Heat-killed Lactobacillus paracasei K71 isolated from Sakekasu (sake lees) enhances Th1 response, NK cell cytotoxicity and fecal IgA content in normal BALB/c mice

• Published in: FOOD SCIENCE AND TECHNOLOGY RESEARCH Vol. 28; no. 4; pp. 335 - 341
• Main Authors: Hara, Takashi, Igarashi, Akira, Teradaira, Takuya, Joh, Toshio
• Format: Journal Article
• Language: English
• Published: Tsukuba Japanese Society for Food Science and Technology 01.01.2022; The Japanese Society for Food Science and Technology; Japan Science and Technology Agency
• Subjects: Cell culture; Cytotoxicity; Dietary supplements; fecal IgA; Heat; IFN-γ; Immune response; Immunoglobulin A; Immunoglobulin G; Immunostimulation; Innate immunity; Interleukin 12; Interleukin 4; Lactobacilli; Lactobacillus paracasei; Lactobacillus paracasei K71; Lymphocytes T; Natural killer cells; NK cells; Spleen; Th1 type immune responses; Toxicity; Tumorigenesis; γ-Interferon

Lactobacillus paracasei K71 (K71) isolated from Japanese sake lees (Sakekasu) was previously shown to enhance IL-12 production in mouse spleen cell culture. In this study, we examined whether heat-killed K71 exerts immunostimulatory effects in normal BALB/c mice. Six-week dietary supplementation wit...