Association between habitual coffee consumption and multiple disease outcomes: A Mendelian randomisation phenome-wide association study in the UK Biobank
Coffee is the most commonly consumed beverage in the world after water, however the debate as to whether coffee consumption is beneficial or detrimental to health continues. Current evidence of the link between coffee and health outcomes is predominately observational, thus subject to methodological...
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| Published in | Clinical nutrition (Edinburgh, Scotland) Vol. 39; no. 11; pp. 3467 - 3476 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.11.2020
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0261-5614 1532-1983 1532-1983 |
| DOI | 10.1016/j.clnu.2020.03.009 |
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| Abstract | Coffee is the most commonly consumed beverage in the world after water, however the debate as to whether coffee consumption is beneficial or detrimental to health continues. Current evidence of the link between coffee and health outcomes is predominately observational, thus subject to methodological issues such a confounding and reverse causation.
This Mendelian randomisation phenome-wide association study (MR-PheWAS) used information from up to 333,214 participants of White-British ancestry in the UK Biobank to examine the causal association between genetically instrumented habitual coffee consumption and the full range of disease outcomes. We constructed a genetic risk score for habitual coffee consumption and screened for associations with disease outcomes across 1117 case-control series. All signals under false discovery rate controlled threshold (5.8 × 10−4) were followed by Mendelian randomisation (MR) analyses, with replication in independent data sources where possible.
The initial phenome-wide association analysis identified signals for 13 outcomes representing five distinct diseases. The strongest signal was seen for gout (P = 2.3 × 10−12), but there was notable pleiotropy (Pdistortion <0.001) and MR analyses did not support an association with habitual coffee consumption (inverse variance weighted MR OR 0.41, 95% CI 0.08 to 2.25, P = 0.31). Support for a possible causal relationship between habitual coffee consumption was only obtained for four distinct disease outcomes, including an increased odds of osteoarthrosis (OR 1.23, 95% CI 1.11 to 1.35), other arthropathies (OR 1.22, 95% CI 1.12 to 1.33) and overweight (OR 1.28, 95% CI 1.05 to 1.56), and a lower odds of postmenopausal bleeding (OR 0.72, 95% CI 0.63 to 0.82). Evidence for an association between habitual coffee consumption and these four diseases was also supported by phenotypic associations with self-reported coffee consumption.
This large-scale MR-PheWAS provided little evidence for notable harm or benefit with respect to higher habitual coffee consumption. The only evidence for harm was seen with respect to osteoarthrosis, other arthropathies and obesity. |
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| AbstractList | Coffee is the most commonly consumed beverage in the world after water, however the debate as to whether coffee consumption is beneficial or detrimental to health continues. Current evidence of the link between coffee and health outcomes is predominately observational, thus subject to methodological issues such a confounding and reverse causation.
This Mendelian randomisation phenome-wide association study (MR-PheWAS) used information from up to 333,214 participants of White-British ancestry in the UK Biobank to examine the causal association between genetically instrumented habitual coffee consumption and the full range of disease outcomes. We constructed a genetic risk score for habitual coffee consumption and screened for associations with disease outcomes across 1117 case-control series. All signals under false discovery rate controlled threshold (5.8 × 10−4) were followed by Mendelian randomisation (MR) analyses, with replication in independent data sources where possible.
The initial phenome-wide association analysis identified signals for 13 outcomes representing five distinct diseases. The strongest signal was seen for gout (P = 2.3 × 10−12), but there was notable pleiotropy (Pdistortion <0.001) and MR analyses did not support an association with habitual coffee consumption (inverse variance weighted MR OR 0.41, 95% CI 0.08 to 2.25, P = 0.31). Support for a possible causal relationship between habitual coffee consumption was only obtained for four distinct disease outcomes, including an increased odds of osteoarthrosis (OR 1.23, 95% CI 1.11 to 1.35), other arthropathies (OR 1.22, 95% CI 1.12 to 1.33) and overweight (OR 1.28, 95% CI 1.05 to 1.56), and a lower odds of postmenopausal bleeding (OR 0.72, 95% CI 0.63 to 0.82). Evidence for an association between habitual coffee consumption and these four diseases was also supported by phenotypic associations with self-reported coffee consumption.
This large-scale MR-PheWAS provided little evidence for notable harm or benefit with respect to higher habitual coffee consumption. The only evidence for harm was seen with respect to osteoarthrosis, other arthropathies and obesity. Coffee is the most commonly consumed beverage in the world after water, however the debate as to whether coffee consumption is beneficial or detrimental to health continues. Current evidence of the link between coffee and health outcomes is predominately observational, thus subject to methodological issues such a confounding and reverse causation.BACKGROUNDCoffee is the most commonly consumed beverage in the world after water, however the debate as to whether coffee consumption is beneficial or detrimental to health continues. Current evidence of the link between coffee and health outcomes is predominately observational, thus subject to methodological issues such a confounding and reverse causation.This Mendelian randomisation phenome-wide association study (MR-PheWAS) used information from up to 333,214 participants of White-British ancestry in the UK Biobank to examine the causal association between genetically instrumented habitual coffee consumption and the full range of disease outcomes. We constructed a genetic risk score for habitual coffee consumption and screened for associations with disease outcomes across 1117 case-control series. All signals under false discovery rate controlled threshold (5.8 × 10-4) were followed by Mendelian randomisation (MR) analyses, with replication in independent data sources where possible.METHODSThis