

• Published in: Pharmacology & therapeutics (Oxford) Vol. 245; p. 108411
• Main Authors: Kanno, Toshio, Nakajima, Takahiro, Miyako, Keisuke, Endo, Yusuke
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.05.2023
• Subjects: Autoimmune Diseases - metabolism; Cell Differentiation; Humans; Lipid Metabolism; Lipids; Nuclear receptor; Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism; RORγt; Th17 cells; Th17 Cells - metabolism; Nuclear receptor; GWAS; PS; iTreg; MUFA; CNS; OXPHOS; IBD; Blimp1; scRNA-seq; Th; CPT1; mTOR; SCAP; Lipid metabolism; JunB; Th17 cells; ACC; SREBP; PUFA; MS; MMPs; STAT3; EAE; FADS; PI3K–Akt; scATAC-seq; HIF1a; PPARγ; BATF; RA; ACLY; PC; CNS2; FAO; IRF4; PE; SCD; FASN; PG; AMPK; FA; RORγt

Among the subset of T helper cells, Th17 cells are known to play a crucial role in the pathogenesis of various autoimmune disorders, such as psoriasis, rheumatoid arthritis, inflammatory bowel disease, steroid-resistant asthma, and multiple sclerosis. The master transcription factor retinoid-related...