Metabolomics, metabolic flux analysis and cancer pharmacology

• Published in: Pharmacology & therapeutics (Oxford) Vol. 224; p. 107827
• Main Authors: Liang, Lingfan, Sun, Fei, Wang, Hongbo, Hu, Zeping
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.08.2021
• Subjects: cancer; drug discovery; Humans; metabolic flux; Metabolic Flux Analysis; Metabolomics; Neoplasms - drug therapy; pharmacology; cancer; drug discovery; metabolomics; metabolic flux; pharmacology

Metabolic reprogramming is a hallmark of cancer and increasing evidence suggests that reprogrammed cell metabolism supports tumor initiation, progression, metastasis and drug resistance. Understanding metabolic dysregulation may provide therapeutic targets and facilitate drug research and developmen...