Combined Effects of ESRα DNA Methylation and Progesterone on Glucose Metabolic Disorders: The Henan Rural Cohort Study

• Published in: Nutrients Vol. 15; no. 7; p. 1659
• Main Authors: Feng, Bo, Wang, Lulu, Wei, Dandan, Huo, Wenqian, Jing, Tao, Wang, Chongjian, Mao, Zhenxing
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.03.2023; MDPI
• Subjects: Blood Glucose - metabolism; Case-Control Studies; Cholesterol; Chromatography; Cohort analysis; Cohort Studies; confidence interval; Diabetes; Diabetes Mellitus, Type 2 - genetics; DNA Methylation; Estrogen Receptor alpha - genetics; Estrogen Receptor alpha - metabolism; estrogen receptors; Estrogens; Family medical history; Female; Generalized linear models; genes; Glucose; Glucose Metabolism Disorders; Homeostasis; Humans; Insulin resistance; Kinases; Male; Menstruation; Metabolism; noninsulin-dependent diabetes mellitus; odds ratio; Population; postmenopause; Prediabetic State - complications; Progesterone; risk; Risk Factors; Rural areas; China; type 2 diabetes mellitus; combined effect; impaired fasting glucose; DNA methylation progesterone; estrogen receptor alpha

To explore the independent and combined effects of ESRα methylation and progesterone on impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM), a case-control study including 901 subjects was conducted. Generalized linear models were performed to assess the independent and combined effec...