Design of an epitope-based peptide vaccine against the SARS-CoV-2: a vaccine-informatics approach

• Published in: Briefings in bioinformatics Vol. 22; no. 2; pp. 1309 - 1323
• Main Authors: Alam, Aftab, Khan, Arbaaz, Imam, Nikhat, Siddiqui, Mohd Faizan, Waseem, Mohd, Malik, Md Zubbair, Ishrat, Romana
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 22.03.2021; Oxford Publishing Limited (England)
• Subjects: Amino Acid Sequence; Antigens; Bone marrow; Case Study; CD4 antigen; CD8 antigen; Cell differentiation; Clusters; Computational Biology; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - prevention & control; Differentiation; Epitope mapping; Epitopes, B-Lymphocyte - chemistry; Epitopes, B-Lymphocyte - immunology; Epitopes, T-Lymphocyte - chemistry; Epitopes, T-Lymphocyte - immunology; Glycoproteins; Grooves; Histocompatibility antigen HLA; HLA Antigens - chemistry; Horizon; Humans; In vivo methods and tests; Informatics; Leukocytes; Lymphocytes T; Molecular Docking Simulation; Peptide mapping; Peptides; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Vaccine development; Vaccines; Vaccines, Subunit - chemistry; Vaccines, Subunit - immunology; Viral diseases; COVID-19; population coverage; epitope prediction; T- and B-cell; molecular docking; vaccinomics; allergenicity; immunogenicity

Abstract The recurrent and recent global outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has turned into a global concern which has infected more than 42 million people all over the globe, and this number is increasing in hours. Unfortunately, no vaccine or specific trea...