Structural and Functional Association of Trypanosoma brucei MIX Protein with Cytochrome c Oxidase Complex

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Published inEukaryotic Cell Vol. 7; no. 11; pp. 1994 - 2003
Main Authors Zíková, Alena, Panigrahi, Aswini K, Uboldi, Alessandro D, Dalley, Rachel A, Handman, Emanuela, Stuart, Kenneth
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.11.2008
American Society for Microbiology (ASM)
Subjects
Adenosine Triphosphate - metabolism
Animals
Cell Division
Electron Transport Complex IV - genetics
Electron Transport Complex IV - metabolism
Gene Expression
Leishmania major
Membrane Potential, Mitochondrial
Mitochondrial Proteins - genetics
Mitochondrial Proteins - metabolism
Protein Binding
Protozoan Proteins - genetics
Protozoan Proteins - metabolism
Trypanosoma brucei
Trypanosoma brucei brucei - genetics
Trypanosoma brucei brucei - growth & development
Trypanosoma brucei brucei - metabolism
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Abstract Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue EC About EC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy EC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 1535-9778 Online ISSN: 1535-9786 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to EC .asm.org, visit: EC       
AbstractList A mitochondrial inner membrane protein, designated MIX, seems to be essential for cell viability. The deletion of both alleles was not possible, and the deletion of a single allele led to a loss of virulence and aberrant mitochondrial segregation and cell division in Leishmania major . However, the mechanism by which MIX exerts its effect has not been determined. We show here that MIX is also expressed in the mitochondrion of Trypanosoma brucei , and using RNA interference, we found that its loss leads to a phenotype that is similar to that described for Leishmania . The loss of MIX also had a major effect on cytochrome c oxidase activity, on the mitochondrial membrane potential, and on the production of mitochondrial ATP by oxidative phosphorylation. Using a tandem affinity purification tag, we found that MIX is associated with a multiprotein complex that contains subunits of the mitochondrial cytochrome c oxidase complex (respiratory complex IV), the composition of which was characterized in detail. The specific function of MIX is unknown, but it appears to be important for the function of complex IV and for mitochondrial segregation and cell division in T. brucei .
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A mitochondrial inner membrane protein, designated MIX, seems to be essential for cell viability. The deletion of both alleles was not possible, and the deletion of a single allele led to a loss of virulence and aberrant mitochondrial segregation and cell division in Leishmania major. However, the mechanism by which MIX exerts its effect has not been determined. We show here that MIX is also expressed in the mitochondrion of Trypanosoma brucei, and using RNA interference, we found that its loss leads to a phenotype that is similar to that described for Leishmania. The loss of MIX also had a major effect on cytochrome c oxidase activity, on the mitochondrial membrane potential, and on the production of mitochondrial ATP by oxidative phosphorylation. Using a tandem affinity purification tag, we found that MIX is associated with a multiprotein complex that contains subunits of the mitochondrial cytochrome c oxidase complex (respiratory complex IV), the composition of which was characterized in detail. The specific function of MIX is unknown, but it appears to be important for the function of complex IV and for mitochondrial segregation and cell division in T. brucei.
Author Aswini K. Panigrahi
Alessandro D. Uboldi
Rachel A. Dalley
Emanuela Handman
Kenneth Stuart
Alena Zíková
AuthorAffiliation Seattle Biomedical Research Institute, Seattle, Washington 98109, 1 Walter and Eliza Hall Institute of Medical Research, Victoria, Australia 2
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Cites_doi 10.1016/j.pt.2005.06.008
10.1074/mcp.M700490-MCP200
10.1016/S0166-6851(02)00235-9
10.1007/BF00763067
10.1074/jbc.M604126200
10.1089/153623102760092805
10.1016/0014-5793(96)00095-6
10.1074/jbc.M008405200
10.1111/j.1365-2958.2005.04813.x
10.1007/s002940050525
10.1074/jbc.M404861200
10.1021/ac0341261
10.1016/S0166-6851(00)00303-0
10.1038/sj.embor.7400979
10.1242/jcs.01649
10.1074/jbc.M511504200
10.1016/S1097-2765(03)00286-7
10.1128/MCB.21.20.6833-6840.2001
10.1016/j.pt.2005.02.008
10.1074/jbc.M907246199
10.1073/pnas.022522299
10.1093/nar/gkl598
