Preparation and characterization of polycaprolactone-polyethylene glycol methyl ether and polycaprolactone-chitosan electrospun mats potential for vascular tissue engineering
Recently, natural polymers are frequently comingled with synthetic polymers either by physical or chemical modification to prepare numerous tissue-engineered graft with promising biological function, strength, and stability. The aim of this study was to determine the efficiency for vascular tissue e...
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Published in | Journal of biomaterials applications Vol. 32; no. 5; p. 648 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.11.2017
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Abstract | Recently, natural polymers are frequently comingled with synthetic polymers either by physical or chemical modification to prepare numerous tissue-engineered graft with promising biological function, strength, and stability. The aim of this study was to determine the efficiency for vascular tissue engineering of two distinctly different mats, one that comprised polycaprolactone-polyethylene glycol methyl ether and other that comprised polycaprolactone-chitosan. Nano/microfibrous mats prepared from electro-spinning were characterized for fiber diameter, porosity, wettability, and mechanical strength. Biological efficacy on both biodegradable mats was assessed by rat bone marrow mesenchymal stem cells, and polycaprolactone-polyethylene glycol methyl ether showed feasibility for use as an inner layer by inducing endothelial-specific gene expression and polycaprolactone-chitosan as an outer layer on dual layered without sacrificing tensile strength, small-diameter blood vessels. Therefore, scaffolds fabricated from this research could be potential sources for tissue-engineered vascular graft and could also overcome the well-known drawbacks, such as thrombogenicity and stenosis, in managing vascular disease. |
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AbstractList | Recently, natural polymers are frequently comingled with synthetic polymers either by physical or chemical modification to prepare numerous tissue-engineered graft with promising biological function, strength, and stability. The aim of this study was to determine the efficiency for vascular tissue engineering of two distinctly different mats, one that comprised polycaprolactone-polyethylene glycol methyl ether and other that comprised polycaprolactone-chitosan. Nano/microfibrous mats prepared from electro-spinning were characterized for fiber diameter, porosity, wettability, and mechanical strength. Biological efficacy on both biodegradable mats was assessed by rat bone marrow mesenchymal stem cells, and polycaprolactone-polyethylene glycol methyl ether showed feasibility for use as an inner layer by inducing endothelial-specific gene expression and polycaprolactone-chitosan as an outer layer on dual layered without sacrificing tensile strength, small-diameter blood vessels. Therefore, scaffolds fabricated from this research could be potential sources for tissue-engineered vascular graft and could also overcome the well-known drawbacks, such as thrombogenicity and stenosis, in managing vascular disease. |
Author | Sultana, Tamanna Amirian, Jhaleh Park, Chanmi Lee, Seung Jin Lee, Byong-Taek |
Author_xml | – sequence: 1 givenname: Tamanna surname: Sultana fullname: Sultana, Tamanna organization: 1 Department of Regenerative Medicine, College of Medicine, Soonchunhyang University 366-1, Ssangyoung-Dong, Cheonan City, ChungCheonNam-Do, Republic of Korea – sequence: 2 givenname: Jhaleh orcidid: 0000-0002-5030-901X surname: Amirian fullname: Amirian, Jhaleh organization: 2 Institute of Tissue Regeneration, Soonchunhyang University 366-1, Ssangyoung-Dong, Cheonan City, ChungCheonNam-Do, Republic of Korea – sequence: 3 givenname: Chanmi surname: Park fullname: Park, Chanmi organization: 2 Institute of Tissue Regeneration, Soonchunhyang University 366-1, Ssangyoung-Dong, Cheonan City, ChungCheonNam-Do, Republic of Korea – sequence: 4 givenname: Seung Jin surname: Lee fullname: Lee, Seung Jin organization: 3 Department of Thoracic and Cardiovascular Surgery, Soonchunhyang University Hospital, 31, 6-gil, Cheonan City, ChungCheonNam-Do, Republic of Korea – sequence: 5 givenname: Byong-Taek orcidid: 0000-0002-3613-7610 surname: Lee fullname: Lee, Byong-Taek organization: 2 Institute of Tissue Regeneration, Soonchunhyang University 366-1, Ssangyoung-Dong, Cheonan City, ChungCheonNam-Do, Republic of Korea |
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Keywords | polyethylene glycol methyl ether chitosan vascular grafts Electro-spinning polycaprolactone surface modification |
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SubjectTerms | Animals Biocompatible Materials - chemistry Blood Vessel Prosthesis Cells, Cultured Chitosan - analogs & derivatives Materials Testing Mesenchymal Stromal Cells - cytology Methyl Ethers - chemistry Polyesters - chemistry Polyethylene Glycols - chemistry Porosity Rats Tensile Strength Tissue Engineering - methods Tissue Scaffolds - chemistry |
Title | Preparation and characterization of polycaprolactone-polyethylene glycol methyl ether and polycaprolactone-chitosan electrospun mats potential for vascular tissue engineering |
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