Mendelian randomisation phenome-wide association study (MR-PheWAS) used information from up to 333,214 participants of White-British ancestry in the UK Biobank to examine the causal association between genetically instrumented habitual coffee consumption and the full range of disease outcomes. We constructed a genetic risk score for habitual coffee consumption and screened for associations with disease outcomes across 1117 case-control series. All signals under false discovery rate controlled threshold (5.8 × 10-4) were followed by Mendelian randomisation (MR) analyses, with replication in independent data sources where possible.The initial phenome-wide association analysis identified signals for 13 outcomes representing five distinct diseases. The strongest signal was seen for gout (P = 2.3 × 10-12), but there was notable pleiotropy (Pdistortion <0.001) and MR analyses did not support an association with habitual coffee consumption (inverse variance weighted MR OR 0.41, 95% CI 0.08 to 2.25, P = 0.31). Support for a possible causal relationship between habitual coffee consumption was only obtained for four distinct disease outcomes, including an increased odds of osteoarthrosis (OR 1.23, 95% CI 1.11 to 1.35), other arthropathies (OR 1.22, 95% CI 1.12 to 1.33) and overweight (OR 1.28, 95% CI 1.05 to 1.56), and a lower odds of postmenopausal bleeding (OR 0.72, 95% CI 0.63 to 0.82). Evidence for an association between habitual coffee consumption and these four diseases was also supported by phenotypic associations with self-reported coffee consumption.RESULTSThe initial phenome-wide association analysis identified signals for 13 outcomes representing five distinct diseases. The strongest signal was seen for gout (P = 2.3 × 10-12), but there was notable pleiotropy (Pdistortion <0.001) and MR analyses did not support an association with habitual coffee consumption (inverse variance weighted MR OR 0.41, 95% CI 0.08 to 2.25, P = 0.31). Support for a possible causal relationship between habitual coffee consumption was only obtained for four distinct disease outcomes, including an increased odds of osteoarthrosis (OR 1.23, 95% CI 1.11 to 1.35), other arthropathies (OR 1.22, 95% CI 1.12 to 1.33) and overweight (OR 1.28, 95% CI 1.05 to 1.56), and a lower odds of postmenopausal bleeding (OR 0.72, 95% CI 0.63 to 0.82). Evidence for an association between habitual coffee consumption and these four diseases was also supported by phenotypic associations with self-reported coffee consumption.This large-scale MR-PheWAS provided little evidence for notable harm or benefit with respect to higher habitual coffee consumption. The only evidence for harm was seen with respect to osteoarthrosis, other arthropathies and obesity.CONCLUSIONSThis large-scale MR-PheWAS provided little evidence for notable harm or benefit with respect to higher habitual coffee consumption. The only evidence for harm was seen with respect to osteoarthrosis, other arthropathies and obesity. Coffee is the most commonly consumed beverage in the world after water, however the debate as to whether coffee consumption is beneficial or detrimental to health continues. Current evidence of the link between coffee and health outcomes is predominately observational, thus subject to methodological issues such a confounding and reverse causation. This Mendelian randomisation phenome-wide association study (MR-PheWAS) used information from up to 333,214 participants of White-British ancestry in the UK Biobank to examine the causal association between genetically instrumented habitual coffee consumption and the full range of disease outcomes. We constructed a genetic risk score for habitual coffee consumption and screened for associations with disease outcomes across 1117 case-control series. All signals under false discovery rate controlled threshold (5.8 × 10 ) were followed by Mendelian randomisation (MR) analyses, with replication in independent data sources where possible. The initial phenome-wide association analysis identified signals for 13 outcomes representing five distinct diseases. The strongest signal was seen for gout (P = 2.3 × 10 ), but there was notable pleiotropy (P <0.001) and MR analyses did not support an association with habitual coffee consumption (inverse variance weighted MR OR 0.41, 95% CI 0.08 to 2.25, P = 0.31). Support for a possible causal relationship between habitual coffee consumption was only obtained for four distinct disease outcomes, including an increased odds of osteoarthrosis (OR 1.23, 95% CI 1.11 to 1.35), other arthropathies (OR 1.22, 95% CI 1.12 to 1.33) and overweight (OR 1.28, 95% CI 1.05 to 1.56), and a lower odds of postmenopausal bleeding (OR 0.72, 95% CI 0.63 to 0.82). Evidence for an association between habitual coffee consumption and these four diseases was also supported by phenotypic associations with self-reported coffee consumption. This large-scale MR-PheWAS provided little evidence for notable harm or benefit with respect to higher habitual coffee consumption. The only evidence for harm was seen with respect to osteoarthrosis, other arthropathies and obesity. Coffee is the most commonly consumed beverage in the world after water, however the debate as to whether coffee consumption is beneficial or detrimental to health continues. Current evidence of the link between coffee and health outcomes is predominately observational, thus subject to methodological issues such a confounding and reverse causation.This Mendelian randomisation phenome-wide association study (MR-PheWAS) used information from up to 333,214 participants of White-British ancestry in the UK Biobank to examine the causal association between genetically instrumented habitual coffee consumption and the full range of disease outcomes. We constructed a genetic risk score for habitual coffee consumption and screened for associations with disease outcomes across 1117 case-control series. All signals under false discovery rate controlled threshold (5.8 × 10⁻⁴) were followed by Mendelian randomisation (MR) analyses, with replication in independent data sources where possible.The initial phenome-wide association analysis identified signals for 13 outcomes representing five distinct diseases. The strongest signal was seen for gout (P = 2.3 × 10⁻¹²), but there was notable pleiotropy (Pdᵢₛₜₒᵣₜᵢₒₙ <0.001) and MR analyses did not support an association with habitual coffee consumption (inverse variance weighted MR OR 0.41, 95% CI 0.08 to 2.25, P = 0.31). Support for a possible causal relationship between habitual coffee consumption was only obtained for four distinct disease outcomes, including an increased odds of osteoarthrosis (OR 1.23, 95% CI 1.11 to 1.35), other arthropathies (OR 1.22, 95% CI 1.12 to 1.33) and overweight (OR 1.28, 95% CI 1.05 to 1.56), and a lower odds of postmenopausal bleeding (OR 0.72, 95% CI 0.63 to 0.82). Evidence for an association between habitual coffee consumption and these four diseases was also supported by phenotypic associations with self-reported coffee consumption.This large-scale MR-PheWAS provided little evidence for notable harm or benefit with respect to higher habitual coffee consumption. The only evidence for harm was seen with respect to osteoarthrosis, other arthropathies and obesity. |
