Improved Efficacy of Liposomal Doxorubicin Treatment of Superficial Tumors by Thermotherapy

• Published in: Technology in cancer research & treatment Vol. 15; no. 2; pp. 314 - 321
• Main Authors: Ping, Xiong, Angang, Ding, Xia, Gong, Yinzhu, Zhao, Jia, Li, Guofeng, Shen, Yazhu, Chen
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.04.2016; Sage Publications Ltd
• Subjects: Animals; Antibiotics, Antineoplastic - administration & dosage; Antibiotics, Antineoplastic - pharmacokinetics; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - therapy; Cell Line, Tumor; Chemotherapy; Combined Modality Therapy; Doxorubicin; Doxorubicin - administration & dosage; Doxorubicin - analogs & derivatives; Doxorubicin - pharmacokinetics; Drug Screening Assays, Antitumor; High-performance liquid chromatography; Hyperthermia, Induced; Neoplasm Transplantation; Polyethylene Glycols - administration & dosage; Polyethylene Glycols - pharmacokinetics; Rabbits; Thermotherapy; Tissue Distribution; Treatment Outcome; Tumor Burden; Tumors; drug carriers; drug delivery systems; hyperthermia induced; doxorubicin; liposomes

Our study aimed to investigate the effect of ultrasonic thermotherapy on the targeted delivery of liposomal doxorubicin to superficial tumors, local drug concentrations in tumor tissue, and the curative effect of chemotherapy. Twenty rabbits with VX2 tumors transplanted into the superficial muscle o...