Impact of downstream processing on crystal quality during the precipitation of a pharmaceutical product

• Published in: Powder technology Vol. 208; no. 2; pp. 337 - 342
• Main Authors: Estime, N., Teychené, S., Autret, J.M., Biscans, B.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 25.03.2011; Elsevier
• Subjects: API; Applied sciences; Chemical engineering; Chemical Sciences; Coprecipitation; crystals; differential scanning calorimetry; drugs; Efficiency; Exact sciences and technology; filter cake; filtrates; Fluid Dynamics; ingredients; Life Sciences; Miscellaneous; pharmaceutical industry; Pharmaceutical sciences; Physics; scanning electron microscopy; Solid-solid systems; Wash; washing; API; Efficiency; Wash; Coprecipitation; Differential scanning calorimetry; Scanning electron microscopy; Impurity; Reaction product; Washing; Particle size distribution; Morphology; Pharmaceutical industry; Filter cake

In pharmaceutical industries, active pharmaceutical ingredients (API) are made of crystals whose properties must be controlled because they influence the end-use properties of the drug. Even if crystal quality is mainly determined during the precipitation step, downstream processing also has an infl...