| Author | Mulugeta, Anwar Nicolopoulos, Konstance Hyppönen, Elina Zhou, Ang |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32284183$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.jnutbio.2010.03.011 10.1038/nbt.2749 10.1002/gepi.21758 10.1093/ejo/cjv046 10.1038/sj.ijo.0800528 10.1038/nrg.2015.36 10.1038/ng.2500 10.1093/carcin/22.5.763 10.1136/practneurol-2015-001162 10.1016/j.toxlet.2018.06.1221 10.1093/ije/dyv080 10.1371/journal.pone.0119752 10.1038/s41467-018-08219-1 10.1007/s10067-018-4252-6 10.7326/0003-4819-133-8-200010170-00016 10.1093/ije/dyy202 10.1146/annurev-genom-090314-024956 10.1038/nrcardio.2017.78 10.1016/j.jprot.2013.01.030 10.3390/nu10101343 10.1681/ASN.2016010098 10.1016/j.imr.2014.08.002 10.1186/s12859-018-2135-0 10.1080/07315724.1996.10718571 10.1001/archinternmed.2011.393 10.1210/er.2007-0036 10.1016/S0140-6736(12)60404-8 10.1001/jama.2017.17219 10.1093/hmg/ddy163 10.1080/01635581.2010.492083 10.1016/j.foodchem.2011.09.024 10.1016/j.canlet.2004.10.007 10.1093/ajcn/nqy297 10.1136/bmj.j5375 10.1001/jamacardio.2016.5804 10.1111/j.2517-6161.1995.tb02031.x 10.1016/j.foodchem.2012.03.095 10.1016/j.puhe.2016.12.033 10.1371/journal.pone.0175508 10.1152/ajpregu.00832.2005 10.1038/mp.2014.107 10.1093/ije/dyg070 10.1186/s12916-017-0862-0 10.1146/annurev-nutr-071816-064941 10.1093/ije/dyv083 10.1038/s41588-018-0099-7 10.1016/j.vph.2018.03.002 10.1038/oby.2005.142 10.1093/ije/dyu005 10.1093/aje/kwx246 10.1093/ajcn/51.5.759 10.7554/eLife.34408 10.1136/bmj.k601 10.1093/ije/dyx102 10.1186/s13075-018-1629-5 10.1016/j.gene.2017.01.008 10.1136/annrheumdis-2018-213055 10.1001/jama.2010.1686 10.1016/j.toxlet.2012.09.007 10.1007/s11101-011-9212-6 10.1016/j.hlpt.2012.07.003 10.1093/ajcn/49.1.44 10.1002/gepi.21965 |
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| Keywords | PheWAS UK Biobank Mendelian randomisation Coffee consumption |
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| References | Denny, Bastarache, Roden (bib18) 2016; 17 Hemani, Zheng, Elsworth, Wade, Baird, Haberland (bib33) 2018; 7 Lucas, Mirzaei, Pan, Okereke, Willet, O'Reilly (bib2) 2011; 171 Soares, Schneider, Valle, Schenkel (bib65) 2018; 106 Cornelis, Munafo (bib62) 2018; 10 Nordestgaard, Thomsen, Nordestgaard (bib48) 2015; 44 UK Biobank (bib20) 2018 Benjamini, Hochberg (bib30) 1995; 57 Manolio, Collins (bib70) 2010; 304 Tai, Cheung, Chan, Hasman (bib4) 2010; 62 Cornelis, Byrne, Esko, Nalls, Ganna, Paynter (bib19) 2015; 20 Wang, Huang, Kang, Zheng, Jensen, Wiggs (bib47) 2017; 15 Collins (bib68) 2012; 379 Dulloo, Geissler, Horton, Collins, Miller (bib50) 1989; 49 Luo, Li, Cao, Tan, Magdalou, Chen (bib44) 2015; 5 Verbanck, Chen, Neale, Do (bib37) 2018; 50 NHGRI-EBI (bib57) 2017 Stata Corp (bib29) 1996 Huffman, Albrecht, Teumer, Mangino, Kapur, Johnson (bib59) 2015; 10 Denny, Bastarache, Ritchie, Carroll, Zink, Mosley (bib25) 2013; 31 Hudson, Schulte, Sutter, Norris (bib56) 2001; 22 Gkatzionis, Burgess (bib67) 2018; 48 UK Biobank (bib24) 2018 Davies, Holmes, Davey Smith (bib61) 2018; 362 Sekula, Del Greco, Pattaro, Köttgen (bib15) 2016; 27 UK Biobank (bib21) 2007 Lee (bib41) 2018; 37 Larsson, Traylor, Malik, Dichgans, Burgess, Markus (bib60) 2017; 359 Grosso, Godos, Galvano, Giovannucci (bib11) 2017; 37 Emdin, Khera, Sekar (bib16) 2017; 19 Tan, Lu, Li, Ni, Zhao, Magdalou (bib43) 2018; 295 Bae, Park, Im, Song (bib1) 2014; 3 Davey Smith, Ebrahim (bib13) 2003; 32 Burgess (bib28) 2014; 43 Holmes, Ala-Korpela, Smith (bib63) 2017; 14 Astrup, Toubro, Cannon, Hein, Breum, Madsen (bib49) 1990; 51 Greay, Hammer (bib5) 2015; 14 Hemani, Bowden, Davey Smith (bib31) 2018; 27 Wei, Bastarache, Carroll, Marlo, Osterman, Gamazon (bib26) 2017; 12 Lyall, Celis-Morales, Ward, Iliodromiti, Anderson, Gill (bib22) 2017; 2 Diepvens, Westerterp, Westerterp-Plantenga (bib53) 2007; 292 Felson, Lawrence, Dieppe, Hirsch, Helmick, Jordan (bib42) 2000; 133 Poole, Kennedy, Roderick, Fallowfield, Hayes, Parkes (bib10) 2017; 359 Hutton, Fatima, Major, Topless, Stamp, Merriman (bib39) 2018; 20 Bowden, Davey Smith, Haycock, Burgess (bib35) 2016; 40 Soroko, Chang, Barrett-Connor (bib40) 1996; 15 Nehlig (bib9) 2015; 16 Hartwig, Davey Smith, Bowden (bib36) 2017; 46 Pasman, Westerterp-Plantenga, Saris (bib51) 1997; 21 Burgess, Butterworth, Thompson (bib32) 2013; 37 Giustina, Mazziotti, Canalis (bib45) 2008; 29 Chu, Chen, Brown, Lyle, Black, Cheng (bib8) 2012; 131 Bondemark, Ruf (bib12) 2015; 37 Fry, Littlejohns, Sudlow, Doherty, Adamska, Sprosen (bib66) 2017; 186 Tsuchiya, Nakajima, Yokoi (bib55) 2005; 227 Verma, Bradford, Dudek, Lucas, Verma, Pendergrass (bib27) 2018; 19 Bowden, Davey Smith, Burgess (bib34) 2015; 44 Haworth, Mitchell, Corbin, Wade, Dudding, Budu-Aggrey (bib71) 2019; 10 Gupta, Walia, Sachdeva (bib14) 2017; 145 Westerterp-Plantenga, Lejeune, Kovacs (bib52) 2005; 13 Niseteo, Komes, Belščak-Cvitanović, Horžić, Budeč (bib7) 2012; 134 Kottgen, Albrecht, Teumer, Vitart, Krumsiek, Hundertmark (bib58) 2013; 45 Bush, Oetjens, Crawford (bib17) 2016; 17 Allen, Sudlow, Downey, Peakman, Danesh, Elliott (bib69) 2012; 1 Larsson, Carlstrom (bib38) 2018; 77 Sutherland, Champion, Plays, Stuart, Haupt, Frith (bib54) 2017; 607 Dal Piaz, Cotugno, Lepore, Vassallo, Malafronte, Lauro (bib3) 2013; 82 Boettler, Sommerfeld, Volz, Pahlke, Teller, Somoza (bib6) 2011; 22 Tan, Liu, Deng, Cao, Xu, Cu (bib46) 2012; 214 Zhou, Hypponen (bib23) 2019; 109 Zhou, Hyppönen (bib64) 2019; 109 Grosso (10.1016/j.clnu.2020.03.009_bib11) 2017; 37 Wei (10.1016/j.clnu.2020.03.009_bib26) 2017; 12 Cornelis (10.1016/j.clnu.2020.03.009_bib62) 2018; 10 Astrup (10.1016/j.clnu.2020.03.009_bib49) 1990; 51 Zhou (10.1016/j.clnu.2020.03.009_bib64) 2019; 109 Soroko (10.1016/j.clnu.2020.03.009_bib40) 1996; 15 NHGRI-EBI (10.1016/j.clnu.2020.03.009_bib57) 2017 Davies (10.1016/j.clnu.2020.03.009_bib61) 2018; 362 Larsson (10.1016/j.clnu.2020.03.009_bib60) 2017; 359 UK Biobank (10.1016/j.clnu.2020.03.009_bib21) 