Risk factors and basic mechanisms of chronic thromboembolic pulmonary hypertension: a current understanding

• Published in: The European respiratory journal Vol. 41; no. 2; pp. 462 - 468
• Main Authors: Lang, Irene M., Pesavento, Raffaele, Bonderman, Diana, Yuan, Jason X-J.
• Format: Journal Article
• Language: English
• Published: Leeds Maney 01.02.2013
• Subjects: Animals; Biological and medical sciences; Biopsy; Blood and lymphatic vessels; Blood Coagulation; Cardiology. Vascular system; Disease Models, Animal; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Fibrinogen - metabolism; Fibrinolysis; Humans; Hypertension, Pulmonary - diagnosis; Hypertension, Pulmonary - physiopathology; Inflammation; Medical sciences; Pneumology; Pulmonary Artery - pathology; Pulmonary Embolism - diagnosis; Pulmonary Embolism - physiopathology; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases; Risk Factors; Thromboembolism - epidemiology; Thromboembolism - physiopathology; Respiratory disease; Coagulation; Cardiovascular disease; Biology; vascular biology; Review; Thrombosis; Embolism; Pulmonary hypertension; Vascular disease; Chronic; Blood vessel; Risk factor; Chronic thromboembolic pulmonary hypertension; Thromboembolism; Bibliographic review; Pneumology

All available evidence today indicates that chronic thromboembolic pulmonary hypertension (CTEPH) is primarily caused by venous thromboembolism, as opposed to primary pulmonary vascular in situ thrombosis. Both the initial magnitude of clot and pulmonary embolism (PE) recurrence may contribute to th...