Endothelial function and dysfunction: Impact of metformin

Cardiovascular and metabolic diseases remain the leading cause of morbidity and mortality worldwide. Endothelial dysfunction is a key player in the initiation and progression of cardiovascular and metabolic diseases. Current evidence suggests that the anti-diabetic drug metformin improves insulin re...

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Published inPharmacology & therapeutics (Oxford) Vol. 192; pp. 150 - 162
Main Authors Nafisa, Asma, Gray, Susan G., Cao, Yingnan, Wang, Tinghuai, Xu, Suowen, Wattoo, Feroza H., Barras, Michael, Cohen, Neale, Kamato, Danielle, Little, Peter J.
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 01.12.2018
Subjects
CVD
Endothelial dysfunction
Endothelium
Hyperglycaemia
Mechanism of action
Metformin
eNOS
TNFα
TRAF3IP2
NF-kB
mPTP
ICAM1
Endothelial dysfunction
mTOR
PAI-1
AngII
ED
VSMCs
PEPCK
PAPP1
G6PDH
H2S
AJ
PKC
DHAP
MAPK
ER
Endothelium
BH4
PPARδ
CVD
PCOS
EDRF
ET-1
NOX
ROS
Sirt1
Metformin
GAPDH
NO
Hyperglycaemia
PGC1α
vWF
cGMP
LOX-1
MCP1
Mn-SOD
Mechanism of action
HUVECS
AGE
t-PA
HSP90
VCAM1
GCH1
GTPCH1
PGI2
FMN
VEGF
FAD
Bcl6
TJ
u-PA
EDHF
Online AccessGet full text