2007 Boettler (10.1016/j.clnu.2020.03.009_bib6) 2011; 22 Wang (10.1016/j.clnu.2020.03.009_bib47) 2017; 15 Collins (10.1016/j.clnu.2020.03.009_bib68) 2012; 379 Cornelis (10.1016/j.clnu.2020.03.009_bib19) 2015; 20 Hutton (10.1016/j.clnu.2020.03.009_bib39) 2018; 20 Bush (10.1016/j.clnu.2020.03.009_bib17) 2016; 17 Denny (10.1016/j.clnu.2020.03.009_bib25) 2013; 31 Soares (10.1016/j.clnu.2020.03.009_bib65) 2018; 106 Gkatzionis (10.1016/j.clnu.2020.03.009_bib67) 2018; 48 Lucas (10.1016/j.clnu.2020.03.009_bib2) 2011; 171 Burgess (10.1016/j.clnu.2020.03.009_bib28) 2014; 43 Burgess (10.1016/j.clnu.2020.03.009_bib32) 2013; 37 Luo (10.1016/j.clnu.2020.03.009_bib44) 2015; 5 Huffman (10.1016/j.clnu.2020.03.009_bib59) 2015; 10 Nordestgaard (10.1016/j.clnu.2020.03.009_bib48) 2015; 44 Bae (10.1016/j.clnu.2020.03.009_bib1) 2014; 3 Hemani (10.1016/j.clnu.2020.03.009_bib33) 2018; 7 Denny (10.1016/j.clnu.2020.03.009_bib18) 2016; 17 Larsson (10.1016/j.clnu.2020.03.009_bib38) 2018; 77 Giustina (10.1016/j.clnu.2020.03.009_bib45) 2008; 29 Stata Corp (10.1016/j.clnu.2020.03.009_bib29) 1996 Felson (10.1016/j.clnu.2020.03.009_bib42) 2000; 133 Tai (10.1016/j.clnu.2020.03.009_bib4) 2010; 62 Bondemark (10.1016/j.clnu.2020.03.009_bib12) 2015; 37 Hudson (10.1016/j.clnu.2020.03.009_bib56) 2001; 22 Allen (10.1016/j.clnu.2020.03.009_bib69) 2012; 1 UK Biobank (10.1016/j.clnu.2020.03.009_bib24) 2018 Chu (10.1016/j.clnu.2020.03.009_bib8) 2012; 131 Nehlig (10.1016/j.clnu.2020.03.009_bib9) 2015; 16 Lee (10.1016/j.clnu.2020.03.009_bib41) 2018; 37 Pasman (10.1016/j.clnu.2020.03.009_bib51) 1997; 21 Dal Piaz (10.1016/j.clnu.2020.03.009_bib3) 2013; 82 Greay (10.1016/j.clnu.2020.03.009_bib5) 2015; 14 Zhou (10.1016/j.clnu.2020.03.009_bib23) 2019; 109 Tan (10.1016/j.clnu.2020.03.009_bib43) 2018; 295 Emdin (10.1016/j.clnu.2020.03.009_bib16) 2017; 19 Benjamini (10.1016/j.clnu.2020.03.009_bib30) 1995; 57 Bowden (10.1016/j.clnu.2020.03.009_bib35) 2016; 40 Verma (10.1016/j.clnu.2020.03.009_bib27) 2018; 19 Lyall (10.1016/j.clnu.2020.03.009_bib22) 2017; 2 Holmes (10.1016/j.clnu.2020.03.009_bib63) 2017; 14 UK Biobank (10.1016/j.clnu.2020.03.009_bib20) 2018 Tan (10.1016/j.clnu.2020.03.009_bib46) 2012; 214 Niseteo (10.1016/j.clnu.2020.03.009_bib7) 2012; 134 Tsuchiya (10.1016/j.clnu.2020.03.009_bib55) 2005; 227 Verbanck (10.1016/j.clnu.2020.03.009_bib37) 2018; 50 Bowden (10.1016/j.clnu.2020.03.009_bib34) 2015; 44 Davey Smith (10.1016/j.clnu.2020.03.009_bib13) 2003; 32 Haworth (10.1016/j.clnu.2020.03.009_bib71) 2019; 10 Sutherland (10.1016/j.clnu.2020.03.009_bib54) 2017; 607 Westerterp-Plantenga (10.1016/j.clnu.2020.03.009_bib52) 2005; 13 Sekula (10.1016/j.clnu.2020.03.009_bib15) 2016; 27 Dulloo (10.1016/j.clnu.2020.03.009_bib50) 1989; 49 Poole (10.1016/j.clnu.2020.03.009_bib10) 2017; 359 Diepvens (10.1016/j.clnu.2020.03.009_bib53) 2007; 292 Hemani (10.1016/j.clnu.2020.03.009_bib31) 2018; 27 Gupta (10.1016/j.clnu.2020.03.009_bib14) 2017; 145 Manolio (10.1016/j.clnu.2020.03.009_bib70) 2010; 304 Fry (10.1016/j.clnu.2020.03.009_bib66) 2017; 186 Hartwig (10.1016/j.clnu.2020.03.009_bib36) 2017; 46 Kottgen (10.1016/j.clnu.2020.03.009_bib58) 2013; 45 |
| References_xml | – volume: 22 start-page: 426 year: 2011 end-page: 440 ident: bib6 article-title: Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression publication-title: J Nutr Biochem – year: 2018 ident: bib24 article-title: Category 100091: health-related outcomes – volume: 51 start-page: 759 year: 1990 end-page: 767 ident: bib49 article-title: Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers publication-title: Am J Clin Nutr – volume: 19 start-page: 1925 year: 2017 end-page: 1926 ident: bib16 article-title: Mendelian randomization publication-title: JAMA – volume: 77 start-page: 1544 year: 2018 end-page: 1546 ident: bib38 article-title: Coffee consumption and gout: a Mendelian randomisation study publication-title: Ann Rheum Dis – volume: 27 start-page: 3253 year: 2016 end-page: 3265 ident: bib15 article-title: Mendelian randomization as an approach to assess causality using observational data publication-title: J Am Soc Nephrol – volume: 44 start-page: 512 year: 2015 end-page: 525 ident: bib34 article-title: Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression publication-title: Int J Epidemiol – volume: 607 start-page: 36 year: 2017 end-page: 40 ident: bib54 article-title: Investigation of polymorphisms in genes involved in estrogen metabolism in menstrual migraine publication-title: Gene – volume: 17 start-page: 353 year: 2016 end-page: 373 ident: bib18 article-title: Phenome-wide association studies as a tool to advance precision medicine publication-title: Annu Rev Genom Hum Genet – volume: 5 year: 2015 ident: bib44 article-title: Prenatal caffeine exposure induces a poor quality of articular cartilage in male adult offspring rats via cholesterol accumulation in cartilage publication-title: Europe PMC – volume: 40 start-page: 304 year: 2016 end-page: 314 ident: bib35 article-title: Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator publication-title: Genet Epidemiol – volume: 10 year: 2018 ident: bib62 article-title: Mendelian randomization studies of coffee and caffeine consumption publication-title: Nutrients – volume: 7 year: 2018 ident: bib33 article-title: The MR-Base platform supports systematic causal inference across the human phenome publication-title: eLife – volume: 15 start-page: 97 year: 1996 end-page: 101 ident: bib40 article-title: Reasons for changing caffeinated coffee consumption: the Rancho Bernardo Study publication-title: J Am Coll Nutr – volume: 362 start-page: k601 year: 2018 ident: bib61 article-title: Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians publication-title: BMJ – volume: 57 start-page: 289 year: 1995 end-page: 300 ident: bib30 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J Roy Stat Soc – volume: 19 start-page: 120 year: 2018 ident: bib27 article-title: A simulation study investigating power estimates in phenome-wide association studies publication-title: BMC Bioinf – volume: 359 start-page: j5375 year: 2017 ident: bib60 article-title: Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis publication-title: BMJ – volume: 2 start-page: 882 year: 2017 end-page: 889 ident: bib22 article-title: Association of body mass index with cardiometabolic disease in the UK Biobank: a Mendelian randomization study publication-title: JAMA Cardiol – volume: 49 start-page: 44 year: 1989 end-page: 50 ident: bib50 article-title: Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers publication-title: Am J Clin Nutr – volume: 145 start-page: 113 