Phase I/II study of streptozocin monotherapy in Japanese patients with unresectable or metastatic gastroenteropancreatic neuroendocrine tumors

• Published in: Japanese journal of clinical oncology Vol. 52; no. 7; pp. 716 - 724
• Main Authors: Komoto, Izumi, Kokudo, Norihiro, Aoki, Taku, Morizane, Chigusa, Ito, Tetsuhide, Hashimoto, Takuya, Kimura, Wataru, Inoue, Naoya, Hasegawa, Kiyoshi, Kondo, Shunsuke, Ueno, Hideki, Igarashi, Hisato, Oono, Takamasa, Makuuchi, Masatoshi, Takamoto, Takeshi, Hirai, Ichiro, Takeshita, Akiko, Imamura, Masayuki
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 08.07.2022
• Subjects: Original; disease control; neuroendocrine tumor; streptozocin; tumor shrinkage

Abstract Background This phase I/II study was conducted to evaluate the efficacy, safety and pharmacokinetics of streptozocin (STZ) in Japanese patients with unresectable or metastatic gastroenteropancreatic neuroendocrine tumors. Methods Twenty-two patients received up to 4 cycles of intravenous ST...