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Abstract Cardiovascular and metabolic diseases remain the leading cause of morbidity and mortality worldwide. Endothelial dysfunction is a key player in the initiation and progression of cardiovascular and metabolic diseases. Current evidence suggests that the anti-diabetic drug metformin improves insulin resistance and protects against endothelial dysfunction in the vasculature. Hereby, we provide a timely review on the protective effects and molecular mechanisms of metformin in preventing endothelial dysfunction and cardiovascular and metabolic diseases.
AbstractList Cardiovascular and metabolic diseases remain the leading cause of morbidity and mortality worldwide. Endothelial dysfunction is a key player in the initiation and progression of cardiovascular and metabolic diseases. Current evidence suggests that the anti-diabetic drug metformin improves insulin resistance and protects against endothelial dysfunction in the vasculature. Hereby, we provide a timely review on the protective effects and molecular mechanisms of metformin in preventing endothelial dysfunction and cardiovascular and metabolic diseases.
Cardiovascular and metabolic diseases remain the leading cause of morbidity and mortality worldwide. Endothelial dysfunction is a key player in the initiation and progression of cardiovascular and metabolic diseases. Current evidence suggests that the anti-diabetic drug metformin improves insulin resistance and protects against endothelial dysfunction in the vasculature. Hereby, we provide a timely review on the protective effects and molecular mechanisms of metformin in preventing endothelial dysfunction and cardiovascular and metabolic diseases.Cardiovascular and metabolic diseases remain the leading cause of morbidity and mortality worldwide. Endothelial dysfunction is a key player in the initiation and progression of cardiovascular and metabolic diseases. Current evidence suggests that the anti-diabetic drug metformin improves insulin resistance and protects against endothelial dysfunction in the vasculature. Hereby, we provide a timely review on the protective effects and molecular mechanisms of metformin in preventing endothelial dysfunction and cardiovascular and metabolic diseases.
Author Kamato, Danielle
Cao, Yingnan
Gray, Susan G.
Xu, Suowen
Wang, Tinghuai
Nafisa, Asma
Wattoo, Feroza H.
Barras, Michael
Cohen, Neale
Little, Peter J.
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  surname: Nafisa
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– sequence: 2
  givenname: Susan G.
  surname: Gray
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  surname: Cao
  fullname: Cao, Yingnan
  organization: Xinhua College of Sun Yat-sen University, Tianhe District, Guangzhou, China
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  givenname: Tinghuai
  surname: Wang
  fullname: Wang, Tinghuai
  email: wangth@mail.sysu.edu.cn
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  givenname: Feroza H.
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  fullname: Wattoo, Feroza H.
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  organization: Department of Biochemistry, PMAS Arid Agriculture University, Shamasabad, Muree Road, Rawalpindi 4600, Pakistan
– sequence: 7
  givenname: Michael
  surname: Barras
  fullname: Barras, Michael
  email: m.barras@uq.edu.au
  organization: Dept. of Pharmacy, Princess Alexandra Hospital, 199 Ipswich Rd, Woolloongabba, QLD 4102, Australia
– sequence: 8
  givenname: Neale
  surname: Cohen
  fullname: Cohen, Neale
  email: neale.cohen@baker.edu.au
  organization: Baker Heart and Diabetes Institute, Melbourne, 3004, Victoria, Australia
– sequence: 9
  givenname: Danielle
  surname: Kamato
  fullname: Kamato, Danielle
  email: d.kamato@uq.edu.au
  organization: School of Pharmacy, University of Queensland, Pharmacy Australia Centre of Excellence, Woolloongabba, QLD, Australia
– sequence: 10
  givenname: Peter J.
  surname: Little
  fullname: Little, Peter J.
  email: p.little@uq.edu.au
  organization: School of Pharmacy, University of Queensland, Pharmacy Australia Centre of Excellence, Woolloongabba, QLD, Australia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30056057$$D View this record in MEDLINE/PubMed
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ISSN 0163-7258
1879-016X
IngestDate Fri Jul 11 03:18:15 EDT 2025
Thu Apr 03 07:05:21 EDT 2025
Thu Apr 24 23:07:50 EDT 2025
Tue Jul 01 03:07:39 EDT 2025
Fri Feb 23 02:15:38 EST 2024
IsPeerReviewed true
IsScholarly true
Keywords eNOS
TNFα
TRAF3IP2
NF-kB
mPTP
ICAM1
Endothelial dysfunction
mTOR
PAI-1
AngII
ED
VSMCs
PEPCK
PAPP1
G6PDH
H2S
AJ
PKC
DHAP
MAPK
ER
Endothelium
BH4
PPARδ
CVD
PCOS
EDRF
ET-1
NOX
ROS
Sirt1
Metformin
GAPDH
NO
Hyperglycaemia
PGC1α
vWF
cGMP
LOX-1
MCP1
Mn-SOD
Mechanism of action
HUVECS
AGE
t-PA
HSP90
VCAM1
GCH1
GTPCH1
PGI2
FMN
VEGF
FAD
Bcl6
TJ
u-PA
EDHF
Language English
License Copyright © 2018 Elsevier Inc. All rights reserved.
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PMID 30056057
PQID 2079956099
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elsevier_sciencedirect_doi_10_1016_j_pharmthera_2018_07_007
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PublicationDate_xml – month: 12
  year: 2018
  text: December 2018
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PublicationPlace England
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PublicationTitle Pharmacology & therapeutics (Oxford)
PublicationTitleAlternate Pharmacol Ther
PublicationYear 2018
Publisher Elsevier Inc
Publisher_xml – name: Elsevier Inc
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Snippet Cardiovascular and metabolic diseases remain the leading cause of morbidity and mortality worldwide. Endothelial dysfunction is a key player in the initiation...
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SubjectTerms CVD
Endothelial dysfunction
Endothelium
Hyperglycaemia
Mechanism of action
Metformin
Title Endothelial function and dysfunction: Impact of metformin
URI https://dx.doi.org/10.1016/j.pharmthera.2018.07.007
https://www.ncbi.nlm.nih.gov/pubmed/30056057
https://www.proquest.com/docview/2079956099
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