year: 2017 end-page: 119 ident: bib14 article-title: ‘Mendelian randomization’: an approach for exploring causal relations in epidemiology publication-title: Publ Health – volume: 43 start-page: 922 year: 2014 end-page: 929 ident: bib28 article-title: Sample size and power calculations in Mendelian randomization with a single instrumental variable and a binary outcome publication-title: Int J Epidemiol – volume: 82 start-page: 14 year: 2013 end-page: 26 ident: bib3 article-title: Chemical proteomics reveals HSP70 1A as a target for the anticancer diterpene oridonin in Jurkat cells publication-title: J Proteomics – volume: 50 start-page: 693 year: 2018 ident: bib37 article-title: Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases publication-title: Nat Genet – volume: 10 start-page: 333 year: 2019 ident: bib71 article-title: Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis publication-title: Nat Commun – volume: 227 start-page: 115 year: 2005 end-page: 124 ident: bib55 article-title: Cytochrome P450-mediated metabolism of estrogens and its regulation in human publication-title: Cancer Lett – volume: 45 start-page: 145 year: 2013 end-page: 154 ident: bib58 article-title: Genome-wide association analyses identify 18 new loci associated with serum urate concentrations publication-title: Nat Genet – volume: 62 start-page: 1044 year: 2010 end-page: 1057 ident: bib4 article-title: Antiproliferation effect of commercially brewed coffees on human ovarian cancer cells in vitro publication-title: Nutr Cancer – volume: 131 start-page: 564 year: 2012 end-page: 568 ident: bib8 article-title: Bioactivities of crude caffeine: antioxidant activity, cyclooxygenase-2 inhibition, and enhanced glucose uptake publication-title: Food Chem – volume: 27 start-page: R195 year: 2018 end-page: R208 ident: bib31 article-title: Evaluating the potential role of pleiotropy in Mendelian randomization studies publication-title: Hum Mol Genet – year: 2017 ident: bib57 article-title: GWAS Catalog of published genome-wide association studies – volume: 109 start-page: 509 year: 2019 end-page: 516 ident: bib64 article-title: Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis up to 347,077 individuals and 8,368 cases publication-title: Am J Clin Nutr – volume: 15 start-page: 97 year: 2017 ident: bib47 article-title: Habitual coffee consumption and genetic predisposition to obesity: gene-diet interaction analyses in three US prospective studies publication-title: BMC Med – volume: 46 start-page: 1985 year: 2017 end-page: 1998 ident: bib36 article-title: Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption publication-title: Int J Epidemiol – volume: 109 start-page: 509 year: 2019 end-page: 516 ident: bib23 article-title: Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis of up to 347,077 individuals and 8368 cases publication-title: Am J Clin Nutr – volume: 17 start-page: 129 year: 2016 end-page: 145 ident: bib17 article-title: Unravelling the human genome-phenome relationship using phenome-wide association studies publication-title: Nat Rev Genet – volume: 37 start-page: 658 year: 2013 end-page: 665 ident: bib32 article-title: Mendelian randomization analysis with multiple genetic variants using summarized data publication-title: Genet Epidemiol – volume: 48 start-page: 691 year: 2018 end-page: 701 ident: bib67 article-title: Contextualizing selection bias in Mendelian randomization: how bad is it likely to be? publication-title: Int J Epidemiol – volume: 37 start-page: 3133 year: 2018 end-page: 3139 ident: bib41 article-title: Investigating the possible causal association of coffee consumption with osteoarthritis risk using a Mendelian randomization analysis publication-title: Clin Rheumatol – volume: 44 start-page: 551 year: 2015 end-page: 565 ident: bib48 article-title: Coffee intake and risk of obesity, metabolic syndrome and type 2 diabetes: a Mendelian randomization study publication-title: Int J Epidemiol – volume: 14 start-page: 1 year: 2015 end-page: 6 ident: bib5 article-title: Recent developments in the bioactivity of mono- and diterpenes: anticancer and antimicrobial activity publication-title: Phytochemistry Rev – volume: 12 year: 2017 ident: bib26 article-title: Evaluating phecodes, clinical classification software, and ICD-9-CM codes for phenome-wide association studies in the electronic health record publication-title: PloS One – volume: 31 start-page: 1102 year: 2013 end-page: 1110 ident: bib25 article-title: Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data publication-title: Nat Biotechnol – volume: 295 start-page: 229 year: 2018 end-page: 236 ident: bib43 article-title: Prenatal caffeine exprosure increases adult female offspring rat's susceptibility to osteoarthritis via low-functional programming of cartilage IGF-1 with histone acetylation publication-title: Toxicol Lett – volume: 10 year: 2015 ident: bib59 article-title: Modulation of genetic associations with serum urate levels by body-mass-index in humans publication-title: PloS One – volume: 16 start-page: 89 year: 2015 end-page: 95 ident: bib9 article-title: Effects of coffee/caffeine on brain health and disease: what should I tell my patients? publication-title: Practical Neurol – volume: 14 start-page: 577 year: 2017 end-page: 590 ident: bib63 article-title: Mendelian randomization in cardiometabolic disease: challenges in evaluating causality publication-title: Nat Rev Cardiol – volume: 22 start-page: 763 year: 2001 end-page: 770 ident: bib56 article-title: Steroid hormones modulate expression of cytochrome P450 enzymes in male hamster reproductive tract and leiomyosarcomas publication-title: Carcinogenesis – volume: 359 start-page: 1 year: 2017 end-page: 18 ident: bib10 article-title: Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes publication-title: BMJ – volume: 186 start-page: 1026 year: 2017 end-page: 1034 ident: bib66 article-title: Comparison of sociodemographic and health-related characteristics of UK Biobank participants with those of the general population publication-title: Am J Epidemiol – year: 2007 ident: bib21 article-title: Ethics and governance framework – volume: 20 start-page: 135 year: 2018 ident: bib39 article-title: Mediation analysis to understand genetic relationships between habitual coffee intake and gout publication-title: Arthritis Res Ther – volume: 171 start-page: 1571 year: 2011 end-page: 1578 ident: bib2 article-title: Coffee, caffeine, and risk of depression among women publication-title: Arch Intern Med – volume: 134 start-page: 1870 year: 2012 end-page: 1877 ident: bib7 article-title: Bioactive composition and antioxidant potential of different commonly consumed coffee brews affected by their preparation technique and milk addition publication-title: Food Chem – volume: 292 start-page: R77 year: 2007 end-page: R85 ident: bib53 article-title: Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea publication-title: Am J Physiol Regul Integr Comp Physiol – volume: 304 start-page: 2290 year: 2010 end-page: 2291 ident: bib70 article-title: Enhancing the feasibility of large cohort studies publication-title: JAMA – volume: 37 start-page: 457 year: 2015 end-page: 461 ident: bib12 article-title: Randomized controlled trial: the gold standard or an unobtainable fallacy? publication-title: Eur J Orthod – volume: 21 start-page: 1143 year: 1997 end-page: 1151 ident: bib51 article-title: The effectiveness of long-term supplementation of carbohydrate, chromium, fibre and caffeine on weight maintenance publication-title: Int J Obes Relat Metab Disord – volume: 379 start-page: 1173 year: 2012 end-page: 1174 ident: bib68 article-title: What makes UK Biobank special? publication-title: Lancet – volume: 13 start-page: 1195 year: 2005 end-page: 1204 ident: bib52 article-title: Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation publication-title: Obes Res – volume: 214 start-page: 279 year: 2012 end-page: 287 ident: bib46 article-title: Caffeine-induced fetal rat over-exposure to maternal glucocorticoid and histone methylation of liver IGF-1 might cause skeletal growth retardation publication-title: Toxicol Lett – volume: 3 start-page: 189 year: 2014 end-page: 191 ident: bib1 article-title: Coffee and health publication-title: Integr Med Res – volume: 1 start-page: 123 year: 2012 end-page: 126 ident: bib69 article-title: UK Biobank: current status and what it means for epidemiology publication-title: Health Pol Technol – volume: 29 start-page: 535 year: 2008 end-page: 559 ident: bib45 article-title: Growth hormone, insulin-like growth factors, and the skeleton publication-title: Endocr Rev – volume: 37 start-page: 131 year: 2017 end-page: 156 ident: bib11 article-title: Coffee, caffeine, and health outcomes: an umbrella review publication-title: Annu Rev Nutr – volume: 133 start-page: 635 year: 2000 end-page: 646 ident: bib42 article-title: Osteoarthritis: new insights. Part 1: the disease and its risk factors publication-title: Ann Intern Med – volume: 20 start-page: 647 year: 2015 end-page: 656 ident: bib19 article-title: Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption publication-title: Mol Psychiatry – year: 1996 ident: bib29 article-title: Stata – year: 2018 ident: bib20 article-title: About UK Biobank – volume: 106 start-page: 67 year: 2018 end-page: 73 ident: bib65 article-title: The influence of CYP1A2 genotype in the blood pressure response to caffeine ingestion is affected by physical activity status and caffeine consumption level publication-title: Vasc Pharmacol – volume: 32 start-page: 1 year: 2003 end-page: 22 ident: bib13 article-title: 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? publication-title: Int J Epidemiol – volume: 22 start-page: 426 issue: 5 year: 2011 ident: 10.1016/j.clnu.2020.03.009_bib6 article-title: Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression publication-title: J Nutr Biochem doi: 10.1016/j.jnutbio.2010.03.011 – year: 2018 ident: 10.1016/j.clnu.2020.03.009_bib24 – volume: 31 start-page: 1102 issue: 12 year: 2013 ident: 10.1016/j.clnu.2020.03.009_bib25 article-title: Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data publication-title: Nat Biotechnol doi: 10.1038/nbt.2749 – volume: 37 start-page: 658 issue: 7 year: 2013 ident: 10.1016/j.clnu.2020.03.009_bib32 article-title: Mendelian randomization analysis with multiple genetic variants using summarized data publication-title: Genet Epidemiol doi: 10.1002/gepi.21758 – volume: 37 start-page: 457 issue: 5 year: 2015 ident: 10.1016/j.clnu.2020.03.009_bib12 article-title: Randomized controlled trial: the gold standard or an unobtainable fallacy? publication-title: Eur J Orthod doi: 10.1093/ejo/cjv046 – volume: 21 start-page: 1143 issue: 12 year: 1997 ident: 10.1016/j.clnu.2020.03.009_bib51 article-title: The effectiveness of long-term supplementation of carbohydrate, chromium, fibre and caffeine on weight maintenance publication-title: Int J Obes Relat Metab Disord doi: 10.1038/sj.ijo.0800528 – volume: 17 start-page: 129 issue: 3 year: 2016 ident: 10.1016/j.clnu.2020.03.009_bib17 article-title: Unravelling the human genome-phenome relationship using phenome-wide association studies publication-title: Nat Rev Genet doi: 10.1038/nrg.2015.36 – volume: 45 start-page: 145 issue: 2 year: 2013 ident: 10.1016/j.clnu.2020.03.009_bib58 article-title: Genome-wide association analyses identify 18 new loci associated with serum urate concentrations publication-title: Nat Genet doi: 10.1038/ng.2500 – volume: 22 start-page: 763 issue: 5 year: 2001 ident: 10.1016/j.clnu.2020.03.009_bib56 article-title: Steroid hormones modulate expression of cytochrome P450 enzymes in male hamster reproductive tract and leiomyosarcomas publication-title: Carcinogenesis doi: 10.1093/carcin/22.5.763 – volume: 16 start-page: 89 year: 2015 ident: 10.1016/j.clnu.2020.03.009_bib9 article-title: Effects of coffee/caffeine on brain health and disease: what should I tell my patients? publication-title: Practical Neurol doi: 10.1136/practneurol-2015-001162 – volume: 295 start-page: 229 year: 2018 ident: 10.1016/j.clnu.2020.03.009_bib43 article-title: Prenatal caffeine exprosure increases adult female offspring rat's susceptibility to osteoarthritis via low-functional programming of cartilage IGF-1 with histone acetylation publication-title: Toxicol Lett doi: 10.1016/j.toxlet.2018.06.1221 – volume: 5 issue: 17746 year: 2015 ident: 10.1016/j.clnu.2020.03.009_bib44 article-title: Prenatal caffeine exposure induces a poor quality of articular cartilage in male adult offspring rats via cholesterol accumulation in cartilage publication-title: Europe PMC – volume: 44 start-page: 512 issue: 2 year: 2015 ident: 10.1016/j.clnu.2020.03.009_bib34 article-title: Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression publication-title: Int J Epidemiol doi: 10.1093/ije/dyv080 – volume: 10 issue: 3 year: 2015 ident: 10.1016/j.clnu.2020.03.009_bib59 article-title: Modulation of genetic associations with serum urate levels by body-mass-index in humans publication-title: PloS One doi: 10.1371/journal.pone.0119752 – volume: 10 start-page: 333 issue: 1 year: 2019 ident: 10.1016/j.clnu.2020.03.009_bib71 