Multi-stage delivery nano-particle systems for therapeutic applications

• Published in: Biochimica et biophysica acta Vol. 1810; no. 3; pp. 317 - 329
• Main Authors: Serda, Rita E., Godin, Biana, Blanco, Elvin, Chiappini, Ciro, Ferrari, Mauro
• Format: Journal Article
• Language: English
• Published: Netherlands 01.03.2011
• Subjects: Animals; blood serum; cell adhesion; cell viability; cytokines; Drug Delivery Systems; drugs; encapsulation; endothelial cells; evolution; Humans; image analysis; in vivo studies; macrophages; mitosis; nanomedicine; nanoparticles; Nanoparticles - chemistry; Nanoparticles - therapeutic use; opsonins; Porosity; silicon; Silicon - chemistry; small interfering RNA; therapeutics

The daunting task for drug molecules to reach pathological lesions has fueled rapid advances in Nanomedicine. The progressive evolution of nanovectors has led to the development of multi-stage delivery systems aimed at overcoming the numerous obstacles encountered by nanovectors on their journey to...