10.1074/jbc.M205776200
10.1093/emboj/20.1.262
10.1038/13732
10.1091/mbc.e05-07-0678
10.1006/meth.2001.1183
10.1016/S0021-9258(19)84639-2
10.1016/j.molbiopara.2006.04.007
10.1128/EC.00141-06
10.1016/S0020-7519(01)00296-X
10.1038/415141a
10.1074/mcp.M700430-MCP200
10.1016/j.tibs.2004.12.006
10.1016/j.ijpara.2006.08.006
10.1016/S0166-6851(99)00002-X
10.1073/pnas.2135385100
10.1261/rna.2194603
10.1007/s00436-005-1337-3
10.1016/0166-6851(96)02648-5
10.1016/j.mib.2007.10.005
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Corresponding author. Mailing address: Seattle Biomedical Research Institute, 307 Westlake Ave. North, Suite 500, Seattle, WA 98109-5219. Phone: (206) 256-7316. Fax: (206) 256-7229. E-mail: ken.stuart@sbri.org
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References e_1_3_2_26_2
e_1_3_2_27_2
e_1_3_2_28_2
e_1_3_2_29_2
e_1_3_2_41_2
e_1_3_2_40_2
e_1_3_2_20_2
e_1_3_2_43_2
e_1_3_2_21_2
e_1_3_2_42_2
e_1_3_2_22_2
e_1_3_2_23_2
e_1_3_2_44_2
e_1_3_2_24_2
e_1_3_2_25_2
e_1_3_2_9_2
e_1_3_2_15_2
e_1_3_2_38_2
e_1_3_2_8_2
e_1_3_2_16_2
e_1_3_2_37_2
e_1_3_2_7_2
(e_1_3_2_13_2) 2006; 151
e_1_3_2_17_2
e_1_3_2_6_2
e_1_3_2_18_2
e_1_3_2_39_2
e_1_3_2_19_2
e_1_3_2_30_2
e_1_3_2_32_2
e_1_3_2_10_2
e_1_3_2_31_2
e_1_3_2_5_2
e_1_3_2_11_2
e_1_3_2_34_2
e_1_3_2_4_2
e_1_3_2_12_2
e_1_3_2_33_2
e_1_3_2_3_2
e_1_3_2_36_2
e_1_3_2_2_2
e_1_3_2_14_2
e_1_3_2_35_2
References_xml – ident: e_1_3_2_16_2
  doi: 10.1016/j.pt.2005.06.008
– ident: e_1_3_2_44_2
  doi: 10.1074/mcp.M700490-MCP200
– ident: e_1_3_2_18_2
  doi: 10.1016/S0166-6851(02)00235-9
– ident: e_1_3_2_26_2
  doi: 10.1007/BF00763067
– ident: e_1_3_2_6_2
  doi: 10.1074/jbc.M604126200
– ident: e_1_3_2_14_2
  doi: 10.1089/153623102760092805
– ident: e_1_3_2_33_2
  doi: 10.1016/0014-5793(96)00095-6
– ident: e_1_3_2_40_2
  doi: 10.1074/jbc.M008405200
– ident: e_1_3_2_11_2
  doi: 10.1111/j.1365-2958.2005.04813.x
– ident: e_1_3_2_30_2
  doi: 10.1007/s002940050525
– ident: e_1_3_2_15_2
  doi: 10.1074/jbc.M404861200
– ident: e_1_3_2_22_2
  doi: 10.1021/ac0341261
– ident: e_1_3_2_2_2
  doi: 10.1016/S0166-6851(00)00303-0
– ident: e_1_3_2_21_2
  doi: 10.1038/sj.embor.7400979
– volume: 151
  start-page: 28
  year: 2006
  ident: e_1_3_2_13_2
  publication-title: Mol. Biochem. Parasitol.
– ident: e_1_3_2_19_2
  doi: 10.1242/jcs.01649
– ident: e_1_3_2_38_2
  doi: 10.1074/jbc.M511504200
– ident: e_1_3_2_29_2
  doi: 10.1016/S1097-2765(03)00286-7
– ident: e_1_3_2_23_2
  doi: 10.1128/MCB.21.20.6833-6840.2001
– ident: e_1_3_2_4_2
  doi: 10.1016/j.pt.2005.02.008
– ident: e_1_3_2_12_2
  doi: 10.1074/jbc.M907246199
– ident: e_1_3_2_37_2
  doi: 10.1073/pnas.022522299
– ident: e_1_3_2_20_2
  doi: 10.1093/nar/gkl598
– ident: e_1_3_2_5_2
  doi: 10.1074/jbc.M205776200
– ident: e_1_3_2_42_2
  doi: 10.1093/emboj/20.1.262
– ident: e_1_3_2_28_2
  doi: 10.1038/13732
– ident: e_1_3_2_3_2
  doi: 10.1091/mbc.e05-07-0678
– ident: e_1_3_2_27_2
  doi: 10.1006/meth.2001.1183
– ident: e_1_3_2_8_2
  doi: 10.1016/S0021-9258(19)84639-2
– ident: e_1_3_2_43_2
  doi: 10.1016/j.molbiopara.2006.04.007
– ident: e_1_3_2_17_2
– ident: e_1_3_2_36_2
  doi: 10.1128/EC.00141-06
– ident: e_1_3_2_31_2
  doi: 10.1016/S0020-7519(01)00296-X
– ident: e_1_3_2_9_2
  doi: 10.1038/415141a
– ident: e_1_3_2_25_2
  doi: 10.1074/mcp.M700430-MCP200
– ident: e_1_3_2_35_2
  doi: 10.1016/j.tibs.2004.12.006
– ident: e_1_3_2_39_2
  doi: 10.1016/j.ijpara.2006.08.006
– ident: e_1_3_2_41_2
  doi: 10.1016/S0166-6851(99)00002-X
– ident: e_1_3_2_32_2
  doi: 10.1073/pnas.2135385100
– ident: e_1_3_2_24_2
  doi: 10.1261/rna.2194603
– ident: e_1_3_2_7_2
  doi: 10.1007/s00436-005-1337-3
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A mitochondrial inner membrane protein, designated MIX, seems to be essential for cell viability. The deletion of both alleles was not possible, and the...
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StartPage 1994
SubjectTerms Adenosine Triphosphate - metabolism
Animals
Cell Division
Electron Transport Complex IV - genetics
Electron Transport Complex IV - metabolism
Gene Expression
Leishmania major
Membrane Potential, Mitochondrial
Mitochondrial Proteins - genetics
Mitochondrial Proteins - metabolism
Protein Binding
Protozoan Proteins - genetics
Protozoan Proteins - metabolism
Trypanosoma brucei
Trypanosoma brucei brucei - genetics
Trypanosoma brucei brucei - growth & development
Trypanosoma brucei brucei - metabolism
Title Structural and Functional Association of Trypanosoma brucei MIX Protein with Cytochrome c Oxidase Complex
URI http://ec.asm.org/content/7/11/1994.abstract
https://www.ncbi.nlm.nih.gov/pubmed/18776036
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