Reduced thrombogenicity of nitinol stents—In vitro evaluation of different surface modifications and coatings

• Published in: Biomaterials Vol. 27; no. 4; pp. 643 - 650
• Main Authors: Tepe, Gunnar, Schmehl, Joerg, P Wendel, Hans, Schaffner, Sivio, Heller, Stephan, Gianotti, Marc, D Claussen, Claus, H Duda, Stephan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.02.2006
• Subjects: Alloys - adverse effects; Alloys - chemistry; Anticoagulants - administration & dosage; Blood Vessel Prosthesis - adverse effects; Cells, Cultured; Coated Materials, Biocompatible - chemistry; Coated Materials, Biocompatible - therapeutic use; Equipment Failure Analysis; Heparin - administration & dosage; Heparin - chemistry; Humans; Materials Testing; Nitinol; Platelet Activation - drug effects; Platelet Activation - immunology; Polyurethane; Stent; Stents; Surface modification; Surface Properties; Thrombogenicity; Thrombosis - etiology; Thrombosis - immunology; Thrombosis - prevention & control; Surface modification; PU: polyurethane; SEM: scanning electron microscopy; TAT: thrombin–antithrombin-III-complex; FBGC: foreign body giant cell; Thrombogenicity; Polyurethane; PMN: polymorphnuclear (granulocytes); Nitinol; Stent; β-TG: beta-thromboglobulin; AT III: antithrombin III

The material and the surface patterns of intravascular stents play a pivotal role in activating platelets and triggering adherence of inflammatory cells that consecutively leads to renarrowing caused by neointimal hyperplasia. To improve these features, besides mechanical and chemical modifications,...