TLR15 is unique to avian and reptilian lineages and recognizes a yeast-derived agonist

• Published in: The Journal of immunology (1950) Vol. 189; no. 10; pp. 4930 - 4938
• Main Authors: Boyd, Amy C, Peroval, Marylene Y, Hammond, John A, Prickett, Michael D, Young, John R, Smith, Adrian L
• Format: Journal Article
• Language: English
• Published: United States 15.11.2012
• Subjects: Animals; Antigens, Fungal - chemistry; Antigens, Fungal - immunology; Avian Proteins - genetics; Avian Proteins - immunology; Birds - genetics; Birds - immunology; Candida albicans; Evolution, Molecular; HEK293 Cells; Humans; Interleukin-1beta - genetics; Interleukin-1beta - immunology; Lizards - genetics; Lizards - immunology; NF-kappa B - genetics; NF-kappa B - immunology; Saccharomyces cerevisiae; Schizosaccharomyces pombe; Signal Transduction - physiology; Species Specificity; Toll-Like Receptors - agonists; Toll-Like Receptors - genetics; Toll-Like Receptors - immunology; Yeasts - chemistry; Yeasts - immunology

The TLRs represent a family of pattern recognition receptors critical in the induction of vertebrate immune responses. Between 10 and 13 different TLR genes can be identified in each vertebrate species, with many represented as orthologous genes in different species. The agonist specificity of ortho...