Molecular insights into the regulation of constitutive activity by RNA editing of 5HT2C serotonin receptors

• Published in: Cell reports (Cambridge) Vol. 40; no. 7; p. 111211
• Main Authors: Gumpper, Ryan H., Fay, Jonathan F., Roth, Bryan L.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 16.08.2022
• Subjects: 5HT2CR; constitutive activity; G-protein-coupled receptor; Gq protein; lorcaserin; psilocin; serotonin; structural biology; Gq protein; serotonin; constitutive activity; G-protein-coupled receptor; CP: Molecular biology; lorcaserin; structural biology; psilocin; 5HT2CR

RNA editing is a process by which post-transcriptional changes of mRNA nucleotides alter protein function through modification of the amino acid content. The 5HT2C serotonin receptor, which undergoes 32 distinct RNA-editing events leading to 24 protein isoforms, is a notable example of this process....