Biological network analysis with deep learning

• Published in: Briefings in bioinformatics Vol. 22; no. 2; pp. 1515 - 1530
• Main Authors: Muzio, Giulia, O’Bray, Leslie, Borgwardt, Karsten
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 22.03.2021; Oxford Publishing Limited (England)
• Subjects: Algorithms; Bioinformatics; Biological activity; Chemical bonds; Chemical compounds; Computational Biology - methods; Computer applications; Deep Learning; Drug Discovery; Gene Regulatory Networks; Graph neural networks; Humans; Machine learning; Network analysis; Neural networks; Neural Networks, Computer; Predictions; Proteins; Software; drug development; deep learning; drug-target prediction; protein function prediction; protein interaction prediction; biological networks

Abstract Recent advancements in experimental high-throughput technologies have expanded the availability and quantity of molecular data in biology. Given the importance of interactions in biological processes, such as the interactions between proteins or the bonds within a chemical compound, this da...