article-title: Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis publication-title: Nat Commun doi: 10.1038/s41467-018-08219-1 – volume: 37 start-page: 3133 issue: 11 year: 2018 ident: 10.1016/j.clnu.2020.03.009_bib41 article-title: Investigating the possible causal association of coffee consumption with osteoarthritis risk using a Mendelian randomization analysis publication-title: Clin Rheumatol doi: 10.1007/s10067-018-4252-6 – volume: 133 start-page: 635 issue: 8 year: 2000 ident: 10.1016/j.clnu.2020.03.009_bib42 article-title: Osteoarthritis: new insights. Part 1: the disease and its risk factors publication-title: Ann Intern Med doi: 10.7326/0003-4819-133-8-200010170-00016 – volume: 48 start-page: 691 issue: 3 year: 2018 ident: 10.1016/j.clnu.2020.03.009_bib67 article-title: Contextualizing selection bias in Mendelian randomization: how bad is it likely to be? publication-title: Int J Epidemiol doi: 10.1093/ije/dyy202 – volume: 17 start-page: 353 year: 2016 ident: 10.1016/j.clnu.2020.03.009_bib18 article-title: Phenome-wide association studies as a tool to advance precision medicine publication-title: Annu Rev Genom Hum Genet doi: 10.1146/annurev-genom-090314-024956 – volume: 14 start-page: 577 issue: 10 year: 2017 ident: 10.1016/j.clnu.2020.03.009_bib63 article-title: Mendelian randomization in cardiometabolic disease: challenges in evaluating causality publication-title: Nat Rev Cardiol doi: 10.1038/nrcardio.2017.78 – volume: 82 start-page: 14 year: 2013 ident: 10.1016/j.clnu.2020.03.009_bib3 article-title: Chemical proteomics reveals HSP70 1A as a target for the anticancer diterpene oridonin in Jurkat cells publication-title: J Proteomics doi: 10.1016/j.jprot.2013.01.030 – volume: 10 issue: 10 year: 2018 ident: 10.1016/j.clnu.2020.03.009_bib62 article-title: Mendelian randomization studies of coffee and caffeine consumption publication-title: Nutrients doi: 10.3390/nu10101343 – volume: 27 start-page: 3253 issue: 11 year: 2016 ident: 10.1016/j.clnu.2020.03.009_bib15 article-title: Mendelian randomization as an approach to assess causality using observational data publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2016010098 – volume: 359 start-page: 1 year: 2017 ident: 10.1016/j.clnu.2020.03.009_bib10 article-title: Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes publication-title: BMJ – volume: 3 start-page: 189 issue: 4 year: 2014 ident: 10.1016/j.clnu.2020.03.009_bib1 article-title: Coffee and health publication-title: Integr Med Res doi: 10.1016/j.imr.2014.08.002 – volume: 19 start-page: 120 issue: 1 year: 2018 ident: 10.1016/j.clnu.2020.03.009_bib27 article-title: A simulation study investigating power estimates in phenome-wide association studies publication-title: BMC Bioinf doi: 10.1186/s12859-018-2135-0 – volume: 15 start-page: 97 issue: 1 year: 1996 ident: 10.1016/j.clnu.2020.03.009_bib40 article-title: Reasons for changing caffeinated coffee consumption: the Rancho Bernardo Study publication-title: J Am Coll Nutr doi: 10.1080/07315724.1996.10718571 – volume: 171 start-page: 1571 issue: 17 year: 2011 ident: 10.1016/j.clnu.2020.03.009_bib2 article-title: Coffee, caffeine, and risk of depression among women publication-title: Arch Intern Med doi: 10.1001/archinternmed.2011.393 – volume: 29 start-page: 535 issue: 5 year: 2008 ident: 10.1016/j.clnu.2020.03.009_bib45 article-title: Growth hormone, insulin-like growth factors, and the skeleton publication-title: Endocr Rev doi: 10.1210/er.2007-0036 – volume: 379 start-page: 1173 issue: 9822 year: 2012 ident: 10.1016/j.clnu.2020.03.009_bib68 article-title: What makes UK Biobank special? publication-title: Lancet doi: 10.1016/S0140-6736(12)60404-8 – volume: 19 start-page: 1925 issue: 318 year: 2017 ident: 10.1016/j.clnu.2020.03.009_bib16 article-title: Mendelian randomization publication-title: JAMA doi: 10.1001/jama.2017.17219 – volume: 27 start-page: R195 issue: R2 year: 2018 ident: 10.1016/j.clnu.2020.03.009_bib31 article-title: Evaluating the potential role of pleiotropy in Mendelian randomization studies publication-title: Hum Mol Genet doi: 10.1093/hmg/ddy163 – volume: 62 start-page: 1044 issue: 8 year: 2010 ident: 10.1016/j.clnu.2020.03.009_bib4 article-title: Antiproliferation effect of commercially brewed coffees on human ovarian cancer cells in vitro publication-title: Nutr Cancer doi: 10.1080/01635581.2010.492083 – volume: 131 start-page: 564 issue: 2 year: 2012 ident: 10.1016/j.clnu.2020.03.009_bib8 article-title: Bioactivities of crude caffeine: antioxidant activity, cyclooxygenase-2 inhibition, and enhanced glucose uptake publication-title: Food Chem doi: 10.1016/j.foodchem.2011.09.024 – year: 2017 ident: 10.1016/j.clnu.2020.03.009_bib57 – volume: 227 start-page: 115 issue: 2 year: 2005 ident: 10.1016/j.clnu.2020.03.009_bib55 article-title: Cytochrome P450-mediated metabolism of estrogens and its regulation in human publication-title: Cancer Lett doi: 10.1016/j.canlet.2004.10.007 – volume: 109 start-page: 509 issue: 3 year: 2019 ident: 10.1016/j.clnu.2020.03.009_bib64 article-title: Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis up to 347,077 individuals and 8,368 cases publication-title: Am J Clin Nutr doi: 10.1093/ajcn/nqy297 – volume: 359 start-page: j5375 year: 2017 ident: 10.1016/j.clnu.2020.03.009_bib60 article-title: Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis publication-title: BMJ doi: 10.1136/bmj.j5375 – volume: 2 start-page: 882 issue: 8 year: 2017 ident: 10.1016/j.clnu.2020.03.009_bib22 article-title: Association of body mass index with cardiometabolic disease in the UK Biobank: a Mendelian randomization study publication-title: JAMA Cardiol doi: 10.1001/jamacardio.2016.5804 – year: 2018 ident: 10.1016/j.clnu.2020.03.009_bib20 – volume: 57 start-page: 289 issue: 1 year: 1995 ident: 10.1016/j.clnu.2020.03.009_bib30 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J Roy Stat Soc doi: 10.1111/j.2517-6161.1995.tb02031.x – volume: 134 start-page: 1870 issue: 4 year: 2012 ident: 10.1016/j.clnu.2020.03.009_bib7 article-title: Bioactive composition and antioxidant potential of different commonly consumed coffee brews affected by their preparation technique and milk addition publication-title: Food Chem doi: 10.1016/j.foodchem.2012.03.095 – volume: 145 start-page: 113 year: 2017 ident: 10.1016/j.clnu.2020.03.009_bib14 article-title: ‘Mendelian randomization’: an approach for exploring causal relations in epidemiology publication-title: Publ Health doi: 10.1016/j.puhe.2016.12.033 – volume: 12 issue: 7 year: 2017 ident: 10.1016/j.clnu.2020.03.009_bib26 article-title: Evaluating phecodes, clinical