Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses

• Published in: The Journal of immunology (1950) Vol. 189; no. 4; pp. 1983 - 1991
• Main Authors: Rogerio, Alexandre P, Haworth, Oliver, Croze, Roxanne, Oh, Sungwhan F, Uddin, Mohib, Carlo, Troy, Pfeffer, Michael A, Priluck, Rebekah, Serhan, Charles N, Levy, Bruce D
• Format: Journal Article
• Language: English
• Published: United States 15.08.2012
• Subjects: Animals; Aspirin - pharmacology; Asthma - immunology; Asthma - metabolism; Blotting, Western; Bronchoalveolar Lavage Fluid - chemistry; Bronchoalveolar Lavage Fluid - immunology; Chemotaxis, Leukocyte - immunology; Cytokines - biosynthesis; Disease Models, Animal; Docosahexaenoic Acids - immunology; Docosahexaenoic Acids - metabolism; Gene Expression Profiling; Hypersensitivity - immunology; Hypersensitivity - metabolism; Immunohistochemistry; Macrophages - immunology; Male; Mice; Protein Isoforms - immunology; Protein Isoforms - metabolism; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction

Asthma is a disease of airway inflammation that in most cases fails to resolve. The resolution of inflammation is an active process governed by specific chemical mediators, including D-series resolvins. In this study, we determined the impact of resolvin D1 (RvD1) and aspirin-triggered RvD1 (AT-RvD1...