classification software, and ICD-9-CM codes for phenome-wide association studies in the electronic health record publication-title: PloS One doi: 10.1371/journal.pone.0175508 – volume: 292 start-page: R77 issue: 1 year: 2007 ident: 10.1016/j.clnu.2020.03.009_bib53 article-title: Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.00832.2005 – volume: 20 start-page: 647 issue: 5 year: 2015 ident: 10.1016/j.clnu.2020.03.009_bib19 article-title: Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption publication-title: Mol Psychiatry doi: 10.1038/mp.2014.107 – volume: 32 start-page: 1 issue: 1 year: 2003 ident: 10.1016/j.clnu.2020.03.009_bib13 article-title: 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? publication-title: Int J Epidemiol doi: 10.1093/ije/dyg070 – volume: 15 start-page: 97 issue: 1 year: 2017 ident: 10.1016/j.clnu.2020.03.009_bib47 article-title: Habitual coffee consumption and genetic predisposition to obesity: gene-diet interaction analyses in three US prospective studies publication-title: BMC Med doi: 10.1186/s12916-017-0862-0 – volume: 37 start-page: 131 issue: 1 year: 2017 ident: 10.1016/j.clnu.2020.03.009_bib11 article-title: Coffee, caffeine, and health outcomes: an umbrella review publication-title: Annu Rev Nutr doi: 10.1146/annurev-nutr-071816-064941 – volume: 44 start-page: 551 issue: 2 year: 2015 ident: 10.1016/j.clnu.2020.03.009_bib48 article-title: Coffee intake and risk of obesity, metabolic syndrome and type 2 diabetes: a Mendelian randomization study publication-title: Int J Epidemiol doi: 10.1093/ije/dyv083 – volume: 50 start-page: 693 issue: 5 year: 2018 ident: 10.1016/j.clnu.2020.03.009_bib37 article-title: Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases publication-title: Nat Genet doi: 10.1038/s41588-018-0099-7 – volume: 106 start-page: 67 year: 2018 ident: 10.1016/j.clnu.2020.03.009_bib65 article-title: The influence of CYP1A2 genotype in the blood pressure response to caffeine ingestion is affected by physical activity status and caffeine consumption level publication-title: Vasc Pharmacol doi: 10.1016/j.vph.2018.03.002 – volume: 13 start-page: 1195 issue: 7 year: 2005 ident: 10.1016/j.clnu.2020.03.009_bib52 article-title: Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation publication-title: Obes Res doi: 10.1038/oby.2005.142 – volume: 43 start-page: 922 issue: 3 year: 2014 ident: 10.1016/j.clnu.2020.03.009_bib28 article-title: Sample size and power calculations in Mendelian randomization with a single instrumental variable and a binary outcome publication-title: Int J Epidemiol doi: 10.1093/ije/dyu005 – year: 2007 ident: 10.1016/j.clnu.2020.03.009_bib21 – volume: 109 start-page: 509 issue: 3 year: 2019 ident: 10.1016/j.clnu.2020.03.009_bib23 article-title: Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis of up to 347,077 individuals and 8368 cases publication-title: Am J Clin Nutr doi: 10.1093/ajcn/nqy297 – volume: 186 start-page: 1026 issue: 9 year: 2017 ident: 10.1016/j.clnu.2020.03.009_bib66 article-title: Comparison of sociodemographic and health-related characteristics of UK Biobank participants with those of the general population publication-title: Am J Epidemiol doi: 10.1093/aje/kwx246 – volume: 51 start-page: 759 issue: 5 year: 1990 ident: 10.1016/j.clnu.2020.03.009_bib49 article-title: Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers publication-title: Am J Clin Nutr doi: 10.1093/ajcn/51.5.759 – volume: 7 year: 2018 ident: 10.1016/j.clnu.2020.03.009_bib33 article-title: The MR-Base platform supports systematic causal inference across the human phenome publication-title: eLife doi: 10.7554/eLife.34408 – volume: 362 start-page: k601 year: 2018 ident: 10.1016/j.clnu.2020.03.009_bib61 article-title: Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians publication-title: BMJ doi: 10.1136/bmj.k601 – volume: 46 start-page: 1985 issue: 6 year: 2017 ident: 10.1016/j.clnu.2020.03.009_bib36 article-title: Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption publication-title: Int J Epidemiol doi: 10.1093/ije/dyx102 – volume: 20 start-page: 135 issue: 1 year: 2018 ident: 10.1016/j.clnu.2020.03.009_bib39 article-title: Mediation analysis to understand genetic relationships between habitual coffee intake and gout publication-title: Arthritis Res Ther doi: 10.1186/s13075-018-1629-5 – volume: 607 start-page: 36 year: 2017 ident: 10.1016/j.clnu.2020.03.009_bib54 article-title: Investigation of polymorphisms in genes involved in estrogen metabolism in menstrual migraine publication-title: Gene doi: 10.1016/j.gene.2017.01.008 – volume: 77 start-page: 1544 issue: 10 year: 2018 ident: 10.1016/j.clnu.2020.03.009_bib38 article-title: Coffee consumption and gout: a Mendelian randomisation study publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2018-213055 – volume: 304 start-page: 2290 issue: 20 year: 2010 ident: 10.1016/j.clnu.2020.03.009_bib70 article-title: Enhancing the feasibility of large cohort studies publication-title: JAMA doi: 10.1001/jama.2010.1686 – volume: 214 start-page: 279 issue: 3 year: 2012 ident: 10.1016/j.clnu.2020.03.009_bib46 article-title: Caffeine-induced fetal rat over-exposure to maternal glucocorticoid and histone methylation of liver IGF-1 might cause skeletal growth retardation publication-title: Toxicol Lett doi: 10.1016/j.toxlet.2012.09.007 – volume: 14 start-page: 1 issue: 1 year: 2015 ident: 10.1016/j.clnu.2020.03.009_bib5 article-title: Recent developments in the bioactivity of mono- and diterpenes: anticancer and antimicrobial activity publication-title: Phytochemistry Rev doi: 10.1007/s11101-011-9212-6 – volume: 1 start-page: 123 issue: 3 year: 2012 ident: 10.1016/j.clnu.2020.03.009_bib69 article-title: UK Biobank: current status and what it means for epidemiology publication-title: Health Pol Technol doi: 10.1016/j.hlpt.2012.07.003 – year: 1996 ident: 10.1016/j.clnu.2020.03.009_bib29 – volume: 49 start-page: 44 issue: 1 year: 1989 ident: 10.1016/j.clnu.2020.03.009_bib50 article-title: Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers publication-title: Am J Clin Nutr doi: 10.1093/ajcn/49.1.44 – volume: 40 start-page: 304 issue: 4 year: 2016 ident: 10.1016/j.clnu.2020.03.009_bib35 article-title: Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator publication-title: Genet Epidemiol doi: 10.1002/gepi.21965 |
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| Title | Association between habitual coffee consumption and multiple disease outcomes: A Mendelian randomisation phenome-wide association study in the UK Biobank |
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